Abstract: Objective To investigate the effect of different doses of Radix curcumae extract onexpression of P-P38and pain threshold of CCI rats. Methods Thirty-six healthy adult male SD rats,weight 250-250 g,were chosen.To establish the CCI rat model,the SD rats were divided into normal group,model group,radix curcumae extract low,middle and high dose group,and gabapentin group and solvent group,and all of rats in each group were measured thermal paw withdrawal latency,using Western blot detection of rat L₄-L₆ spinal cord of P-P38 expression. Results ①Compared with the normal group,rats TWL value decreased significantly(P<0.05),indicating that neuropathic model was successfully built.Compared with the solvent group,Curcuma aromatica extract high dose group can significantly increased in CCI rats TWL value(P<0.01).②After modeling,L₄-L₆ spinal cord in rats of P-P38 expression of gray value and the ratio of reference into an upward trend,compared with normal group increased significantly(P<0.01);compared with the solvent group,curcuma aromatica extract high dose group and gabapentin group can significantly reduce the L₄-L₆ spinal cord of P-P38 expression(P<0.01). Conclusion High dose of Radix curcumae extract may play a role in neuropathic pain through reducing the expression of P-P38 in spinal cord of CCI model rats.