失眠过度觉醒状态的中西医研究进展

傅晗昕; 张芯; 胡霖霖

doi:10.16766/j.cnki.issn.1674-4152.004073

失眠过度觉醒状态的中西医研究进展

doi: 10.16766/j.cnki.issn.1674-4152.004073

1.
浙江中医药大学附属杭州市中医院睡眠医学中心，浙江杭州 310007
2.
浙江中医药大学药学院，浙江杭州 310053

基金项目:

国家自然科学基金项目 82205000

浙江省中医药(中西医结合)重点学科建设计划项目 2024-XK-59

详细信息

通讯作者:
胡霖霖，E-mail：hulinlin1028@126.com

中图分类号: R749.7 R256.23
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- 文章访问数: 8
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- 被引次数: 0
出版历程
- 收稿日期: 2024-04-17
- 网络出版日期: 2025-10-25

Research progress in traditional Chinese and western medicine on hyperarousal in insomnia disorder

FU Hanxin¹,
ZHANG Xin²,
HU Linlin^{1
, ,}

1.
Sleep Medicine Center of Hangzhou TCM Hospital Affiliated to Zhejiang Chinese Medical University, Hangzhou, Zhejiang 310007, China

摘要

摘要: 失眠障碍是最常见的睡眠-觉醒障碍，过度觉醒则被广泛认为是失眠障碍的核心特征，在其发生和维持过程中起着关键作用。因此，本文总结了过度觉醒的概念及其与失眠的关系，涵盖失眠过度觉醒的机制假说、临床特征和中西医治疗的研究进展。在过度觉醒的概念中，概述了过度觉醒的定义及其在皮层、生理和认知层面的表现与检测方法。针对失眠过度觉醒的机制假说，总结多种机制模型，这些模型均在不同程度上强调了过度觉醒是失眠发生发展的关键因素。在失眠过度觉醒状态的临床特征部分，既往研究发现失眠患者在自主神经活动、神经内分泌、神经免疫、神经电生理和神经影像学等多方面均存在过度觉醒现象。此外，中西医各自的治疗方法也多与降低过度觉醒水平密切相关。今后，临床治疗和药理作用机制研究应更加关注失眠患者的过度觉醒问题，进一步探索更有效的治疗方法，以改善失眠患者的睡眠质量。
- 失眠障碍 /
- 过度觉醒 /
- 研究进展
Abstract: Insomnia disorder is the most prevalent type of sleep-wake disorder. Recent research on the etiology and pathogenesis has increasingly emphasized hyperarousal, which is now recognized as a core feature. Thus, this article summarizes the concept of the hyperarousal and its relationship with insomnia disorder, including hypothesis regarding its relationship with insomnia disorders, the clinical features of hyperarousal, and recent advances in both traditional Chinese and western medical treatment. Firstly, this article outlines the definition of hyperarousal, along with its main manifestations and detection methods of hyperarousal at the cortical, physiological, and cognitive levels. Secondly, this article introduces several hypotheses and models of insomnia disorders, all of which highlight hyperarousal as an important factor in the occurrence and progression of insomnia. In addition, previous studies have demonstrated that individuals with insomnia exhibit hyperarousal across multiple domains, including autonomic nervous activity, neuroendocrine, neuroimmune, neuroelectrophysiology, and neuroimaging. Finally, both traditional Chinese and western medical treatments have been shown to act on mechanisms involved in reducing the level of hyperarousal. Future clinical treatment and pharmacological research should place increased emphasis on addressing hyperarousal, aiming to explore more effective therapeutic methods to reduce its impact and enhance the quality of sleeping.
- Hyperarousal /
- Insomnia /
- Research progress

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