Abstract: Objective To investigate the effects of low-frequency repetitive transcranial magnetic stimulation on the cognitive function and life ability of children with depressive disorder. Methods A total number of 60 children with depression were divided into two groups with 30 cases in each group.The control group treated with Paroxetine,while the experimental group received transcranial magnetic stimulation therapy.The incidence of adverse reactions and the score of HAMD,MMSE,Barthwl index,ASHQ and TESS were compared between the two groups. Results The grade data of the two groups were similar and the difference was not statistically significant (P>0.05).The total efficiency of the experimental group was 93.33%,which was higher than 83.33% of the control group,the difference was not statistically significant (χ²=1.455,P>0.05).After the treatment,the HAMD score and ASHQ score of the two groups were significantly decreased,and the MMSE score and Barthwl index were significantly increased (P<0.05).The HAMD score and ASHQ score of the experimental group were significantly lower than those of the control group after the treatment,the MMSE score and Barthwl index improved significantly,the difference was statistically significant (t=6.451,2.306,6.319,8.819,all P<0.05).The TESS score (2.19±0.65) in the experimental group was significantly lower than that in the control group (3.81±1.27),there was a significant difference (t=6.219,P<0.05).The incidence of adverse reactions in the experimental group (16.67%) was significantly lower than the control group (43.33%),there was a significant difference (χ²=3.889,P<0.05). Conclusion The low frequency transcranial magnetic stimulation in children with depressive disorder can significantly improve the cognitive function and life ability,and the low incidence of adverse reactions.