Abstract: Objective To determine the prevention and risk factors of traumatic cerebral infarction in patients with brain injury,so as to improve its prevention and treatment. Methods Total 277 cases of brain injury patients admitted to our hospital from January,2011 to January,2014 in our hospital were collected.All patients underwent craniotomy,according to whether there was a traumatic cerebral infarction,patients were divided into observation group of 26 cases,251 cases in the control group.Application of single factor analysis of two groups of patients with age,sex,BMI,whether the merger of hypertension,coronary heart disease and admission hyperglycemia,combined injury,cerebral infarction history,mode of operation,type of brain injury,types of cerebral infarction,GCS score,whether complicated with cerebral hernia and whether complicated with malignant brain edema.The risk factors of traumatic cerebral infarction in patients with craniocerebral injury were analyzed by multifactor non-conditional Logistic regression analysis. Results A total of 26 patients complicated with cerebral infarction.The occurrence rate was 9.4%.Preoperative hyperglycemia,subdural hematoma,decompressive craniectomy,GCS less than eight score,combined with cerebral hernia and malignant brain swelling was related with the brain injury after operation occurred(P<0.05). Conclusion Peoperative hyperglycemia,GCS less than eight score,combined with cerebral hernia and associated with malignant brain swelling increase the independent risk factors of traumatic cerebral infarction after craniocerebral injury operation.Intervention should be strengthened in the prevention and treatment of traumatic cerebral infarction after traumatic brain injury.