线粒体-炎症小体通路在慢性肝脏疾病中的作用

吴欢; 伍龙; 张宝芳

doi:10.16766/j.cnki.issn.1674-4152.003972

线粒体-炎症小体通路在慢性肝脏疾病中的作用

doi: 10.16766/j.cnki.issn.1674-4152.003972

吴欢¹,
伍龙²,
张宝芳^1, ,

1.
贵州医科大学附属医院感染科，贵州贵阳 550004
2.
贵州医科大学附属医院肛肠外科

基金项目:

2024年度贵州省卫生健康委员会科技基金项目 gzwkj2024-10

贵州省科技计划项目黔科合基础-ZK[2024]一般210

2023年度贵州省卫生健康委员会科技基金项目 gzwkj2023-042

详细信息

通讯作者:
张宝芳，E-mail：zhangbaofang@gmc.edu.cn

中图分类号: R575.2
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出版历程
- 收稿日期: 2024-03-21
- 网络出版日期: 2025-06-30

The role of the mitochondria-inflammasome pathway in the progression of chronic liver disease

WU Huan¹,
WU Long²,
ZHANG Baofang^{1
, ,}

1.
Department of Infectious Diseases, the Affiliated Hospital of Guizhou Medical University, Guiyang, Guizhou 550004, China

摘要

摘要: 慢性肝脏疾病(chronic liver disease，CLD)是全球范围内一个严重的健康问题，其发病率和致死率不断上升。在慢性肝脏疾病的进展中，线粒体功能障碍和炎症小体通路的激活起着关键作用。线粒体作为细胞的能量中心，不仅参与能量代谢，还在细胞凋亡、氧化应激和炎症等重要过程中发挥重要作用。而炎症小体则是一种细胞内多蛋白质复合物，对细胞应对病原体和细胞应激反应起着关键作用。目前，越来越多的研究将线粒体与炎症小体相结合，发现线粒体在炎症小体激活中具有重要作用。受损的线粒体可以释放出一些信号分子，这些分子可以促使炎症小体的形成和激活，促进白细胞介素-1β(IL-1β)、白细胞介素-18(IL-18)、肿瘤坏死因子α(TNF-α)等炎症因子的释放，线粒体相关的蛋白质也可以直接参与炎症小体的组装和激活过程。关于线粒体和炎症小体在慢性肝脏疾病中的关系，目前的研究取得了一些进展。本文旨在阐述线粒体和炎症小体的结构、激活信号及通路、调节机制，以及它们与慢性肝脏疾病之间关系的研究进展，以期为慢性肝脏疾病的治疗提供新的方向和靶点。
- 线粒体 /
- 炎症小体 /
- 慢性肝脏疾病
Abstract: Chronic liver disease is a serious global health concern, with increasing incidence and mortality rates. Mitochondrial dysfunction and activation of the inflammasome pathway play key roles in the progression of chronic liver disease. As the energy center of cells, mitochondria are involved not only in energy metabolism but also in apoptosis, oxidative stress, and inflammation. The inflammasome, an intracellular multiprotein complex, is essential for the cell' s response to pathogens and cellular stress. Recent studies have increasingly linked mitochondria and inflammasome activation, revealing that mitochondria play an important role in inflammasome activation. Damaged mitochondria release signaling molecules that promote the formation and activation of inflammasome, triggering the release of inflammatory cytokines such as IL-1β, IL-18, and TNF-α. Additionally, mitochondria-related proteins directly participate in the assembly and activation of inflammasome. Current researches have shed light on the relationship between mitochondria and inflammasomes in chronic liver disease. In this review, we aim to elaborate on the structure, activation signal pathways, regulatory mechanisms, and their relationship with chronic liver diseases. These insights may offer new directions and targets for the treatment of chronic liver diseases.
- Mitochondria /
- Inflammasome /
- Chronic liver disease

HTML全文

图 1 慢性肝损伤过程中线粒体调控炎症小体激活的机制

Figure 1. The mechanism of mitochondrial regulation of inflammasome activation during chronic liver injury

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