Abstract: Objective To observe the effect of effectiveness and safety of docetaxel(DCT) combined with cisplatin(CDDP) by different approach in the treatment of cervical carcinoma(CC). Methods Total 90 patients with CC in our hospital between May,2010 and July,2014 were selected,45 patients received DCT combined with CDDP chemotherapy were as the control group,while 45 cases received DCT combined with CDDP arterial infusion chemotherapy(AIC) were as the observation group.The effect was evaluated after the treatment,and the remission of parametrial invasion,salvage surgery after chemotherapy,postoperative recurrence as well as adverse reactions were followed up. Results The efficacy in the observation group was 91.1%(41/45),while in the control group was 80.0% (36/45),the difference was significant(P<0.05);the remission rate after the chemotherapy,postoperative chemotherapy rate,postoperative recurrence in the observation group were 82.2%(37/45),75.6%(34/45) and 4.4%(2/45),while in the control group was 66.7%(30/45),73.3%(33/45) and 4.4%(2/45),the remission rate after the chemotherapy in the observation group was significantly higher as compared with the control group,while the difference in the postoperative chemotherapy rate,postoperative recurrence was not statistically significant(P>0.05);the incidence of bone marrow suppression,gastrointestinal reactions,neurotoxicity was significantly lower in the observation group than that in the control group(P<0.05). Conclusion DCT combined with CDDP chemotherapy in the treatment of CC has a good short-term efficacy,and the incidence rate of adverse reactions is lower,it is a safe and effective treatment for CC.