Abstract: Objective To investigate the use of human albumin in treatment of hypoproteinemia in our hospital,and to provide reference for rational use of drug in the clinic. Methods Using a pharmacy administration software of Haitai,Meikang and HIS,all cases of the human albumin and recipes from January to June in 2015 were reviewed,the irrational drug utilization recipes were summarized by EpiData software and evaluated in accordance with hospital Prescription Evaluation Management Norms(Trial) and Prescription Management Norms. Results Total 342 cases hypoproteinemia were enrolled,and 178 inpatients were prescripted of human albumin,the average hospital stay was 20.5±5.3 days,the average treatment course and consumption of human albumin were 7.6±1.5 days and (63.4±9.6)g,respectively.The respiratory and digestive diseases were the two primary causes of hypoproteinemia.The most of the patients were with a lower level of serum albumin (between 20 g/L and 30 g/L,accounting for 85.4%) before the use of serum albumin.There were 22 cases of irrational prescriptions of human albumin,accounted for 12.4%of the all prescriptions,in which 6 cases were the nonstandard prescriptions that accounted for 27.3%,and 14 cases of unsuitable prescriptions that accounted for 68.2%,and 1 case of abnormal prescriptions that accounted for 4.5%. The amount of 20% human albumin took the majority of irrational albumin prescriptions,while the amount of 5% human albumin took the highest rate of irrational albumin prescriptions. Conclusion Human albumin was used widely in the treatment of hypoproteinemia in our hospital,in which some cases are irrational.We should develop the drug using standard of human albumin and strictly grasp the indications of drug use to promote the safety and rational use of human albumin.