Application of IoT-based respiratory rehabilitation in patients with community-acquired pneumonia
-
摘要:
目的 探讨基于物联网技术的呼吸康复训练对社区获得性肺炎患者临床症状、肺功能及实验室检查的影响。 方法 选取2023年7月—2024年12月就诊于河北省某三甲医院诊断为社区获得性肺炎的176例患者为研究对象,根据随机数字表法分为试验组和对照组,每组88例。对照组实施常规治疗和护理,试验组在对照组的基础上应用呼吸训练器进行呼吸训练。分别于干预前、干预7 d后、干预14 d后对2组患者的生理指标、临床症状、实验室检查、胸部CT平扫、肺功能、是否发生不良事件进行比较。 结果 干预7 d后,试验组C反应蛋白[6.00(3.00, 11.00)mg/L vs. 6.00(5.00, 15.00)mg/L]、降钙素原[0.03(0.02, 0.05)ng/mL vs. 0.03(0.02, 0.08)ng/mL]、第1秒用力呼气容积[FEV1,2.56(1.96, 3.20)L vs. 2.23(1.03, 2.78)L]、最大吸气压[MIP,50(36, 71)cmH2O vs. 41(32, 64)cmH2O,1 cmH2O=0.098 kPa]、咳嗽程度评分[CET,7(7, 8)分vs. 10(9, 11)分]均优于对照组(P < 0.05)。干预14 d后试验组FEV1[2.83(2.15, 3.44)L vs. 2.59(1.84, 3.14)L]、用力呼气肺总量[FVC,4.10(3.28, 5.02)L vs. 3.17(2.38, 4.06)L]、MIP[64(52, 78)cmH2O vs. 60(46, 72)cmH2O]、最大呼气压[MEP,88(76, 117)cmH2O vs. 80(62, 108)cmH2O]均优于对照组(P < 0.05)。干预期间,2组患者均无不良事件发生。 结论 基于物联网技术的呼吸康复训练对社区获得性肺炎患者改善临床症状、提高肺功能具有积极作用。 Abstract:Objective To investigate the effects of Internet of Things (IoT)-based respiratory rehabilitation training on clinical symptoms, pulmonary function, and laboratory parameters in patients with community-acquired pneumonia (CAP). Methods A total of 176 CAP patients admitted to a Level A Tertiary hospital in Hebei Province between July 2023 and December 2024 were enrolled in the study, and assigned to either an experimental group (n=88) or a control group (n=88) using a random number table method. The two groups received standard medical care; however, the experimental group also additionally underwent IoT-based respiratory training with a portable breathing device. A comprehensive evaluation of the clinical outcomes was conducted, encompassing various parameters, such as physiological indicators, the severity of symptoms, laboratory markers, imaging findings, pulmonary function and nutritional status. These outcomes were assessed at three distinct time points: baseline, 7 days post-intervention, and 14 days post-intervention. Results At the 7-day follow-up, the experimental group exhibited significant improvements compared to controls in CRP reduction [6.00 (3.00, 11.00) mg/L vs. 6.00 (5.00, 15.00) mg/L], PCT normalization [0.03 (0.02, 0.05) ng/mL vs. 0.03 (0.02, 0.08) ng/mL], forced expiratory volume in the first second [FEV1, 2.56 (1.96, 3.20) L vs. 2.23 (1.03, 2.78) L], maximum inspiratory pressure [MIP, 50 (36, 71) cmH2O vs. 41 (32, 64) cmH2O, 1 cmH2O=0.098 kPa], and cough severity scores [7 (7, 8) vs. 10 (9, 11), P < 0.05]. By day 14, further enhancements were observed in FEV1 [2.83 (2.15, 3.44) L vs. 2.59 (1.84, 3.14) L], forced vital capacity [FVC, 4.10 (3.28, 5.02) L vs. 3.17 (2.38, 4.06) L], MIP [64 (52, 78) cmH2O vs. 60 (46, 72) cmH2O], maximum expiratory pressure [MEP, 88 (76, 117) cmH2O vs. 80 (62, 108) cmH2O] with all comparisons showing statistical significance (P < 0.05). During the intervention period, no adverse reactions occurred in either the experimental group or the control group. Conclusion The findings of this study demonstrate that IoT-facilitated respiratory rehabilitation effectively alleviates systemic inflammation, improves pulmonary mechanics, and accelerates clinical recovery in CAP patients. -
表 1 呼吸训练方案
Table 1. Respiratory training program
阶段(干预时间: 地点) 具体内容 方式(频次) 在院(7 d: 病房) 1.干预前行简易肺功能测定 护士床旁监督指导完成(2次/d,每次时间约15~20 min) 2.每次训练包括吸气训练、呼气训练,痰液较多或痰液不易咳出者加做气道廓清训练 3.吸气训练和呼气训练的难度设置均采用自动模式,从一档开始训练,前三次吸气/呼气无阻力,第四次开始系统自动增加阻力,阻力增加的大小随难度挡位的增加而递增; 训练次数设置以患者稍感费力但不疲劳为宜 4.气道廓清采用手动模式,训练阻力设置一般由高到低,咳嗽频繁或剧烈可适当降低阻力; 呼吸训练器固有频率设置可依据患者训练时的自主频率而变化,固有频率与患者自主频率相同时排痰效果最好; 每次排痰前需要在深吸气后屏气2~3 s 5.7 d结束时行简易肺功能测定 院外(7 d: 居家) 1.按出院时的各项参数继续训练,训练期间可根据疾病恢复情况调整训练参数 居家自行训练(2次/d,每次约15~20 min) 2.护士每日下午下班前调取患者数据并记录 3.单项训练次数少于住院时训练次数或训练成绩明显低于住院时成绩的,护士微信或电话随访原因并指导 4.训练结束时行简易肺功能测定 表 2 2组CAP患者一般资料比较
Table 2. Comparison of general data betwen two groups of CAP patients
组别 例数 年龄
(x±s,岁)性别(例) 吸烟史(例)c BMI
[M(P25, P75)]慢病种类
[M(P25, P75),种]男性 女性 是 否 试验组 88 56.60±11.71 49 39 35 53 23.9(21.7, 25.0) 1(0, 1) 对照组 88 55.40±10.81 50 38 23 26 23.7(21.9, 25.0) 1(0, 1) 统计量 0.706a 0.023b 3.703b -0.491d -0.700d P值 0.481 0.879 0.054 0.623 0.484 注: a为t值,b为χ2值,d为Z值; c代表一生中连续或累积吸烟6个月及以上者定义为有吸烟史。 表 3 干预前及干预7 d后2组CAP患者生理指标、实验室检查、影像学、临床症状比较[M(P25, P75)]
Table 3. Comparison of physiological indicators, laboratory tests, imaging, and clinical symptoms of CAP patients between the two groups before intervention and 7 days after intervention[M(P25, P75)]
项目 时间 试验组(n=88) 对照组(n=88) Z值 P值 呼吸频率(次/min) 干预前 21(20, 22) 21(20, 22) -0.750 0.453 干预后 19(18, 20)a 19(18, 20)a -1.891 0.059 脉率(次/min) 干预前 92(80, 97) 92(80, 96) -0.656 0.512 干预后 78(75, 80)a 78(72, 80)a -0.841 0.401 末梢血氧饱和度(%) 干预前 92(92, 93) 93(92, 93) -1.031 0.302 干预后 96(95, 97)a 96(95, 97)a -0.437 0.662 WBC(×109/L) 干预前 9.53(7.52, 12.14) 9.00(7.19, 13.37) -0.425 0.671 干预后 8.06(7.59, 9.07)a 7.93(7.06, 8.79)a -1.919 0.055 CRP(mg/L) 干预前 25.50(13.50, 66.00) 18.00(9.50, 60.50) -1.002 0.316 干预后 6.00(3.00, 11.00)a 6.00(5.00, 15.00)a -1.966 0.046 PCT(ng/mL) 干预前 0.06(0.03,0.09) 0.03(0.04, 0.09) -1.658 0.097 干预后 0.03(0.02,0.05)a 0.03(0.02,0.08)a -2.072 0.038 影像学 干预后 2(1, 2) 2(1, 2) -0.106 0.915 mMRC(分) 干预前 1(0, 2) 1(0, 2) -0.852 0.394 干预后 0(0, 1)a 0(0, 1)a -1.840 0.066 CET(分) 干预前 13(11, 18) 15(14, 16) -0.202 0.840 干预后 7(7, 8)a 10(9, 11)a -10.807 <0.001 注: 与同组干预前比较,aP<0.05;影像学结果1代表好转,2代表无变化。 表 4 干预前及干预7 d后2组CAP患者肺功能检查比较[M(P25, P75)]
Table 4. Comparison of pulmonary function tests between the two groups of CAP patients before intervention and 7 days after intervention[M(P25, P75)]
项目 时间 试验组(n=88) 对照组(n=88) Z值 P值 FEV1(L) 干预前 2.13(1.43, 2.67) 2.02(0.92, 2.64) -1.697 0.090 干预后 2.56(1.96, 3.20)a 2.23(1.03, 2.78)a -2.007 0.045 FVC(L) 干预前 2.79(2.36, 3.86) 2.80(1.33, 3.72) -1.266 0.205 干预后 3.35(2.52, 4.04)a 3.08(1.61, 3.90)a -1.212 0.226 MIP(cmH2O) 干预前 42(24, 49) 30(23, 46) -1.845 0.065 干预后 50(36, 71)a 41(32, 64)a -2.345 0.019 MEP(cmH2O) 干预前 69(53, 100) 69(53, 100) -0.742 0.458 干预后 82(59, 117)a 76(55, 96)a -1.385 0.166 PIF(L/min) 干预前 193(169, 225) 194(173, 233) -0.324 0.746 干预后 285(256, 334)a 276(225, 327)a -1.203 0.229 PEF(L/min) 干预前 349(268, 488) 360(253, 517) -0.394 0.694 干预后 356(262, 538)a 376(256, 538)a -0.118 0.906 注: 与同组干预前比较,aP<0.05。1 cmH2O=0.098 kPa。 表 5 干预前及干预14 d后2组CAP患者生理指标、实验室检查、影像学、临床症状比较[M(P25, P75)]
Table 5. Comparison of physiological indicators, laboratory tests, imaging, and clinical symptoms of CAP patients between the two groups before intervention and 14 days after intervention[M(P25, P75)]
项目 时间 试验组(n=82) 对照组(n=84) Z值 P值 呼吸频率(次/min) 干预前 21(20, 22) 21(20, 22) -0.750 0.453 干预后 19(18, 20) 19(18, 20) -1.014 0.310 脉率(次/min) 干预前 92(80, 97) 92(80, 96) -0.656 0.512 干预后 75(72, 76) 75(68, 76) -0.772 0.440 末梢血氧饱和度(%) 干预前 92(92, 93) 93(92, 93) -1.031 0.302 干预后 96(96, 97) 96(96, 97) -0.205 0.838 WBC(×109/L) 干预前 9.53(7.52, 12.14) 9.00(7.19, 13.37) -0.425 0.671 干预后 7.62(7.05, 8.24) 6.39(5.80, 7.05) -3.397 0.061 CRP(mg/L) 干预前 25.50(13.50, 66.00) 18.00(9.50, 60.50) -1.002 0.316 干预后 6.50(5.00, 8.00) 7.00(5.00, 8.00) -0.925 0.355 影像学 干预后 1(1, 1) 1(1, 1) < 0.001 0.999 mMRC(分) 干预前 1(0, 2) 1(0, 2) -0.852 0.394 干预后 0(0, 1) 0(0, 1) -1.275 0.202 CET(分) 干预前 13(11, 18) 15(14, 16) -0.202 0.840 干预后 7(7, 8) 8(7, 9) -1.106 0.281 注: 影像学1代表好转,2代表无变化。 表 6 干预前及干预14 d后2组CAP患者肺功能检查比较[M(P25, P75)]
Table 6. Comparison of pulmonary function tests between the two groups of CAP patients before intervention and 14 days after intervention[M(P25, P75)]
项目 试验组(n=82) 对照组(n=84) Z值 P值 FEV1(L) 干预前 2.10(1.43, 2.67) 2.02(0.92, 2.64) -1.697 0.090 干预后 2.83(2.15, 3.44)a 2.59(1.84, 3.14)a -2.540 0.011 FVC(L) 干预前 2.79(2.36, 3.86) 2.80(1.33, 3.72) -1.266 0.205 干预后 4.10(3.28, 5.02)a 3.17(2.38, 4.06)a -4.913 <0.001 MIP(cmH2O) 干预前 42(24, 49) 30(23, 46) -1.845 0.065 干预后 64(52, 78)a 60(46, 72)a -1.963 0.046 MEP(cmH2O) 干预前 69(53, 100) 69(53, 100) -0.884 0.377 干预后 88(76, 117)a 80(62, 108)a -2.058 0.040 PIF(L/min) 干预前 195(169, 229) 195(165, 231) -0.120 0.905 干预后 284(240, 333)a 291(236, 339)a -0.491 0.623 PEF(L/min) 干预前 349(274, 502) 373(287, 517) -1.021 0.307 干预后 382(278, 538)a 379(278, 508)a -0.005 0.996 注: 与同组干预前比较,aP<0.05。 -
[1] 李群, 吕允相, 夏申宏, 等. 血清PCT、CRP和IDO水平在预测社区获得性肺炎患者预后中的临床价值[J]. 中华全科医学, 2024, 22(3): 460-463, 512. doi: 10.16766/j.cnki.issn.1674-4152.003426LI Q, LYU Y X, XIA S H, et al. The clinical value of serum PCT, CRP and IDO levels in predicting the prognosis of patients with community-acquired pneumonia[J]. Chinese Journal of General Practice, 2024, 22(3): 460-463, 512. doi: 10.16766/j.cnki.issn.1674-4152.003426 [2] REGUNATH H, OBA Y. Community-acquired pneumonia[M]. In: StatPearls. Treasure Island (FL): StatPearls Publishing, 2024. [3] RYRS∅ C K, FAURHOLT-JEPSEN D, RITZ C, et al. Effect of exercise training on prognosis in community-acquired pneumonia: a randomized controlled trial[J]. Clin Infect Dis, 2024, 78(6): 1718-1726. doi: 10.1093/cid/ciae147 [4] 吴雪娟, 纪柳煌, 蒋文虹, 等. 物联网呼吸康复系统对GOLD3期慢性阻塞性肺疾病患者的应用效果[J]. 中国医药科学, 2024, 14(16): 147-150.WU X J, JI L H, JIANG W H, et al. The application effect of the Internet of Things respiratory rehabilitation system on patients with GOLD3 stage chronic obstructive pulmonary disease[J]. Chinese Medical Science, 2024, 14(16): 147-150. [5] 李丽轩, 梁洪, 范勇, 等. 基于物联网和可穿戴技术的智能监护系统研发及其应用模式探索研究[J]. 生物医学工程学杂志, 2023, 40(6): 1053-1061.LI L X, LIANG H, FAN Y, et al. Research and Development of Intelligent Monitoring System Based on Internet of Things and Wearable Technology and exploration of its application mode[J]. Journal of Biomedical Engineering, 2023, 40(6): 1053-1061. [6] 宋晓玲, 吴素红, 李道帆, 等. 老年社区获得性肺炎急性期患者细胞免疫功能状态及其临床意义[J]. 湖南师范大学学报(医学版), 2022, 19(4): 98-100.SONG X L, WU S H, LI D F, et al. Cellular immune function status and its clinical significance in elderly patients with acute community-acquired pneumonia[J]. Journal of Hunan Normal University (Medical Science Edition), 2022, 19(4): 98-100. [7] 朱丽萍, 丁航海, 李宏辉. 血清CRP、PA、SAA及CRP/PA对老年脑卒中患者隐性吸入性肺炎的预测价值及与肺炎严重程度的关系[J]. 临床心身疾病杂志, 2023, 29(5): 46-51.ZHU L P, DING H H, LI H H. The predictive value of serum CRP, PA, SAA and CRP/PA for latent aspiration pneumonia in elderly stroke patients and their relationship with the severity of pneumonia[J]. 临床心身疾病杂志, 2023, 29(5): 46-51. [8] 林昱, 汪华, 李鹏. 热毒宁联合头孢哌酮/舒巴坦钠和替加环素对泛耐药鲍氏不动杆菌肺炎的抑菌效果[J]. 中华医院感染学杂志, 2022, 32(3): 331-335.LIN Y, WANG H, LI P. The antibacterial effect of Retuning combined with cefoperazone/sulbactam sodium and tigecycline on pan-drug-resistant Acinetobacter baumannii pneumonia[J]. Chinese Journal of Nosocomiology, 2022, 32(3): 331-335. [9] RIZO-TÉLLEZ S A, SEKHERI M, FILEP J G. C-reactive protein: a target for therapy to reduce inflammation[J]. Front Immunol, 2023, 14: 1237729. DOI: 10.3389/fimmu.2023.1237729. [10] ZHOU J D, SONG J, GONG S J, et al. Lung ultrasound combined with procalcitonin for a diagnosis of ventilator-associated pneumonia[J]. Respir Care, 2019, 64(5): 519-527. doi: 10.4187/respcare.06377 [11] 靳蓉晖, 方威, 赵建军, 等. 基于GOLD分级的肺康复训练在慢性阻塞性肺疾病急性加重期患者中的应用研究[J]. 中华现代护理杂志, 2022, 28(35): 4915-4920.JIN R H, FANG W, ZHAO J J, et al. Application research of Pulmonary Rehabilitation Training Based on GOLD Classification in Patients with Acute Exacerbation of Chronic obstructive Pulmonary Disease[J]. Chin J Mod Nurs, 2022, 28(35): 4915-4920. [12] 艾姚含, 李鸣, 杜军, 等. 呼吸康复训练对病毒感染后肺炎患者的疗效评估[J]. 结核与肺部疾病杂志, 2024, 5(S1): 38-41.AI Y H, LI M, DU J, et al. Evaluation of the therapeutic effect of respiratory rehabilitation training on patients with post-viral pneumonia[J]. Journal of Tuberculosis and Pulmonary Diseases, 2024, 5(S1): 38-41. [13] 谢建萍. 呼吸康复训练在肺部感染患者康复过程中的应用价值[J]. 中国现代药物应用, 2024, 18(24): 155-157.XIE J P. The application value of respiratory rehabilitation training in the rehabilitation process of patients with pulmonary infection[J]. Modern Chinese Medicine Application, 2024, 18(24): 155-157. [14] 穆彦熹, 姚亚龙, 李金洲, 等. 术前吸气肌训练在腹部外科中的意义及前景[J]. 中华全科医学, 2023, 21(1): 118-122. doi: 10.16766/j.cnki.issn.1674-4152.002826MU Y X, YAO Y L, LI J Z, et al. The significance and prospects of preoperative inspiratory muscle training in abdominal surgery[J]. Chinese Journal of General Practice, 2023, 21(1): 118-122. doi: 10.16766/j.cnki.issn.1674-4152.002826 [15] 朱蕾, 陈荣昌. 成人常规肺功能测定规范中国专家共识[J]. 临床肺科杂志, 2022, 27(11): 1621-1633.ZHU L, CHEN R C. Chinese Expert Consensus on Standards for Routine Pulmonary Function Testing in Adults[J]. Journal of Clinical Pulmonology, 2022, 27(11): 1621-1633. [16] 孟利娥, 马佳瑞, 张丽, 等. 成人肺炎支原体肺炎、非肺炎支原体肺炎临床对比观察[J]. 山东医药, 2024, 64(36): 76-78.MENG L E, MA J R, ZHANG L, et al. Clinical comparative observation of Mycoplasma pneumoniae Pneumonia and non-Mycoplasma pneumoniae pneumonia in adults[J]. Shandong Medical Journal, 2024, 64(36): 76-78. [17] ZAPATA-SORIA M, CABRERA-MARTOS I, HEREDIA-CIURÓ A, et al. Effects of home-based daily respiratory muscle training on swallowing outcomes in patients with chronic stroke: protocol for a randomized controlled trial[J]. J Clin Med, 2024, 13(18): 5547. DOI: 10.3390/jcm13185547. [18] HARTMAN M, DOSBABA F, BATALIK L, et al. Home-based inspiratory muscle training as stand-alone therapy in COPD: a randomized sham-controlled trial assessing novel and established training methods[J]. COPD, 2025, 22(1): 2487473. DOI: 10.1080/15412555.2025.2487473. [19] ZENG Y Q, WU Q, CHEN Y, et al. Early comprehensive pulmonary rehabilitation for hospitalized patients with acute ex-acerbation of chronic obstructive pulmonary disease: a randomized controlled trial[J]. J Rehabil Med, 2024, 56: jrm39953. DOI: 10.2340/jrm.v56.39953. [20] AGUSTÍ A, CELLI B R, CRINER G J, et al. Global initiative for chronic obstructive lung disease 2023 report: GOLD executive summary[J]. Eur Respir J, 2023, 61(4): 2300239. DOI: 10.1183/13993003.00239-2023. [21] 陈小平, 李星, 何斐, 等. 基于物联网医疗下慢性阻塞性肺疾病规范化管理模式的SWOT分析[J]. 中国卫生标准管理, 2022, 13(13): 120-124.CHEN X P, LI X, HE P, et al. SWOT Analysis of the Standardized Management Model of Chronic Obstructive Pulmonary Disease Based on Internet of Things Medical Care[J]. China Health Standards Management, 2022, 13(13): 120-124. [22] 方慧, 施雁, 刘贤亮, 等. 医护人员对慢性阻塞性肺疾病患者开展居家肺康复阻滞因素及应对策略的质性研究[J]. 中国全科医学, 2021, 24(10): 1284-1288.FANG H, SHI Y, LIU X L, et al. Medical staff conducted a qualitative study on the obstructive factors and coping strategies of home-based pulmonary rehabilitation for patients with chronic obstructive pulmonary disease[J]. Chinese General Practice, 2021, 24(10): 1284-1288. -
点击查看大图
计量
- 文章访问数: 9
- HTML全文浏览量: 4
- PDF下载量: 2
- 被引次数: 0
下载: