基于免疫系统探讨酒精对骨质疏松症的作用机制

岳云祥; 任洋洋; 王刚; 康伯源; 徐西林

doi:10.16766/j.cnki.issn.1674-4152.004097

基于免疫系统探讨酒精对骨质疏松症的作用机制

doi: 10.16766/j.cnki.issn.1674-4152.004097

1.
黑龙江中医药大学研究生院，黑龙江哈尔滨 150040
2.
黑龙江中医药大学附属第三医院骨一科，黑龙江哈尔滨 150030

基金项目:

国家自然科学基金项目 8237153419

国家中医药管理局青年岐黄学者支持项目国中医药人教发〔2020〕7号

黑龙江省重点研发计划项目 GZ20210136

黑龙江省中医药科研项目 ZHY2023-099

详细信息

通讯作者:
徐西林，E-mail: eastoph@sina.com

中图分类号: R68 R392
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出版历程
- 收稿日期: 2024-10-29
- 网络出版日期: 2025-10-25

Exploring the mechanism of alcohol's effect on osteoporosis based on the immune system

1.
Graduate School of Heilongjiang University of Chinese Medicine, Harbin, Heilongjiang 150040, China

摘要

摘要: 骨质疏松症(osteoporosis, OP)是以骨强度下降以及骨折风险增加为特征的骨骼疾病，同时也是一种医学和社会经济威胁。酗酒行为在全球范围内普遍流行。由于特有的饮酒文化，我国酒精性疾病高发。长期酗酒可以通过直接影响成骨细胞、破骨细胞及其前体细胞，或通过间接影响蛋白质代谢、肝功能、内分泌等方式，导致骨代谢紊乱、骨量丢失及骨微观结构退化，进而引发骨质疏松症，但骨质疏松症的发病机制尚未完全阐明。免疫系统是一个由多种分子、细胞、组织和器官组成的复杂网络，也是维持人体生命的重要系统，旨在保护身体免受传染源和恶性细胞的侵害。近年来的研究表明，酒精与免疫系统有密切联系，特别是酒精对先天性免疫和适应性免疫的影响，以及免疫系统中许多免疫细胞如中性粒细胞、巨噬细胞、T细胞及B细胞与骨质疏松症的相关性。因此，本文从酒精对免疫系统的影响论述酒精对骨质疏松症的发病机制，旨在为骨质疏松症的机制研究、新药研发以及新的治疗策略提供思路和依据，并发现酒精通过干扰免疫细胞动态平衡(如抑制中性粒细胞、巨噬细胞、T和B淋巴细胞生成)及其相关信号通路活性(包括OPG/RANKL/RANK、JAK/STAT3、NF-κB及JNK通路)，同时异常调控促炎因子(如IL-1、IL-6、IL-17、TNF-α和IFN-γ)的分泌，直接或间接破坏骨形成与骨吸收的稳态平衡，最终导致骨质疏松症的发生。
- 骨质疏松症 /
- 酒精 /
- 免疫 /
- 先天性免疫 /
- 适应性免疫
Abstract: Osteoporosis (OP) is a skeletal disease characterized by a decrease in bone strength and an increased risk of fractures, posing both medical and socioeconomic threats. Alcohol abuse is prevalent worldwide, and due to unique drinking cultures, alcohol-related diseases are highly prevalent in our country. Long-term alcohol abuse can lead to bone metabolism disorders, bone loss, and degradation of bone microstructure by directly affecting osteoblasts, osteoclasts, and their precursor cells, or indirectly influencing protein metabolism, liver function, and endocrine systems, thereby triggering osteoporosis. However, the pathogenesis of osteoporosis has not yet been fully elucidated. The immune system is a complex network composed of various molecules, cells, tissues, and organs, and it is a crucial system for maintaining human life, aimed at protecting the body from infections and malignant cells. Recent studies have shown a close relationship between alcohol and the immune system, particularly the effects of alcohol on innate and adaptive immunity, as well as the correlation of many immune cells, such as neutrophils, macrophages, T cells, and B cells, with osteoporosis. Therefore, this article discusses the impact of alcohol on the immune system to elucidate the pathogenesis of osteoporosis, aiming to provide new insights and evidence for the mechanistic research of osteoporosis, the development of new drugs, and new treatment strategies. It also finds that alcohol disrupts the dynamic balance of immune cells (such as inhibiting the generation of neutrophils, macrophages, T and B lymphocytes) and the activity of related signaling pathways (including OPG/RANKL/RANK, JAK/STAT3, NF-κB, and JNK signaling pathways), while abnormally regulating the secretion of pro-inflammatory factors (such as IL-1, IL-6, IL-17, TNF-α, and IFN-γ), thereby directly or indirectly disrupting the homeostatic balance between bone formation and resorption, ultimately leading to the occurrence of osteoporosis.
- Osteoporosis /
- Alcohol /
- Immunity /
- Innate immunity /
- Adaptive immunity

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参考文献(36)

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