Abstract: Objective To investigate the clinical efficacy of Xipayi collutory combined with Shuanghuanglian granules in the treatment of recurrent oral ulcer. Methods Total 166 cases of recurrent oral ulcer in our hospital between January,2014 and December,2015 were enrolled and randomly divided into 2 groups with 83 cases in each group.The patients in the control group were given Xipayi collutory,while the patients in the observation group were given additional Shuanghuanglian granules on the basis of Xipayi collutory.The patients in the two groups were treated for 5 days.Before and after the treatment,serum tumor necrosis factor-α(TNF-α),interleukin-2(IL-2) and interleukin-6(IL-6) levels of both groups were detected.The ulcer status and pain degree of the two groups were accounted.SPSS statistical software was used to analyze the difference in the therapeutic efficacy between the two groups. Results After the treatment,TNF-α and IL-6 levels of both groups were significantly reduced(P<0.05),and TNF-α and IL-6 levels of the observation group was significantly lower than that of the control group(P<0.05).After the treatment,IL-2 levels of the two groups were significantly elevated(P<0.05),and IL-2 level of the observation group was significantly higher than that of the control group(P<0.05).The ulcer diameter and pain degree of the observation group was significantly lower than those in the control group(P<0.05).The total efficacy rate of the observation group was 89.5%,which was significantly higher than the control group(75.6%),P<0.05. Conclusion Xipayi collutory combined with Shuanghuanglian granules can effectively reduce the inflammatory reaction,ulcer status and pain degree in patients with recurrent oral ulcer,with a satisfactory efficacy,which is worthy of promotion.