Abstract: Objective The sleep disorder is one of a relative severe symptoms associated with the patients with chronic fatigue syndrome,by using the green,noninvasive,no dependence therapy of Channel Points Massage combined with Yijinjing exercising,we investigated the clinical effect of channel points massage combined with Yijinjing exercising on Chronic fatigue syndrome with sleep disorder. Methods Total 60 cases patients of chronic fatigue syndrome with sleep disorder in our clinic or hospital were recruited and randomly divided into treatment group(30 cases)and control groups(30 cases).The control group received cognitive behavioral therapy,twice a week,40-60 minutes each time,eight weeks were for a course;while the treatment group received channel points massage combined with Yijinjing exercising,three times a week for channel points massage,treatment for every day in the afternoon about 45 minutes,one time a day for Yijinjing exercising,one hour each time,eight weeks were for a course.Both groups were assessed with multidimensional fatigue inventory(MFI-20)and pittsburgh sleep quality index(PSQI)before and after 8 weeks of treatment. Results Before the treatment,there was no significant different in the observed items between the two groups(P>0.05).After 8 weeks of treatment,the treatment group was significant in the scores of general fatigue,physical fatigue,reduced activity,reduced motivation and mental fatigue in multidimensional fatigue inventory(MFI-20)than the control group(P<0.05);the treatment group was significant in pittsburgh sleep quality index(PSQI)than that in the control group(P<0.05). Conclusion Channel points massage combined with Yijinjing exercising can effectively improve the states of fatigue and sleep quality of chronic fatigue syndrome with sleep disorder,the treatment is cheap,simple and effective,it is worthy for the clinical application and popularization of appropriate technology in primary medical institutions.