Abstract: Objective To investigate the clinical features of cytomegalovirus-induced infectious mononucleosis-like syndrome in children. Methods We retrospective1y reviewed the information of 81 children diagnosed with cytomegalovirus-induced infectious mononucleosis-like syndrome in our hospital between January,2010 and December,2014,including their laboratory examine results and clinical data.The data were compared with 30 EB virus induced infectious mononucleosis children. Results A total number of 81 children with mononucleosis-like syndrome caused by CMV(CMV group),aged from 1 to 11 years with an average age of 5.4 years old,the male and female ratio was 1:0.84,were enrolled into this study.The main clinical manifestations of the patients included fever,lymph node enlargement,angina,splenomegaly,palpebral edema,wheezing and so on.When compared with 30 EBV induced infectious mononucleosis children(EBV group),the thermal process of CMV group was (9.15±4.65)days,the difference between two groups was not statistically significant(t=0.979,P>0.05).The length of patient stay in CMV group was (15.88±4.31) days,the difference between two groups was statistically significant(t=2.492,P<0.001).WBC of CMV group was (16.85±6.33)×10⁹/L,the neutral granulocyte count of CMV group was (4.19±2.84)×10⁹/L,and the lymphocyte count was (12.50±6.03)×10⁹/L,the difference between two groups were not statistically significant(t=1.16,t=1.08,t=1.44,P>0.05).The platelet count of CMV group was (260.46±80.69)×10⁹/L,the difference between two groups was statistically significant(t=7.02,P<0.001),as well as the degree of abnormal lymphocytes increased(t=3.814,P<0.001).The increase of abnormal lymphocyte had relationship with the length of stay(F=82.79,P<0.05). Conclusion Fever is the most common clinical manifestations of cytomegalovirus-induced infectious mononucleosis-like syndrome.The liver function damage of infectious mononucleosis-like syndrome caused by cytomegalovirus is better than EBV induced infectious mononucleosis,and the degree of abnormal lymphocytes increased is lower and recovered faster.