Curative effect of cement-enhanced PFNA on the elderly with osteoporotic intertrochanteric fracture
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摘要:
目的 观察应用骨水泥增强型股骨近端防旋髓内钉(PFNA)治疗老年骨质疏松性股骨转子间骨折的疗效和术后恢复情况,评价PFNA的应用效果。 方法 选取2020年1月—2022年1月聊城市人民医院收治的80例老年骨质疏松性股骨转子间骨折的患者,采用随机数字表法分为2组,PFNA组(40例)接受传统PFNA术,骨水泥增强组(40例)接受骨水泥增强型PFNA治疗,收集患者临床资料。术后12个月测量Harris评分,记录并发症发生情况。 结果 2组患者术中相关指标比较差异均无统计学意义(P>0.05)。骨水泥增强组患者下床时间[(5.08±0.96)d]、负重时间[(3.14±0.38)周]和骨折愈合时间[(12.33±1.29)周]均明显少于PFNA组[(7.37±1.01)d、(4.92±0.56)周、(17.64±1.75)周, P < 0.05]。术后12个月,PFNA组和骨水泥增强组患者疼痛、功能和肢体畸形髋关节Harris评分差异均无统计学意义(P>0.05),骨水泥增强组活动范围髋关节Harris评分明显高于PFNA组[(4.93±0.58)分vs. (4.61±0.52)分,P < 0.05]。骨水泥增强组患者并发症发生率明显低于PFNA组(P < 0.05)。 结论 骨水泥增强型PFNA术是治疗老年骨质疏松性股骨转子间骨折的理想术式,其安全性高,稳定性高,能够实现早期负重康复训练,有助于恢复关节功能。 Abstract:Objective To observe the effect and postoperative recovery of cement-enhanced proximal femoral nail anti-rotation (PFNA) in the treatment of the elderly with osteoporotic intertrochanteric fractures, and to evaluate the application effect of PFNA. Methods A total of 80 elderly patients with osteoporotic intertrochanteric fractures admitted to Liaocheng People's Hospital were enrolled from January 2020 to January 2022. According to the random grouping method, they were divided into the PFNA group (traditional PFNA, n=40) and the cement-enhanced group (cement-enhanced PFNA, n=40). The clinical data of patients were collected. Twelve months after surgery, the Harris score was measured, and the occurrence of complications was recorded. Results There was no significant difference in intraoperative relevant indexes between the two groups (P>0.05). The leaving bedtime, weight-bearing time, and fracture healing time in the cement-enhanced group were (5.08±0.96) d, (3.14±0.38) weeks and (12.33±1.29) weeks, which were significantly shorter than those in PFNA group [(7.37±1.01) d, (4.92±0.56) weeks, (17.64±1.75) weeks, P < 0.05]. Twelve months after surgery, there was no significant difference in hip Harris scores (pain, function, limb deformity) between the two groups (P>0.05), but the hip Harris score (range of motion) in the cement-enhanced group was significantly higher than that in the PFNA group [(4.93±0.58) points vs. (4.61±0.52) points, P < 0.05]. The incidence of complications in the cement-enhanced group was significantly lower than that in the PFNA group (P < 0.05). Conclusion Cement-enhanced PFNA is an ideal operation in the treatment of the elderly with osteoporotic intertrochanteric fracture, with high safety and stability. It can realize early weight-bearing rehabilitation training and is beneficial to recover joint function. -
表 1 PFNA组和骨水泥增强组老年骨质疏松性股骨转子间骨折患者一般资料比较
Table 1. Comparison of general data in elderly patients with osteoporotic intertrochanteric fracture between PFNA group and cement-enhanced group
项目 PFNA组
(n=40)骨水泥增强组
(n=40)统计量 P值 性别[例(%)] 1.867a 0.172 女性 29(72.50) 34(85.00) 男性 11(27.50) 6(15.00) 年龄(x±s, 岁) 71.73±8.59 72.36±8.68 0.326b 0.745 骨密度T值(x±s) -2.94±0.25 -2.88±0.31 0.953b 0.344 骨折部位[例(%)] 0.450a 0.502 左侧 22(55.00) 19(47.50) 右侧 18(45.00) 21(52.50) AO分型[例(%)] 0.312a 0.576 A2 31(77.50) 33(82.50) A3 9(22.50) 7(17.50) 骨折原因[例(%)] 0.957a 0.620 摔伤 32(80.00) 30(75.00) 交通伤 5(12.50) 8(20.00) 其他 3(7.50) 2(5.00) Evans分型[例(%)] 0.341c 0.557 Ⅰ 6(15.00) 9(22.50) Ⅱ 8(20.00) 6(15.00) Ⅲ 14(35.00) 15(37.50) Ⅳ 7(17.50) 6(15.00) Ⅴ 5(12.50) 4(10.00) 合并症[例(%)] 糖尿病 6(15.00) 4(10.00) 0.457a 0.499 高血压 11(27.50) 12(30.00) 0.061a 0.805 心功能不全 3(7.50) 5(12.50) 0.556a 0.456 注:a为χ2值,b为t值,c为Z值。 表 2 PFNA组和骨水泥增强组老年骨质疏松性股骨转子间骨折患者手术情况比较(x±s)
Table 2. Comparison of surgical situations in elderly patients with osteoporotic intertrochanteric fracture between PFNA group and cement-enhanced group (x±s)
组别 例数 术中出血量
(mL)总输血量
(mL)手术用时
(min)PFNA组 40 161.47±21.31 206.58±57.05 53.48±7.90 骨水泥增强组 40 160.85±21.46 185.23±51.28 55.76±8.25 t值 0.130 1.760 1.262 P值 0.897 0.082 0.211 表 3 PFNA组和骨水泥增强组老年骨质疏松性股骨转子间骨折的患者术后恢复情况比较(x±s)
Table 3. Comparison of postoperative recovery in elderly patients with osteoporotic intertrochanteric fracture between PFNA group and cement-enhanced group (x±s)
组别 例数 下床时间
(d)负重时间
(周)骨折愈合时间
(周)PFNA组 40 7.37±1.01 4.92±0.56 17.64±1.75 骨水泥增强组 40 5.08±0.96 3.14±0.38 12.33±1.29 t值 10.394 16.635 15.447 P值 < 0.001 < 0.001 < 0.001 注:骨折愈合时间定义为影像学显示有明显骨小梁穿过骨折线。 表 4 PFNA组和骨水泥增强组老年骨质疏松性股骨转子间骨折的患者髋关节Harris评分比较(x±s, 分)
Table 4. Comparison of hip Harris scores in elderly patients with osteoporotic intertrochanteric fracture between PFNA group and cement-enhanced group (x±s, points)
组别 例数 疼痛 功能 活动范围 肢体畸形 PFNA组 40 39.76±3.25 40.47±4.31 4.61±0.52 3.85±0.23 骨水泥增强组 40 40.48±2.91 41.88±4.46 4.93±0.58 3.94±0.19 t值 1.044 1.438 2.598 1.908 P值 0.300 0.154 0.011 0.060 表 5 PFNA组和骨水泥增强组老年骨质疏松性股骨转子间骨折的患者并发症发生情况比较
Table 5. Comparison of complications in elderly patients with osteoporotic intertrochanteric fracture between PFNA group and cement-enhanced group
组别 例数 髋内翻(例) 再骨折(例) 螺旋刀片切出(例) 感染(例) 合计[例(%)] PFNA组 40 1 2 5 3 11(27.50) 骨水泥增强组 40 0 1 0 2 3(7.50) 注:2组并发症发生率比较,χ2=5.541,P=0.019。 -
[1] JOHNSTON C B, DAGAR M. Osteoporosis in older adults[J]. Med Clin North Am, 2020, 104(5): 873-884. doi: 10.1016/j.mcna.2020.06.004 [2] CHANG S M, HOU Z Y, HU S J, et al. Intertrochanteric femur fracture treatment in Asia: what we know and what the world can learn[J]. Orthop Clin North Am, 2020, 51(2): 189-205. doi: 10.1016/j.ocl.2019.11.011 [3] 周平辉, 乐意, 张知理, 等. PFNA联合抗骨质疏松药物治疗高龄患者股骨转子间骨折的疗效比较[J]. 中华全科医学, 2019, 17(6): 920-923. doi: 10.16766/j.cnki.issn.1674-4152.000825ZHOU P H, LE Y, ZHANG Z L, et al. Clinical efficacy of PFNA with anti-osteoporosis drugs in the treatment of intertrochanteric fracture in elderly patients[J]. Chinese Journal of General Practice, 2019, 17(6): 920-923. doi: 10.16766/j.cnki.issn.1674-4152.000825 [4] LIU W, LIU J, JI G R. Comparison of clinical outcomes with proximal femoral nail anti-rotation versus InterTAN nail for intertrochanteric femoral fractures: a meta-analysis[J]. J Orthop Surg Res, 2020, 15(1): 500. doi: 10.1186/s13018-020-02031-8 [5] IBRAHIM I, APPLETON P T, WIXTED J J, et al. Implant cut-out following cephalomedullary nailing of intertrochanteric femur fractures: are helical blades to blame?[J]. Injury, 2019, 50(4): 926-930. doi: 10.1016/j.injury.2019.02.015 [6] 中国老年学学会骨质疏松委员会. 中国人骨质疏松症诊断标准专家共识(第三稿·2014版)[J]. 中国骨质疏松杂志, 2014, 20(9): 1007-1010. https://www.cnki.net/KCMS/detail/detail.aspx?dbcode=IPFD&filename=LNGZ201504001116&dbname=IPFDLAST2015Osteoporosis Committee of Gerontological Society of China. Expert consensus on the diagnosis of osteoporosis in Chinese Population[J]. Chinese Journal of Osteoporosis, 2014, 20(9): 1007-1010. https://www.cnki.net/KCMS/detail/detail.aspx?dbcode=IPFD&filename=LNGZ201504001116&dbname=IPFDLAST2015 [7] 中国老年医学学会骨与关节分会创伤骨科学术工作委员会. 老年髋部骨折诊疗专家共识(2017)[J]. 中华创伤骨科杂志, 2017, 19(11): 921-927. https://www.cnki.com.cn/Article/CJFDTOTAL-ZGJW202108001.htmTrauma Orthopaedics Academic Working Committee of Bone and Joint Branch of Chinese Geriatric Society. Experts' consensus on diagnosis and management of geriatric hip fractures (2017)[J]. Chinese Journal of Orthopaedic Trauma, 2017, 19(11): 921-927. https://www.cnki.com.cn/Article/CJFDTOTAL-ZGJW202108001.htm [8] 杨雨润, 陈瀛, 林朋, 等. 不同长度股骨近端髓内钉治疗合并骨质疏松的不稳定型股骨转子间骨折的疗效分析[J]. 中华创伤骨科杂志, 2022, 24(4): 350-354. https://www.cnki.com.cn/Article/CJFDTOTAL-HZZZ201624008.htmYANG Y R, CHEN Y, LIN P, et al. Lengths of intramedullary nails and treatment efficacy of osteoporotic unstable intertrochanteric fracture[J]. Chinese Journal of Orthopaedic Trauma, 2022, 24(4): 350-354. https://www.cnki.com.cn/Article/CJFDTOTAL-HZZZ201624008.htm [9] CLYNES M A, HARVEY N C, CURTIS E M, et al. The epidemiology of osteoporosis[J]. Br Med Bull, 2020, 133(1): 105-117. [10] 涂刚成, 毛华晋, 汪盛玉, 等. 骨水泥强化股骨近端防旋髓内钉内固定治疗股骨转子间骨折对髋关节功能恢复的影响[J]. 中国临床医生杂志, 2022, 50(3): 344-347. https://www.cnki.com.cn/Article/CJFDTOTAL-ZLYS202203027.htmTU G C, MAO H J, WANG S Y, et al. Effect of bone cement-enhanced proximal femoral nail antirotation on recovery of hip function in intertrochanteric fracture of femur[J]. Chinese Journal for Clinicians, 2022, 50(3): 344-347. https://www.cnki.com.cn/Article/CJFDTOTAL-ZLYS202203027.htm [11] 陈心敏, 李文标, 熊凯凯, 等. 钉道强化股骨近端防旋髓内钉治疗老年A3.3型股骨转子间骨折: 最佳骨水泥量有限元分析[J]. 中国组织工程研究, 2021, 25(9): 1404-1409. https://www.cnki.com.cn/Article/CJFDTOTAL-XDKF202109020.htmCHEN X M, LI W B, XIONG K K, et al. Type A3.3 femoral intertrochanteric fracture with augmented proximal femoral nail anti-rotation in the elderly: finite element analysis of the optimal amount of bone cement[J]. Chinese Journal of Tissue Engineering Research, 2021, 25(9): 1404-1409. https://www.cnki.com.cn/Article/CJFDTOTAL-XDKF202109020.htm [12] MONZÓN R A, COURY J G, DISSE G D, et al. Bone cement in total hip and knee arthroplasty[J]. JBJS Rev, 2019, 7(12): e6. DOI: 10.2106/JBJS.RVW.19.00031. [13] 孟纬, 潘昊鹏, 李尧. 骨水泥增强技术治疗椎体压缩性骨折临床疗效观察[J]. 齐齐哈尔医学院学报, 2020, 41(9): 1083-1086. https://www.cnki.com.cn/Article/CJFDTOTAL-QQHB202009009.htmMENG W, PAN H P, LI Y. Observation on the clinical efficacy of bone cement enhancement technique in the treatment of vertebral compression fracture[J]. Journal of Qiqihar Medical University, 2020, 41(9): 1083-1086. https://www.cnki.com.cn/Article/CJFDTOTAL-QQHB202009009.htm [14] 孙金山, 马斌. 股骨近端防旋转髓内钉联合鲑鱼降钙素治疗老年股骨粗隆间骨折的疗效及对骨密度的影响[J]. 解放军预防医学杂志, 2019, 37(4): 94-95. https://www.cnki.com.cn/Article/CJFDTOTAL-JYYX201904047.htmSUN J S, MA B. Curative effect of proximal femoral nail antirotation combined with salmon calcitonin on the elderly with intertrochanteric fracture of femur and its influences on bone mineral density[J]. Journal of Preventive Medicine of Chinese People ' s Liberation Army, 2019, 37(4): 94-95. https://www.cnki.com.cn/Article/CJFDTOTAL-JYYX201904047.htm [15] RADAIDEH A M, QUDAH H A, AUDAT Z A, et al. Functional and radiological results of proximal femoral nail antirotation (PFNA) osteosynthesis in the treatment of unstable pertrochanteric fractures[J]. J Clin Med, 2018, 7(4): 78. doi: 10.3390/jcm7040078 [16] 常焕武. PFNA术治疗老年高龄骨质疏松性股骨转子间骨折安全性和疗效分析[J]. 中国药物与临床, 2020, 20(12): 1999-2001. https://www.cnki.com.cn/Article/CJFDTOTAL-YWLC202012040.htmCHANG H W. Safety and effect of PFNA in the treatment of the elderly with osteoporotic intertrochanteric fracture of femur[J]. Chinese Remedies & Clinics, 2020, 20(12): 1999-2001. https://www.cnki.com.cn/Article/CJFDTOTAL-YWLC202012040.htm [17] MORVAN A, BODDAERT J, COHEN-BITTAN J, et al. Risk factors for cut-out after internal fixation of trochanteric fractures in elderly subjects[J]. Orthop Traumatol Surg Res, 2018, 104(8): 1183-1187. doi: 10.1016/j.otsr.2018.06.021 [18] 陈宏峰, 杨冬松, 凌建生, 等. 骨水泥强化型股骨近端防旋髓内钉固定治疗严重骨质疏松性股骨转子间骨折[J]. 中华创伤骨科杂志, 2020, 22(3): 259-260, 262.CHEN H F, YANG D S, LING J S, et al. Bone cement-enhanced proximal femoral nail antirotation for treatment of severe osteoporotic intertrochanteric fracture[J]. Chinese Journal of Orthopaedic Trauma, 2020, 22(3): 259-262. [19] 王勇, 尤炯鸣, 吴银生, 等. 标准骨水泥强化型与传统股骨近端防旋髓内钉治疗老年骨质疏松性股骨转子间不稳定骨折的疗效比较[J]. 中华创伤杂志, 2020, 36(12): 1077-1082. https://www.cnki.com.cn/Article/CJFDTOTAL-ZYZG202310004.htmWANG Y, YOU J M, WU Y S, et al. Standard bone cement augmented and traditional proximal femoral nail antirotation for treatment of elderly osteoporotic patients with femoral inter-trochanteric unstable fractures: a comparative study[J]. Chinese Journal of Trauma, 2020, 36(12): 1077-1082. https://www.cnki.com.cn/Article/CJFDTOTAL-ZYZG202310004.htm -

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