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外周血NF-κB、IL-6、IL-10、IFN-α、T细胞亚群计数水平在预测AECOPD患者预后中的临床价值

李毅 倪为波 池毅 商焕霞 郭立娟

李毅, 倪为波, 池毅, 商焕霞, 郭立娟. 外周血NF-κB、IL-6、IL-10、IFN-α、T细胞亚群计数水平在预测AECOPD患者预后中的临床价值[J]. 中华全科医学, 2025, 23(4): 588-591. doi: 10.16766/j.cnki.issn.1674-4152.003957
引用本文: 李毅, 倪为波, 池毅, 商焕霞, 郭立娟. 外周血NF-κB、IL-6、IL-10、IFN-α、T细胞亚群计数水平在预测AECOPD患者预后中的临床价值[J]. 中华全科医学, 2025, 23(4): 588-591. doi: 10.16766/j.cnki.issn.1674-4152.003957
LI Yi, NI Weibo, CHI Yi, SHANG Huanxia, GUO Lijuan. The clinical value of NF-κB, IL-6, IL-10, IFN-α and T cell subsets in peripheral blood in predicting the prognosis of AECOPD patients[J]. Chinese Journal of General Practice, 2025, 23(4): 588-591. doi: 10.16766/j.cnki.issn.1674-4152.003957
Citation: LI Yi, NI Weibo, CHI Yi, SHANG Huanxia, GUO Lijuan. The clinical value of NF-κB, IL-6, IL-10, IFN-α and T cell subsets in peripheral blood in predicting the prognosis of AECOPD patients[J]. Chinese Journal of General Practice, 2025, 23(4): 588-591. doi: 10.16766/j.cnki.issn.1674-4152.003957

外周血NF-κB、IL-6、IL-10、IFN-α、T细胞亚群计数水平在预测AECOPD患者预后中的临床价值

doi: 10.16766/j.cnki.issn.1674-4152.003957
基金项目: 

河北省医学科学研究课题计划 20242171

详细信息
    通讯作者:

    郭立娟,E-mail:guolijuan185548@163.com

  • 中图分类号: R563

The clinical value of NF-κB, IL-6, IL-10, IFN-α and T cell subsets in peripheral blood in predicting the prognosis of AECOPD patients

  • 摘要:   目的  探究外周血核转录因子κB(NF-κB)、白介素-6(IL-6)、白介素10(IL-10)、干扰素α(IFN-α)、T细胞亚群计数水平在预测慢性阻塞性肺疾病急性加重期(AECOPD)患者预后中的临床价值,以期为该病临床治疗提供参考。  方法  选取2023年6月—2024年3月河北省胸科医院收治的204例AECOPD患者为研究对象,根据6个月预后情况分为预后不良组(67例)与预后良好组(137例)。比较2组外周血NF-κB、IL-6、IL-10、IFN-α、T细胞亚群计数水平,并分析上述指标对患者预后的预测价值。  结果  预后不良组外周血NF-κB、IL-6、IL-10、IFN-α水平及CD8+高于预后良好组,CD3+、CD4+、CD4+/CD8+低于预后良好组(P<0.05)。Logistic回归分析结果显示,外周血NF-κB、IL-6、IL-10、IFN-α、CD3+、CD4+、CD8+、CD4+/CD8+均为影响AECOPD患者预后的相关因素(P<0.05)。受试者工作特征曲线显示,外周血NF-κB、IL-6、IL-10、IFN-α、CD3+、CD4+、CD8+、CD4+/CD8+预测AECOPD患者预后的曲线下面积分别为0.804、0.806、0.858、0.842、0.626、0.702、0.724、0.854。  结论  外周血NF-κB、IL-6、IL-10、IFN-α、T细胞亚群计数水平与AECOPD患者预后密切相关,可作为预测AECOPD患者预后的重要指标,具有一定的临床价值。

     

  • 图  1  外周血NF-κB、IL-6、IL-10、IFN-α、T细胞亚群计数预测AECOPD患者预后的ROC曲线

    Figure  1.  ROC curve of NF-κB, IL-6, IL-10, IFN-α, and T cell subsets in peripheral blood for predicting prognosis in AECOPD patients

    表  1  2组AECOPD患者一般资料比较

    Table  1.   Comparison of general information between two patient groups with AECOPD

    项目 预后不良组(n=67) 预后良好组(n=137) 统计量 P
    性别[例(%)] 0.885a 0.347
      男性 40(59.70) 91(66.42)
      女性 27(40.30) 46(33.58)
    年龄(x±s,岁) 58.36±5.14 57.75±5.39 0.771b 0.442
    BMI(x±s) 21.93±1.03 22.01±1.15 0.482b 0.630
    吸烟史[例(%)] 1.289a 0.256
      有 35(52.24) 60(43.80)
      无 32(47.76) 77(56.20)
    饮酒史[例(%)] 0.471a 0.493
      有 16(23.88) 27(19.71)
      无 51(76.12) 110(80.29)
    糖尿病[例(%)] 0.535a 0.465
      有 31(46.27) 56(40.88)
      无 36(53.73) 81(59.12)
    高血压[例(%)] 1.807a 0.179
      有 30(44.78) 48(35.04)
      无 37(55.22) 89(64.96)
    COPD病程(x±s,年) 11.25±2.01 10.81±1.69 1.639b 0.103
    注:a为χ2值,bt值。
    下载: 导出CSV

    表  2  2组AECOPD患者外周血NF-κB、IL-6、IL-10、IFN-α水平比较(x±s)

    Table  2.   Comparison of NF-κB, IL-6, IL-10, and IFN-α in peripheral blood between two groups of AECOPD patients (x±s)

    组别 例数 NF-κB(μg/L) IL-6(pg/mL) IL-10(pg/mL) IFN-α(pg/mL)
    预后不良组 67 0.79±0.20 10.25±2.06 4.28±1.01 3.07±0.75
    预后良好组 137 0.61±0.14 8.04±1.12 2.80±0.55 2.11±0.42
    t 7.450 9.925 13.548 11.707
    P <0.001 <0.001 <0.001 <0.001
    下载: 导出CSV

    表  3  2组AECOPD患者T细胞亚群计数比较(x±s)

    Table  3.   Comparison of T cell subsets between two groups of AECOPD patient (x±s)

    组别 例数 CD3+(×107/L) CD4+(×107/L) CD8+(×107/L) CD4+/CD8+
    预后不良组 67 71.20±21.02 32.94±7.69 29.15±6.13 1.10±0.21
    预后良好组 137 84.73±24.29 38.86±9.41 24.90±4.92 1.45±0.28
    t 3.900 4.470 5.333 9.057
    P <0.001 <0.001 <0.001 <0.001
    下载: 导出CSV

    表  4  AECOPD患者预后影响因素的多因素分析

    Table  4.   Multivariate analysis of factors influencing prognosis in AECOPD patients

    变量 B SE Waldχ2 P OR 95% CI
    NF-κB 0.927 0.315 8.660 0.003 2.527 1.363~4.685
    IL-6 1.728 0.483 12.800 <0.001 5.629 2.184~14.508
    IL-10 1.386 0.391 12.565 <0.001 3.999 1.858~8.605
    IFN-α 0.759 0.261 8.457 0.004 2.136 1.281~3.563
    CD3+ -0.897 0.312 8.266 0.004 0.408 0.221~0.752
    CD4+ -0.597 0.211 8.005 0.005 0.550 0.364~0.832
    CD8+ 0.521 0.206 6.396 0.012 1.684 1.124~2.521
    CD4+/CD8+ -1.051 0.443 5.629 0.018 0.350 0.147~0.833
    注:所有变量均为连续变量,以实际值赋值。预后不良=1,预后良好=0。
    下载: 导出CSV

    表  5  外周血NF-κB、IL-6、IL-10、IFN-α、T细胞亚群计数对AECOPD患者预后的预测价值

    Table  5.   Prognostic value of NF-κB, IL-6, IL-10, IFN-α, and T cell subsets in peripheral blood of patients with AECOPD

    项目 截断值 灵敏度(%) 特异度(%) 约登指数 AUC 95% CI P
    NF-κB 0.66 μg/L 77.61 70.07 0.477 0.804 0.743~0.856 <0.001
    IL-6 9.33 pg/mL 67.16 89.05 0.562 0.806 0.745~0.858 <0.001
    IL-10 3.64 pg/mL 67.16 94.89 0.621 0.858 0.803~0.903 <0.001
    IFN-α 2.57 pg/mL 73.13 83.94 0.571 0.842 0.784~0.889 <0.001
    CD3+ 78.63×107/L 55.22 67.88 0.231 0.626 0.555~0.692 0.004
    CD4+ 37.64×107/L 79.10 54.74 0.339 0.702 0.634~0.764 <0.001
    CD8+ 28.24×107/L 41.79 94.16 0.360 0.724 0.657~0.784 <0.001
    CD4+/CD8+ 1.38 91.04 68.61 0.597 0.854 0.798~0.900 <0.001
    下载: 导出CSV
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  • 收稿日期:  2024-05-11
  • 网络出版日期:  2025-06-30

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