胃复春片联合奥美拉唑肠溶胶囊治疗功能性消化不良的临床疗效

康年松; 黄戬; 钱蓉; 谷红苹; 韩旭丰; 苏文涛

doi:10.16766/j.cnki.issn.1674-4152.003459

胃复春片联合奥美拉唑肠溶胶囊治疗功能性消化不良的临床疗效

doi: 10.16766/j.cnki.issn.1674-4152.003459

康年松^1, ,,
黄戬²,
钱蓉³,
谷红苹⁴,
韩旭丰⁴,
苏文涛⁵

1.
余姚市中医医院治未病科, 浙江余姚 315400
2.
余姚市人民医院消化内科, 浙江余姚 315400
3.
余姚市人民医院康复医学科
4.
余姚市中医医院内科
5.
余姚市中医医院中医内科

基金项目:

浙江省中青年临床名中医项目浙中医药[2021]22号

浙江省医学会临床科研基金项目 2020ZYC-B0

详细信息

通讯作者:
康年松, E-mail: kangniansong@163.com

中图分类号: R57 R975.2
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- PDF下载量: 13
- 被引次数: 0
出版历程
- 收稿日期: 2023-10-31
- 网络出版日期: 2024-05-29

Clinical effect of Weifuchun tablets combined with omeprazole enteric-coated capsules in the treatment of functional dyspepsia

1.
Department of Treatment of Disease Department, Yuyao Hospital of Traditional Chinese Medicine, Yuyao, Zhejiang 315400, China

摘要

摘要: 目的探讨胃复春片联合奥美拉唑肠溶胶囊治疗功能性消化不良患者的临床效果，及其对血清胃蛋白酶原、胃泌素17的影响。方法采用随机数字表法将余姚市中医医院2021年10月—2022年12月收治的128例功能性消化不良患者分为胃复春组与莫沙必利组, 每组各64例。莫沙必利组给予奥美拉唑联合莫沙必利片治疗，胃复春组给予奥美拉唑联合胃复春片治疗，连续治疗4周后，比较2组患者的治疗效果、血清胃蛋白酶原、胃泌素17水平等。结果治疗4周后，胃复春组(87.50%, 56/64)的治疗总有效率高于莫沙必利组(71.88%, 46/64，χ²=4.827，P < 0.05)；胃复春组胃蛋白酶原Ⅰ[(113.20±10.21)μg/L]水平高于莫沙必利组[(98.26±9.64)μg/L，P < 0.05]，胃蛋白酶原Ⅱ[(17.21±2.58)μg/L]、胃泌素17[(15.31±2.09)pmol/L]水平均低于莫沙必利组[(20.31±3.11)μg/L、(18.22±2.67)pmol/L，P < 0.05]。结论胃复春片联合奥美拉唑肠溶胶囊治疗功能性消化不良患者临床症状改善明显，且能纠正血清胃蛋白酶原、胃泌素17水平的异常，提高患者的预后生活质量。
- 功能性消化不良 /
- 胃复春片 /
- 血清胃蛋白酶原 /
- 奥美拉唑 /
- 胃泌素17
Abstract: Objective To explore the clinical effect of Weifuchun tablets combined with omeprazole enteric-coated capsules on patients with functional dyspepsia and their influence on serum pepsinogen and gastrin-17 levels. Methods Using a random number table, 128 patients diagnosed with functional dyspepsia at Yuyao Hospital of Traditional Chinese Medicine between October 2021 and December 2022 were divided into two groups: Weifuchun group and Mosapride group, eaching consisting of 64 cases. The mosapride group was given a combination of omeprazole and Mosapride tablets, while the Weifuchun group was given a combination of omeprazole and Weifuchun tablets. After 4 weeks of continuous treatment, the therapeutic effect, serum pepsinogen, and gastrin-17 levels were compared between the two groups. Results After 4 weeks of treatment, the Weifuchun group demonstrated a higher total effective rate (87.50%, 56/64) compared to the Mosapride group (71.88%, 46/64), with a statistically significant difference (χ²=4.827, P < 0.05). The Weifuchun group also exhibited higher levels of pepsinogen Ⅰ [(113.20±10.21) μg/L] compared to the Moxapride group [(98.26±9.64) μg/L, P < 0.05]. Moreover, the Weifuchun group showed lower levels of pepsinogen Ⅱ[(17.21±2.58) μg/L] and gastrin-17 [(15.31±2.09) pmol/L] compared to the Mosapride group [(20.31±3.11) μg/L, (18.22±2.67) pmol/L, P < 0.05]. Conclusion The combination of Weifuchun tablets and omeprazole enteric-coated capsules significantly improves the clinical symptoms of patients with functional dyspepsia. It effectively corrects abnormal levels of serum pepsinogen and gastrin-17, leading to improved prognosis and enhanced quality of life for patients.
- Functional dyspepsia /
- Weifuchun tablets /
- Serum pepsinogen /
- Omeprazole /
- Gastrin-17

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表 1 2组功能性消化不良患者中医症状积分比较(x ± s，分)

Table 1. Comparison of TCM symptom scores between two groups of patients with functional dyspepsia(x ± s, points)

组别	例数	餐后饱胀不适		早饱感		中上腹痛		中上腹烧灼感
组别	例数	治疗前	4周后	治疗前	4周后	治疗前	4周后	治疗前	4周后
莫沙必利组	64	7.57±1.68	4.46±0.81^b	7.01±1.67	4.78±0.94^b	6.83±1.28	4.18±0.67^b	7.16±1.21	3.86±1.03^b
胃复春组	64	7.61±1.25	1.82±0.35^b	7.19±1.42	1.41±0.39^b	7.05±1.41	2.02±0.57^b	6.87±1.79	1.24±0.33^b
统计量		0.153^a	91.701^c	0.657^a	156.152^c	0.924^a	40.898^c	1.074^a	81.055^c
P值		0.879	< 0.001	0.512	< 0.001	0.357	< 0.001	0.285	< 0.001
注：^a为t值，^c为F值；与同组治疗前比较，^bP < 0.05。

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表 2 2组功能性消化不良患者中医症候疗效比较[例(%)]

Table 2. Comparison of curative effect of TCM symptoms between two groups of patients with functional dyspepsia[cases(%)]

组别	例数	显效	有效	无效	总有效
莫沙必利组	64	20(31.25)	26(40.63)	18(28.12)	46(71.88)
胃复春组	64	31(48.44)	25(39.06)	8(12.50)	56(87.50)
注：2组疗效比较，Z=6.238，P=0.442；2组总有效率比较，χ²=4.827，P=0.028。

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表 3 2组功能性消化不良患者生活质量改善情况比较(x ± s，分)

Table 3. Comparison of quality of life improvement between two groups of patients with functional dyspepsia (x ± s, points)

组别	例数	躯体功能		精神状况		社会认知
组别	例数	治疗前	4周后	治疗前	4周后	治疗前	4周后
莫沙必利组	64	60.52±3.26	78.56±7.26^b	35.12±3.65	57.15±6.22^b	55.26±4.31	67.45±6.20^b
胃复春组	64	61.27±4.52	85.26±6.88^b	36.84±4.11	63.25±5.86^b	54.67±5.12	74.52±5.21^b
统计量		1.077^a	27.143^c	2.503^a	44.386^c	0.705^a	49.512^c
P值		0.284	< 0.001	0.014	< 0.001	0.482	< 0.001
注：^a为t值，^c为F值；与同组治疗前比较，^bP < 0.05。

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表 4 2组功能性消化不良患者血清胃蛋白酶原、胃泌素17水平比较(x ± s)

Table 4. Comparison of serum pepsinogen and gastrin 17 levels between two groups of patients with functional dyspepsia(x ± s)

组别	例数	胃蛋白酶原Ⅰ(μg/L)		胃蛋白酶原Ⅱ(μg/L)		胃泌素17(pmol/L)
组别	例数	治疗前	4周后	治疗前	4周后	治疗前	4周后
莫沙必利组	64	80.11±6.21	98.26±9.64^b	25.61±4.12	20.31±3.11^b	21.03±3.26	18.22±2.67^b
胃复春组	64	79.68±7.16	113.20±10.21^b	26.02±3.26	17.21±2.58^b	20.86±2.88	15.31±2.09^b
统计量		0.363^a	52.753^c	0.624^a	17.283^c	0.313^a	21.890^c
P值		0.717	< 0.001	0.534	< 0.001	0.755	< 0.001
注：^a为t值，^c为F值；与同组治疗前比较，^bP < 0.05。

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