双气囊小肠镜治疗黑斑息肉综合征患者小肠息肉的临床分析

刁磊; 吴巧玲; 刘红; 卢建

doi:10.16766/j.cnki.issn.1674-4152.003954

双气囊小肠镜治疗黑斑息肉综合征患者小肠息肉的临床分析

doi: 10.16766/j.cnki.issn.1674-4152.003954

安徽医科大学第一附属医院消化内科，安徽合肥 230022

基金项目:

安徽省教育厅高校科研项目 2022AH051137

详细信息

通讯作者:
卢建，E-mail: ayfy_lujian@163.com

中图分类号: R574
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出版历程
- 收稿日期: 2024-07-24
- 网络出版日期: 2025-06-30

Clinical analysis of small bowel polyps in patients with Peutz-Jeghers syndrome treated with double balloon enteroscopy

Department of Gastroenterology, the First Affiliated Hospital of Anhui Medical University, Hefei, Anhui 230022, China

摘要

摘要: 目的探讨双气囊小肠镜(DBE)对黑斑息肉综合征(PJS)患者小肠息肉治疗的效果及安全性。方法回顾性分析2020年6月—2023年11月于安徽医科大学第一附属医院消化内科接受DBE治疗的PJS患者临床资料，统计患者小肠息肉切除成功率、术中及术后并发症发生情况。结果共纳入12例患者(男性7例，女性5例)，年龄为(29.94±13.29)岁。12例患者共进行20例次DBE检查及治疗(15例次经口进镜，5例次经肛进镜)。经口和经肛入镜的插管深度分别为(306.00±126.71)cm和(220.00±34.64)cm。12例患者息肉以空肠多见(100.0%)，其中伴有胃息肉2例(16.7%)，伴有结肠息肉2例(16.7%)。小肠息肉数目不等，大小不一，最大的息肉直径为5.0 cm，最小为0.3 cm。息肉切除成功率为100.0%，且无内镜下治疗相关严重并发症。5例患者有2次或2次以上住院治疗记录，第2次住院切除息肉的最大直径与第1次住院[(1.70±0.98)cm vs. (2.67±0.58)cm]比较，尽管差异无统计学意义(t=1.467，P=0.216)，但相较于第1次住院息肉直径有缩小的趋势。随访结果发现DBE术后患者未见小肠息肉引起的肠套叠或肠梗阻记录。结论 DBE可有效切除PJS患者小肠息肉，且治疗具有良好的安全性。
- 黑斑息肉综合征 /
- 双气囊小肠镜 /
- 内镜 /
- 小肠息肉
Abstract: Objective To investigate the efficacy and safety of double balloon enteroscopy (DBE) in the treatment of small intestinal polyps in patients with Peutz-Jeghers syndrome (PJS). Methods A retrospective analysis was conducted on PJS patients who underwent DBE at the Department of Gastroenterology, the First Affiliated Hospital of Anhui Medical University, from June 2020 to November 2023. Clinical data of the patients were collected, and the success rate of small intestinal polyps resection as well as the incidence of intraoperative and postoperative complications were recorded. Results A total of 12 patients (7 males, 5 females) with a mean age of (29.94±13.29) years were included in our study. A total of 20 DBE procedures were performed (15 via the oral approach, and 5 via the anal approach). The mean intubation depth were (306.00±126.71) cm and (220.00±34.64) cm, respectively. Among the 12 patients, jejunum polyps were most common (100.0%), with gastric polyps observed in 2 cases (16.7%) and colonic polyps in 2 cases (16.7%). The number and size of small intestinal polyps varied, with the largest measuring approximately 5.0 cm in diameter and the smallest 0.3 cm. The success rate of polypectomy was 100.0%, and no serious complications were associated with endoscopic treatment. Five patients had two or more hospitalizations, with no significant difference in the maximum polyps diameter between the first and second hospitalizations [(1.70±0.98) cm vs. (2.67±0.58) cm, t=1.467, P=0.216], though a decreasing trend was observed. Follow-up results revealed that no cases of intussusception or intestinal obstruction caused by small bowel polyps after DBE. Conclusion DBE is an effective and safe method for the removal of small bowel polyps in patients with PJS.
- Peutz-Jeghers syndrome /
- Double balloon enteroscopy /
- Endoscopy /
- Small intestine polyps

HTML全文

表 1 12例PJS患者小肠息肉的分布情况

Table 1. Distribution of small bowel polyps in 12 patients with PJS

患者序号	息肉位置
1	十二指肠、空肠
2	胃、十二指肠、空肠、回肠
3	空肠、十二指肠
4	空肠、十二指肠
5	胃、十二指肠、空肠、回肠、结肠
6	空肠
7	空肠
8	空肠、回肠
9	空肠
10	空肠、回肠、结肠
11	十二指肠、空肠
12	空肠、回肠

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表 2 12例PJS患者DBE治疗情况

Table 2. Status of DBE treatment in 12 patients with PJS

患者序号	住院次数	DBE例次	进镜方式	进镜深度(cm)	息肉最大直径(cm)
1	1	1	经口	350	2.5
2	1	2	经口	120	3.0
	2	3	经肛	200	2.0
	3	4	经口	360	2.5
3	1	5	经口	280	1.5
4	1	6	经口	130	5.0
5	1	7	经肛	200	2.0
	1	8	经口	260	1.5
	2	9	经肛	220	0.6
	2	10	经口	260	3.0
6	1	11	经口	270	4.0
7	1	12	经口	350	4.5
8	1	13	经口	500	1.5
	2	14	经肛	280	1.5
9	1	15	经口	420	3.0
	2	16	经口	300	2.0
10	1	17	经肛	200	1.2
	2	18	经口	210	4.0
11	1	19	经口	200	5.0
12	1	20	经口	580	2.3

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