自拟补肾养肝汤加减联合定坤丹用于卵巢早衰患者的临床研究

何菊; 沈丹

doi:10.16766/j.cnki.issn.1674-4152.004017

自拟补肾养肝汤加减联合定坤丹用于卵巢早衰患者的临床研究

doi: 10.16766/j.cnki.issn.1674-4152.004017

何菊¹,
沈丹^2, ,

1.
绍兴市中医院妇科，浙江绍兴 312000
2.
杭州市中医院妇科，浙江杭州 310000

基金项目:

浙江省中医药科技计划项目 2022ZB234

详细信息

通讯作者:
沈丹，E-mail：65871865@163.com

中图分类号: R711.75 R289.5
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- 文章访问数: 8
- HTML全文浏览量: 5
- PDF下载量: 0
- 被引次数: 0
出版历程
- 收稿日期: 2024-07-23
- 网络出版日期: 2025-08-14

Clinical study on self-made Bushen Yanggan Decoction combined with Dingkundan in the treatment of premature ovarian failure

HE Ju¹,
SHEN Dan^{2
, ,}

1.
Department of Gynecology, Shaoxing Hospital of Traditional Chinese Medicine, Shaoxing, Zhejiang 312000, China

摘要

摘要: 目的探讨自拟补肾养肝汤加减联合定坤丹对卵巢早衰患者性激素、糖脂代谢水平变化的影响，并分析其在提高患者生活质量方面的作用。方法根据采取的治疗方案将2022年6月—2024年3月于绍兴市中医院接受治疗的97例卵巢早衰患者分为西医组(48例)和中医组(49例)，西医组给予西医激素治疗，中医组给予口服定坤丹联合自拟补肾养肝汤加减治疗。比较2组患者治疗后的中医证候疗效、性激素、糖脂代谢水平变化、生活质量等。结果中医组的治疗总有效率高于西医组[91.84%(45/49) vs. 75.00%(36/48), χ²=4.990，P=0.025]；中医组的HbA1c[(4.84±0.80)% vs.(5.18±0.73)%，P < 0.05]等糖脂代谢指标水平均低于西医组；中医组促黄体生成素/卵泡刺激素值(1.93±0.65 vs. 3.00±0.91)低于西医组(P＜0.001)；中医组的生活质量得分在治疗4周[(69.22±7.21)分vs. (64.29±8.02)分]、8周[(80.29±8.63)分vs.(70.63±6.34)分]、12周[(86.39±4.15)分vs. (72.33±4.38)分]后均高于西医组(P＜0.05)。结论自拟补肾养肝汤加减联合定坤丹在改善卵巢早衰患者性激素、糖脂代谢水平以及生活质量方面存在明显、持续性的益处，且安全性较高，值得在临床推广。
- 卵巢早衰 /
- 定坤丹 /
- 补肾养肝汤加减 /
- 生活质量 /
- 糖脂代谢 /
- 性激素
Abstract: Objective To explore the effect of self-made Bushen Yanggan Decoction combined with Dingkundan on the changes of sex hormones and glucose and lipid metabolism in patients with premature ovarian insufficiency, and analyze its role in improving the quality of life of patients. Methods A total of 97 cases of premature ovarian insufficiency treated in Shaoxing Hospital of Traditional Chinese Medicine from June 2022 to March 2024 were selected as the research object, and divided into western medicine (WM) group (48 cases) and traditional Chinese medicine (TCM) group (49 cases) according to the treatment regimen taken. The WM group received hormone therapy from western medicine, while the TCM group was treated with Dingkundan combined with self-made Bushen Yanggan Decoction. The curative effect of TCM syndrome, changes of sex hormones, glucose and lipid metabolism level and quality of life were compared between the two groups after treatment. Results The total effective rate of TCM group was higher than that of WM group [91.84% (45/49) vs. 75.00% (36/48), χ²=4.990, P=0.025]. HbA1c [(4.84±0.80)% vs. (5.18±0.73)%, P < 0.05] and other glucose and lipid metabolism levels in TCM group were lower than those in WM group. The luteinizing hormone/follicular stimulating hormone ratio of TCM group (1.93±0.65 vs. 3.00±0.91) was lower than that of WM group (P < 0.001). The quality of life scores in TCM group were significantly higher than those in WM group at 4 weeks [(69.22±7.21) points vs. (64.29±8.02) points], 8 weeks [(80.29±8.63) points vs. (70.63±6.34) points], and 12 weeks [(86.39±4.15) points vs. (72.33±4.38) points] after treatment (P < 0.05). Conclusion Self-made Bushen Yanggan Decoction combined with Dingkundan has obvious and sustained benefits in improving sex hormones, glucose and lipid metabolism and quality of life in patients with premature ovarian failure, and it is safe and worthy of clinical promotion.
- Premature ovarian insufficiency /
- Dingkundan /
- Bushen Yanggan Decoction /
- Quality of life /
- Glycolipid metabolism /
- Sex hormone

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表 1 2组卵巢早衰患者中医证候疗效比较[例(%)]

Table 1. Comparison of TCM syndrome curative effect between two groups of patients with premature ovarian failure[cases(%)

组别	例数	治愈	显效	有效	无效	总有效
西医组	48	5(10.42)	17(35.42)	14(29.17)	12(25.00)	36(75.00)
中医组	49	12(24.49)	20(40.82)	13(26.53)	4(8.16)	45(91.84)
注：2组总有效率比较，χ²=4.990，P=0.025。

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表 2 2组卵巢早衰患者糖脂代谢水平比较(x±s)

Table 2. Comparison of glucose and lipid metabolism between two groups of patients with premature ovarian failure(x±s)

组别	例数	HbA1c(%)		FINS(U/L)		TC(mmol/L)		TG(mmol/L)
组别	例数	治疗前	12周后	治疗前	12周后	治疗前	12周后	治疗前	12周后
西医组	48	5.91±1.05	5.18±0.73^b	18.49±3.19	13.38±2.53^b	5.37±0.95	4.42±0.87^b	3.05±0.43	2.24±0.41^b
中医组	49	5.82±1.11	4.84±0.80^b	18.72±4.03	9.53±1.84^b	5.50±1.01	3.77±0.79^b	3.14±0.39	1.76±0.61^b
统计量		0.410^a	8.970^c	0.312^a	64.341^c	0.653^a	23.570^c	1.079^a	19.272^c
P值		0.683	0.004	0.756	< 0.001	0.515	< 0.001	0.283	< 0.001
注：^a为t值, ^c为F值; 与同组治疗前比较, ^bP < 0.05。

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表 3 2组卵巢早衰患者性激素水平比较(x±s)

Table 3. Comparison of sex hormone levels between two groups of patients with premature ovarian failure(x±s)

组别	例数	E2(pg/mL)		AMH(μg/L)		LH/FSH
组别	例数	治疗前	12周后	治疗前	12周后	治疗前	12周后
西医组	48	78.64±4.82	68.47±3.95^b	0.13±0.04	0.61±0.12^b	4.03±1.14	3.00±0.91^b
中医组	49	77.48±5.23	60.22±4.23^b	0.12±0.03	1.05±0.21^b	3.95±0.88	1.93±0.65^b
统计量		1.136^a	118.912^c	1.391^a	174.367^c	0.386^a	32.379^c
P值		0.259	< 0.001	0.168	< 0.001	0.700	< 0.001
注: ^a为t值, ^c为F值; 与同组治疗前比较, ^bP < 0.05。

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表 4 2组卵巢早衰患者生活质量评分比较(x±s，分)

Table 4. Comparison of quality of life between two groups of patients with premature ovarian failure(x±s, points)

组别	例数	治疗前	4周后	8周后	12周后
西医组	48	60.12±4.15	64.29±8.02^a	70.63±6.34^a	72.33±4.38^a
中医组	49	59.48±5.26	69.22±7.21^a	80.29±8.63^a	86.39±4.15^a
F值		0.666	7.000	12.836	96.384
P值		0.507	0.010	0.001	＜0.001
注：与同组治疗前比较，^aP < 0.05。

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