Abstract: Objective To investigate the prenatal ultrasound screening for fetal congenital heart disease (CHD) value,analysis of risk factors influencing the occurrence of CHD. Methods One thousand seven hundred and ninety-two cases of pregnant women for prenatal ultrasound screening for fetal congenital heart disease were retrospectively analyzed in our hospital from January 2011 to August 2014，compared with prenatal ultrasound screening results and autopsy after delivery system,ultrasound examination results; a total of 50 cases of ultrasound diagnosis of pregnant women with CHD,150 cases of pregnant women with CHD,“Questionnaire” risk factors of congenital heart disease combined with the existing literature screening for risk factors of CHD,by single factor and multiple factor Logistic regression analysis of risk factors of CHD. Results Prenatal ultrasound diagnosis of CHD in 72 cases of pregnant women,postpartum echocardiography examination confirmed 9 cases,2 cases were misdiagnosed as atrial septal defect,61 cases confirmed by autopsy; single factor Logistic regression analysis,advanced maternal age,maternal cold,CHD family history,history of adverse pregnancy,gestational diabetes,chromosome abnormalities,abnormal amniotic fluid volume,pregnant women smoking or passive smoking,viruses or chemicals and early pregnancy,history of adverse life events such as the 10 factor is CHD disease risk factors;multivariate Logistic regression analysis,found that maternal cold,CHD family history,pregnancy history,chromosome abnormalities,abnormal amniotic fluid volume and maternal smoking or passive smoking 6 major factors are risk factors for the CHD. Conclusion Prenatal ultrasound screening for fetal congenital heart disease is a noninvasive diagnostic method,efficient,for the risk factors of pregnant women,the timely implementation of prenatal ultrasound screening for early intervention and reduce the birth rate of CHD,has an important significance in eugenics.