经颅超声刺激联合不同强度电刺激对中老年睡眠障碍患者的疗效观察

郭迦期; 李舒; 党瑞雪; 韩颖; 高静媛

doi:10.16766/j.cnki.issn.1674-4152.004072

经颅超声刺激联合不同强度电刺激对中老年睡眠障碍患者的疗效观察

doi: 10.16766/j.cnki.issn.1674-4152.004072

1.
华北理工大学附属医院全科医学科，河北唐山 063000
2.
华北理工大学临床医学系，河北唐山 063000

基金项目:

河北省卫生健康委医学科学研究课题项目 20240760

详细信息

通讯作者:
高静媛，E-mail：gaojingyuan2009@126.com

中图分类号: R493 R741.05
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- 文章访问数: 15
- HTML全文浏览量: 12
- PDF下载量: 1
- 被引次数: 0
出版历程
- 收稿日期: 2024-04-11
- 网络出版日期: 2025-10-25

Effect of transcranial ultrasound stimulation combined with electrical stimulation of different intensity on middle-aged and elderly patients with sleep disorders

1.
Department of General Practice, North China University of Science and Technology Affiliation Hospital, Tangshan, Hebei 063000, China

摘要

摘要: 目的为改善中老年人睡眠障碍，采用经颅超声刺激(TUS)联合不同强度电刺激治疗方案，探讨2种物理技术联合治疗的效果。方法选取2021年11月—2024年2月在华北理工大学附属医院住院的150例中老年睡眠障碍患者为研究对象。按入院时间分为高强度组、低强度组和对照组，每组各50例。各组在给予相同经颅超声刺激基础上，增加不同强度电刺激，连续治疗2周。比较3组治疗后匹兹堡睡眠质量指数量表(PSQI)总分、睡眠时间、睡眠效率、PSQI减分率、血清皮质醇(CORT)及不良反应。结果治疗后，高强度组[80.00(71.00, 88.00)%]和低强度组[75.00(70.00, 80.00)%]的睡眠效率均优于对照组[71.00(63.75, 78.50)%, P＜0.05]；治疗后，高强度组[(6.52±1.39)分]和低强度组[(8.60±1.43)分]PSQI总评分均优于对照组[(9.74±2.43)分, P＜0.05]。低强度组[(37.65±9.28)%]和高强度组[(52.51±9.36)%]的PSQI减分率优于对照组[(31.19±12.26)%, P＜0.05]。治疗后，高强度组[(10.28±2.21)μg/dL]和低强度组[(12.66±2.85)μg/dL]的CORT水平均优于对照组[(15.18±2.78)μg/dL, P＜0.05]。治疗期间，3组不良反应发生率比较差异无统计学意义(P＞0.05)。结论经颅超声刺激联合电刺激能改善患者睡眠障碍功能，且电刺激强度与疗效呈正比。经颅超声刺激联合电刺激对减低患者CORT水平效果优于单独经颅超声刺激。
- 睡眠障碍 /
- 中老年人 /
- 经颅超声刺激 /
- 电刺激 /
- 睡眠质量
Abstract: Objective To improve sleep disorders in middle-aged and elderly people, this study adopted a treatment plan of transcranial ultrasound stimulation (TUS) combined with different intensities of electrical stimulation and explores the therapeutic effect of the combination of two physical methods. Methods The research selected 150 middle-aged and elderly patients with sleep disorders who were treated in the Affiliated Hospital of North China University of Science and Technology from November 2021 to February 2024 as the research targets. According to the admission time, the patients were divided into high-intensity group, low-intensity group and control group, with 50 cases in each group. On the basis of the same transcranial ultrasound stimulation, the patients in each group were given different intensities of electrical stimulation, and the treatment lasted for 2 weeks. Compare the scores of the Pittsburgh sleep quality index (PSQI), sleep time, sleep efficiency, PSQI reduction rate, serum cortisol (CORT), and adverse reactions among three groups after treatment. Results After treatment, the sleep efficiency of the high-intensity group [80.00 (71.00, 88.00) %] and the low-intensity group [75.00 (70.00, 80.00) %] was better than that of the control group [71.00 (63.75, 78.50) %, P < 0.05]; After treatment, the total PSQI scores of the high-intensity group (6.52±1.39) and the low-intensity group (8.60±1.43) were better than those of the control group (9.74±2.43, P < 0.05). The PSQI reduction rates in the low-intensity group [(37.65±9.28) %] and the high-intensity group [(52.51±9.36) %] were higher than those in the control group [(31.19±12.26) %, P < 0.05]. After treatment, the CORT levels in the high-intensity group [(10.28±2.21) μg/dL] and the low-intensity group [(12.66±2.85) μg/dL] were both better than those in the control group [(15.18±2.78) μg/dL, P < 0.05]. During the treatment period, there was no statistically significant difference in the incidence of adverse reactions among the three groups (P>0.05). Conclusion Transcranial ultrasound stimulation combined with electrical stimulation can improve sleep disorders in patients, and the intensity of electrical stimulation is directly proportional to the therapeutic effect. The combination of transcranial ultrasound stimulation and electrical stimulation is more effective in reducing CORT levels in patients than transcranial ultrasound stimulation alone.
- Sleep disorder /
- Middle aged and elderly people /
- Transcranial ultrasound stimulation /
- Electrical stimulation /
- Sleep quality

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表 1 3组中老年睡眠障碍患者一般临床资料比较

Table 1. Comparison of general clinical data among three groups of middle-aged and elderly patients with sleep disorders

组别	例数	性别[例(%)]		年龄 (x±s, 岁)	病程 [M(P₂₅, P₇₅), 年]	职业[例(%)]
组别	例数	男性	女性	年龄 (x±s, 岁)	病程 [M(P₂₅, P₇₅), 年]	体力劳动	脑力劳动
对照组	50	24(48.00)	26(52.00)	60.88±11.04	6.00(4.00，7.00)	21(42.00)	29(58.00)
低强度组	50	23(46.00)	27(54.00)	61.44±12.06	5.50(3.00, 7.00)	18(36.00)	32(64.00)
高强度组	50	20(40.00)	30(60.00)	61.18±12.11	5.00(2.75, 7.00)	24(48.00)	26(52.00)
统计量		0.701^a		0.028^b	2.183^c	1.478^a
P值		0.704		0.972	0.336	0.478
注：^a为χ²值，^b为F值，^c为H值。

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表 2 3组中老年睡眠障碍患者治疗前后睡眠相关指标比较

Table 2. Comparison of sleep related indicators among three groups of middle-aged and elderly patients with sleep disorders

组别	例数	睡眠时间(x±s, h)		睡眠效率[M(P₂₅, P₇₅)，%]		PSQI总评分(x±s, 分)
组别	例数	治疗前	治疗后	治疗前	治疗后	治疗前	治疗后
高强度组	50	5.33±0.84	6.78±0.76^b	65.50(60.00, 73.50)	80.00(71.00, 88.00)^bd	13.80±1.67	6.52±1.39^bd
低强度组	50	5.19±0.76	6.55±0.73^b	67.00(62.00, 73.25)	75.00(70.00, 80.00)^b	13.88±1.93	8.60±1.43^b
对照组	50	5.28±0.74	6.10±1.08	64.50(60.00, 71.00)	71.00(63.75, 78.50)	14.12±2.45	9.74±2.43
统计量		0.415^a	7.849^a	1.593^c	20.921^c	0.332^a	40.473^a
P值		0.661	＜0.001	0.451	＜0.001	0.718	＜0.001
注：^a为F值，^c为H值。与对照组比较，^bP＜0.05；与低强度组比较，^dP＜0.05。

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表 3 3组中老年睡眠障碍患者治疗前后睡眠相关指标差值比较

Table 3. Comparison of sleep-related indicators before and after treatment among three groups of middle-aged and elderly patients with sleep disorders

组别	例数	睡眠时间差值[M(P₂₅, P₇₅), h]	睡眠效率差值[M(P₂₅, P₇₅), %]	PSQI总评分差值(x±s, 分)
高强度组	50	1.75(1.00，2.00)^a	13.00(7.00, 18.25)^ac	7.26±1.73^ac
低强度组	50	2.00(1.50，2.00)^a	7.00(1.00, 14.00)	5.28±1.69^a
对照组	50	1.00(1.00，2.00)	4.00(0.00, 12.00)	4.36±1.72
统计量		15.964^b	18.487^b	37.148^d
P值		＜0.001	＜0.001	＜0.001
注：与对照组比较，^aP＜0.05；与低强度组比较，^cP＜0.05。^b为H值，^d为F值。

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表 4 3组中老年睡眠障碍患者PSQI减分率比较(x ±s, %)

Table 4. Comparison of PSQI reduction rates among three groups of middle-aged and elderly patients with sleep disorders (x ±s, %)

组别	例数	PSQI减分率
对照组	50	31.19±12.26
低强度组	50	37.65±9.28^a
高强度组	50	52.51±9.36^ab
F值		55.304
P值		＜0.001
注：与对照组比较，^aP＜0.05；与低强度组比较，^bP＜0.05。

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表 5 3组中老年睡眠障碍患者血清皮质醇水平比较(x ±s, μg/dL)

Table 5. Comparison of serum cortisol levels among three groups of middle-aged and elderly patients with sleep disorders (x ±s, μg/dL)

组别	例数	治疗前	治疗后	治疗前后差值
高强度组	50	18.20±3.31	10.28±2.21^abc	7.92±2.99^bc
低强度组	50	17.80±3.73	12.66±2.85^ab	5.14±2.92^b
对照组	50	18.40±3.72	15.18±2.78^a	3.22±1.82
F值		0.362	43.492	40.307
P值		0.697	＜0.001	＜0.001
注：与治疗前比较，^aP＜0.05；与对照组比较，^bP＜0.05；与低强度组比较，^cP＜0.05。

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