Abstract: Objective To study the relationship between urinary iodine level and clinical pathology in patients with thyroid nodule,and to guide scientific iodine supplementation for local citizen. Methods A total of 98 patients of Beilun district in Zhejiang in our hospital between June，2012 and January，2014 were detected for urine iodine concentration by arsenic-cerium catalytic spectrophotometry.Meanwhile 325 normal people were set as the control group. Results The median urinary iodine of our district was 135.2 μg/L of adequate iodine intake level.There was no significant difference in urinary iodine among different age-sex group in thyroid node patients(P=0.23，P=0.18).MUI of benign thyroid nodules (nodular goiter,thyroid adenoma) and thyroid cancer was 155.9 μg/L and 149.5 μg/L respectively.There were no significant difference among benign thyroid nodules,thyroid cancer and the control group(P=0.88，P=0.59，P=0.59).MUI of patients with lymph node metastasis was higher than that in patients without lymph node metastasis(P=0.04). Conclusions The Iodine nutrition of people in Beilun district is in adequate iodine intake level.There is no obvious relationship between Iodine nutrition and the incidence of thyroid node.The local citizen may continue the current iodine intake.However,there is an obvious relationship between high MUI and thyroid cancer patients with lymph node metastasis,promote that those patients should limit iodized salt intake appropriately.