Abstract: Objective To analyze the influence of different doses of Atorvastatin on high sensitivity C-reactive protein and soluble vascular cell adhesion molecule 1 in patients with coronary atherosclerotic heart disease(CHD) combined with hyperlipidemia. Methods Total 100 cases were selected and randomly divided into 40 mg Atorvastatin calcium group(A,50 cases,half unstable angina and half myocardial infarction) and 20 mg Atorvastatin calcium group(B,50 cases,half unstable angina and half myocardial infarction).Before and after 4 weeks and 12 weeks treatment,the serum total cholesterol(TC),high-sensitivity C-reactive protein(hs-CRP) and soluble vascular cell adhesion molecule 1(sVCAM-1) level was tested,and the major adverse drug reaction were recorded. Results No statistical significant difference was found about TC,hs-CRP,sVCAM-1 between group A and group B before Atorvastatin treatment(P>0.05),there was significant difference about hs-CRP,sVCAM-1 in patients with myocardial infarction compared with unstable angina before Atorvastatin treatment(P<0.05);There was significant difference about TC after 4 weeks and 12 weeks treatment compared with before treatment in each group(P<0.05).And A group had the remarkable significance with B group of TC level(P<0.05);There was significant difference about hs-CRP,sVCAM-1 after 12 weeks treatment compared with before and after 4 weeks treatment in group A(P<0.05).There was no obvious adverse drug reaction in each group. Conclusion High doses of Atorvastatin is safe and effective in patients with coronary atherosclerotic heart disease combined with hyperlipidemia,it can significantly decrease blood cholesterol and inflammatory factors levels and may stabilize atherosclerotic plaque.Atorvastatin might play a role in the prevention of CHD.