Abstract: Objective To study the value of umbilical artery blood gas analysis combined with Apgar score in the diagnosis of multiple organ damage after neonatal asphyxia. Methods From November,2014 to March,2016,136 patients with neonatal asphyxia were chosen as study patients,and the umbilical artery blood gas analysis as well as Apgar score was performed in all of them.The ROCs of Apgar score,pH and BE were depicted,and the critical values of Apgar score,pH and BE were confirmed.The specificity,sensitivity and AUC were compared among different indicators. Results In 136 patients with neonatal asphyxia,32 patients (23.52%) were diagnosed with multiple organ damage.The rate of multiple organ damage had significant difference between patients with severe and mild asphyxia (P<0.05),the rate of metabolic acidosis had no significant difference between different patients (P>0.05).The rate of multiple organ damage in patients with severe acidosis was 87.87%(29/33),and in the patients with non-severe acidosis was 6.90%(2/29),that in the patients without acidosis was 1.35%(1/74).One min Apgar score,pH and BE had significant difference between patients with or without multiple organ damage (P<0.05),the difference of 5 min Apgar score had no statistical significance (P>0.05).ROC analysis:The AUC of 1 min Apgar was 0.535,the critical value was 3,the sensitivity was 78.13%,the specificity was 65.38%;these of pH were 0.712,7.05,90.63% and 96.15%,respectively;these of BE were 0.627,-15.23 mmol/L,78.13% and 88.46%,respectively. Conclusion Compared with Apgar score along,the pH and BE of umbilical artery blood could evaluate multiple organ damage after neonatal asphyxia more accurately,which would help increase the accuracy rate of diagnosis.