Abstract: Objective To evaluate the quality of life(QOL) of patients with hepatic cirrhosis and carcinoma,determine the key points of nursing care,and provide a reference for the nursing and health education. Methods Quality of Life Scale and the Functional Assessment of Cancer Therapy Scale were used to survey the QOL among 110 patients(60 cases of hepatic cirrhosis and 50 cases of carcinoma) between April and June in 2014.Epidata 3.02 and SPSS were used to entry and analyze questionnaire data.The non-structured interviews were used to understand the life condition of patients and the received support from family and social. Results Forty percent of patients were with moderate or severe pain and discomfort,43.3% of the patients was with moderate to severe anxiety or depression.Most of the patients were with psychological problems.Lots of patients with liver disease were lack of basic knowledge,and cannot be self-management.The patients in New Rural Co-operative Medical System received less social support as compared with workers and urban residents.18 of 25 patients with New Rural Co-operative Medical System were not supported by friends,whole only 3 of 72 cases urban workers and urban residents were not supported by friends,the difference was statistically significant(P<0.05).However,in family and other supports,there was no significant difference between patients with the New Rural Co-operative Medical System and urban workers and urban residents. Conclusion The nursing care for specific lesions and psychological nursing care for the patients with hepatic cirrhosis and carcinoma should be paid more attentions.The medical facilities should promote the targeted healthy knowledge education for patients,and concern the liver disease group,and encourage them to obtain social support actively.