肝内脂肪对不同T<sub>1</sub> mapping方法评估肝纤维化的影响分析

谭恺; 汪国余; 吴玉林; 杨小萍; 徐祖良; 刘洪宇

doi:10.16766/j.cnki.issn.1674-4152.004096

肝内脂肪对不同T₁ mapping方法评估肝纤维化的影响分析

doi: 10.16766/j.cnki.issn.1674-4152.004096

台州市中心医院(台州学院附属医院)放射科，浙江台州 318000

基金项目:

浙江省医药卫生科技计划项目 2023KY1341

详细信息

通讯作者:
谭恺，E-mail：13857665156@163.com

中图分类号: R575.2 R445.2
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出版历程
- 收稿日期: 2024-10-15
- 网络出版日期: 2025-10-25

Influence of intrahepatic fat on the evaluation of hepatic fibrosis using different T₁ mapping techniques

Department of Radiology, Taizhou Central Hospital (Affiliated Hospital of Taizhou University), Taizhou, Zhejiang 318000, China

摘要

摘要: 目的通过不同磁共振T₁映射(T₁ mapping)方法探讨肝内脂肪对肝纤维化评估的影响。方法选取2021年2月—2024年2月于台州市中心医院接受治疗的140例非酒精性脂肪性肝病(NAFLD)患者作为研究对象，收集患者的质子密度脂肪分数以及不同T₁ mapping方法测量的肝脏T₁值，采用Pearson相关性分析研究T₁值与肝脏脂肪测量值间的关系。结果反相位(OP)图像上肝实质的T₁值显著高于同相位(IP)图像和压脂图(Water)图像上肝实质的T₁值，而Water图像上肝实质的T₁值高于IP图像上肝实质的T₁值(P < 0.05)；OP图像上肝实质的T₁值与质子密度脂肪分数(PDFF)呈弱正相关关系(r=0.219，P=0.015)，IP图像上肝实质的T₁值与PDFF呈负相关关系(r=-0.499，P < 0.001)，Water图像上肝实质的T₁值与PDFF不具有相关性(r=-0.138，P=0.130)，同时OP图像和IP图像上与Water图像上肝实质的T₁值差值绝对值与PDFF也具有相关性(r=0.373，P < 0.001；r=-0.258，P=0.004)。结论通过Dixon水脂分离成像技术获得的T₁ mapping Water序列图像受肝内脂肪的影响最小，最大化校正了肝内脂肪对肝脏T₁值的影响。
- 非酒精性脂肪性肝病 /
- 定量磁共振成像 /
- 肝纤维化 /
- T₁映射 /
- 质子密度脂肪分数
Abstract: Objective To explore the influence of intrahepatic fat on the assessment of hepatic fibrosis by different magnetic resonance T₁ mapping methods. Methods A total of 140 patients with nonalcoholic fatty liver disease (NAFLD) treated at Taizhou Central Hospital from February 2021 to February 2024 were selected as the research objects. The proton density fat fraction of patients and liver T₁ values obtained using different T₁ mapping methods were collected. The relationship between T₁ values and liver fat content was analyzed by Pearson correlation. Results T₁ value of liver parenchyma on OP image was significantly higher than that on IP image and Water image, while the T₁ value on Water image was higher than that on IP image (P < 0.05). The T₁ value of liver parenchyma was weakly positively correlated with the proton density fat fraction (PDFF) in OP image (r=0.219, P=0.015), and negatively correlated with PDFF in IP image (r=-0. 499, P < 0.001). There is no correlation between the T₁ value of liver parenchyma on Water image and PDFF (r=-0.138, P=0.130), while the absolute value of T₁ value difference between OP image and IP image is also correlated with PDFF (r=0.373, P < 0.001; r=-0.258, P=0.004). Conclusion T₁ mapping water sequence images obtained using Dixon water-fat separation imaging technology are minimally affected by hepatic fat, providing the most effective correction for fat-related interference in liver T₁ measurements.
- Nonalcoholic fatty liver disease /
- Quantitative magnetic resonance imaging /
- Hepatic fibrosis /
- T₁ mapping /
- Proton density fat fraction

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表 1 NAFLD患者不同T₁ mapping方法T₁值和PDFF

Table 1. T₁ values and PDFF using various T₁ mapping methods in NAFLD patients

项目	数值(x±s)	范围
T₁-IP(ms)	614.67±23.59	563.76~679.01
T₁-OP(ms)	688.04±33.86	648.40~749.73
T₁-Water(ms)	633.67±30.42	591.04~708.35
PDFF(%)	4.36±1.28	2.26~6.33
T₁-(Water/IP)	20.77±6.45	10.15~29.34
T₁-(Water/OP)	-52.95±12.69	-57.36~-4.30
注：T₁-IP为同相位T₁ mapping序列的T₁值；T₁-OP为反相位T₁ mapping序列的T₁值；T₁-Water为压脂图T₁ mapping序列的T₁值；T₁-(Water/IP)为T₁-Water和T₁-IP的差值；T₁-(Water/OP)为T₁-Water和T₁-OP的差值。

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