Abstract: Objective To study the health related quality of life (HRQOL) score in seborrheic dermatitis patients,and to study the influencing factors on health related quality of life,at last to analysis the major and minor relationship of the factors. Methods A total of 314 patients with seborrhric dermatitis in our hospital were analyzed form February to August in 2015.The short form 36 questionnaire (SF-36) scale was used to assess the HRQOL.The general conditions of seborrheic dermatitis patients were counted.The one-way ANOVA and stepwise regression analysis were used to study the influence factors of HRQOL. Results The average score of SDS was 51.45±9.42.About 56.1% of respondents were no depression.The mild depression accounted for 33.1%,moderate depression for 7%,and severe depression for 3.8%.The difference of HRQOL scores between different seborrheic dermatitis course,age and sleep time had statistical significance (P<0.05).The spicy food,drinking,smoking,doing exercise,treatment Results leaded to the differences of the HRQOL scores (P<0.05).The HRQOL scores of the seborrheic dermatitis patients with long duration,older age and lack of sleep were lower.Spicy food,drinking and smoking reduced the HRQOL scores.Exercise and treatment could improve the HRQOL scores.Stepwise regression analysis showed that:treatment,SDS scores,spicy diet,course of seborrheic dermatitis,physical exercise,drink wine and sleep time were the main influencing factors.HRQOL score was positively correlated with treatment,physical exercise and sleep time (P<0.05),and was negatively correlated with SDS score,spicy food,course of seborrheic dermatitis and drink wine (P<0.05). Conclusion The HRQOL of seborrheic dermatitis patients is poor.More attentions should be paid to the patients with psychological depression,suffered seborrheic dermatitis more than 3 years,divorced or widowed patients.We should take active treatment with combined Chinese and western medicine to patients,encourage patients to get rid of spicy diet and drink,encourage patients to exercise and ensure adequate sleep time.The above measures all can significantly improve the HRQOL of seborrheic dermatitis patients.