Abstract: Objective To assess the curative effect of aerobic exercise in the elderly patients with arteriosclerosis obliterans(ASO) of the lower extremity undergoing non-interventional therapy. Methods A total of 65 patients with ASO of the lower extremity undergoing non-interventional therapy were enrolled and randomly assigned to study group and control group.The 6-min walk test(6MWT),cardiopulmonary exercise testing(CPET) assessment and ankle brachial index(ABI) detection were performed in both groups.The control group received the routine treatment,while the study group received additional aerobic exercise for three months.6MWT,CPET and ABI were rechecked after the treatment. Results In the study group,the walking distance increased by 75.75 m,claudication distance increased by 71.4 m,VO_2peak increased 169.2 ml/min[2.46 ml/(kg·min)],AT value increased 2.19 ml/kg·min,the metabolic equivalent increased 0.5 METs,and ABI values increased by 0.08,the difference were significantly as compared with the values before exercise intervention(P＜0.05).After the treatment,the difference in the above indexes between the two groups were significantly different(P＜0.05). Conclusion The aerobic exercise under the guidance of the individualized exercise prescription can effectively improve symptoms,walking distance,exercise endurance and ABI values in the elderly patients with h ASO of the lower extremity undergoing non-interventional therapy.