Abstract: Objective To Analyze the effect of autologous blood transfusion replacement on the blood clotting,immune function of patients with total hip arthroplasty. Methods From August 2013 to March 2015 90 cases of total hip arthroplasty patients in our hospital were chosen,according to the number table all the patients were randomly divided into two groups(autologous blood transfusion therapy) and control group(row allogeneic blood transfusion NOTE treatment).Both groups were recorded amount of autologous blood transfusion,allogeneic blood transfusion,postoperative drainage,venous blood monitoring all patients,blood and coagulation Checker 2 h,24 h after transfusion,preoperative and postoperative 1 d,3 d of T lymphocyte subsets CD3⁺,CD4⁺,CD8⁺,natural killer cells(NK cells),calculated CD4⁺/CD8⁺ value,and LgM,LgG,TNF-α values. Results Hb,Hct,PTL,APTT,ACT indicators in the two groups of patients before transfusion were lower than 24 h operation,two indicators have 2 h after blood transfusion after transfusion 24 h relatively improved,but were lower than the preoperative,and the difference statistically significant(P＜0.05);the two groups after transfusion 2 h PT higher than before surgery,24 h were decreased after transfusion;transfusion after two FIB level lower than the preoperative value,less than 24 h after transfusion after transfusion 2 h,but lower than that before surgery,the difference was statistically significant(P＜0.05).After the transfusion 24 h of CD3⁺,CD4⁺,CD4⁺/CD8⁺,NK cell index compared with surgery significantly reduced allogeneic blood transfusion group,but CD8⁺ slightly increased after transfusion 72 h allogeneic transfusion group CD3⁺,CD4⁺,CD4⁺/CD8⁺,the number of NK cells continue to reduce,CD8⁺ value slightly increased,the difference was statistically significant(P＜0.05).Preoperative LgM,LgG,TNF-α levels were not significant differences(P＞0.05);two groups after 24 h,72 h of LgM,LgG were lower than the preoperative,and the difference statistically significant(P＜0.05);observation group after 24 h,72 h of LgM,LgG,TNF-α levels were higher values(P＜0.05). Conclusion Autologous blood transfusion has little effect on immune function,and the blood shortage problem solve and prevent undesirable complication of allogeneic blood transfusion caused the occurrence.