Abstract: Objective To investigate the effect of ursodeoxycholic acid(UDCA) combined withs-adenosylmethionine(SAM) in the treatment of intrahepatic cholestasis of pregnancy(ICP). Methods A total of 134 patients in the Department of Obstetrics and Gynecology between January 2010 and October 2015 were taken into this research and were divided into OBG(66 patients)and COG(68 patients)group according to random number table.The patients in OBG group received UDCA and SAM,while the COG group received the conventional treatment.The biochemical markers of liver and delivery conditions in two groups were compared. Results In OBG Group,there were 34(50.75%)cases of spontaneous labor(χ²=8.562,P=0.019),4(11.76%)cases of artificial aiding-birth(χ²=9.025,P=0.014),33(49.25%) cases of caesarean section(χ²=8.747,P=0.026),67(100%)fetal survived(χ²=8.637,P=0.009).The levels of TBil(t=16.562,P=0.035),ALP(t=18.935,P=0.024),γ-GT(t=19.025,P=0.015),TBA(t=19.365,P=0.012) and ALT (t=16.253,P=0.035) after the treatment in OBG Group recovered,which were significantly better than CTG Group(P<0.05). Conclusion Ursodeoxycholic acid and s-adenosylmethioninein the treatment of intrahepatic cholestasis of pregnancy can obviously improve thebiochemical markers of liver,promote the healthy pregnancy and natural childbirth,and improve the prognosis of patients,which is worthy of clinical use.