Evaluation of right heart function in patients with type 2 diabetes mellitus
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摘要: 目的 应用超声心动图技术测量2型糖尿病患者右心各指标,探讨患者右心结构及功能随糖尿病病程发展的变化。 方法 根据糖尿病诊断标准,将149例临床诊断为2型糖尿病患者根据有无微血管病变,分为糖尿病无微血管病变组(T2DM-Ⅰ)70例和糖尿病合并微血管病变组(T2DM-Ⅱ)79例,同时选取90名健康成人为对照组。所有受试者行超声心动图检查,比较3组之间的右心室舒张、收缩功能指标及右心房、室大小指标。 结果 2组糖尿病患者E/A较正常对照组均显著降低,差异有统计学意义(P<0.01),T2DM-Ⅱ组较T2DM-Ⅰ组E/E’比值增加、T2DM-Ⅰ组较正常对照组E/E’比值增加,差异有统计学意义(P<0.05),T2DM-Ⅱ较正常对照组E/E’比值明显增加,差异有统计学意义(P<0.01);T2DM-Ⅱ组的RV-strain和Tei指数与T2DM-Ⅰ组及正常对照组比较差异有统计学意义(P<0.01),3组间比较FAC和TAPSE指标差异无统计学意义(P>0.05);T2DM-Ⅰ、Ⅱ两组除RVWT各组间比较差异有统计学意义外(P<0.01),其余右心房室构型指标较正常对照比较差异无统计学意义(P>0.05)。 结论 2型糖尿病患者随着病程的发展,右室心肌功能的变化早于右心构型的改变,且右心室舒张功能的降低明显早于收缩功能的减退。Abstract: Objective To evaluate the right heart functions in patients with type 2 diabetes mellitus(T2DM)by echocardiography,and to find out the correlation between echocardiographic findings and the severity of T2DM. Methods A total of 149 patients with T2DM were selected and divided into the non-diabetic microangiopathy group(70 cases,T2DM-Ⅰ)and the diabetic microangiopathy group(79 cases,T2DM-Ⅱ)according to the diagnostic criteria of T2DM.And 90 healthy age-matched volunteers were selected as controls.All subjects underwent echocardiography.The right ventricular size and function were compared among the three groups. Results Tricuspid orifice E/A of Two T2DM groups were lower than that of the control group (P<0.01);Tricuspid E/E’ was significantly different between T2DM-Ⅰand the control group(P<0.05),and it was significantly different between T2DM-Ⅱand the control group(P<0.01)as well.There were also significant differences of RV-strain and Tei index in the T2DM-Ⅱ as compared with T2DM-Ⅰand the control group(P<0.01).There were no significant differences in FAC and TAPSE among the three groups(P>0.05).The indexes except RVWT between T2DM-Ⅱ and T2DM-Ⅰ were significant difference (P<0.01).The right ventricular size and function were not significant difference(P>0.05). Conclusion With the development of diabetes,the functional impairment of the right heart appears earlier than structural changes,and right ventricular diastolic function is early impaired than the systolic function.
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Key words:
- Echocardiography /
- Diabetes mellitus /
- Microangiopathy /
- Right heart function
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