Abstract: Objective To detect the serum levels of hypersensitive C-reactive protein(hs-CRP),lipoprotein associated phospholipase A₂(LP-PLA₂)and tryptase(TPS) in patients with hy-pertension.To analyze the correlation of them and hypertension with coronary heart disease,and to explore clinical significance of the three leukocytes in the hypertension with coronary heart disease. Methods A total of 155 patients were participated in the study,all the patients were divided into three groups,pure hypertension group of 75 cases,hypertension with coronary heart disease group of 80 cases,and 48 normal controls enrolled in the study.Using ELISA detect the level of LP-PLA₂,TPS.The differences of the two leukocytes levels between three groups were analyzed.The risk factors of hypertension with coronary heart disease were analyzed with logistic regression analysis,and ROC curve we-re used to evaluate the diagnostic value of hs-CRP,LP-PLA₂ and TPS for coronary heart disease. Results The concentrations of hs-CRP,LP-PLA₂ and TPS in the hypertension with coronary heart disease group were higher than that in the pure hypertension group and the normal controls(P<0.05).Logistic regression analysis demonstrated that hs-CRP,LP-PLA₂,and TPS are the risk factors of hypertension with coronary heart disease(P<0.05).The area under the ROC curve were 0.775,0.656,0.793. Conclusion The serum levels of hs-CRP,LP-PLA₂ and TPS have a certain correlation with hypertension with coronary heart dis-ease.hs-CRP,LP-PLA₂,and TPS are the risk factors of hypertension with coronary heart disease.They could be important forecast factors in the clinical evaluation of hypertension with coronary heart disease.