针灸埋线法联合礞石滚痰汤治疗痰湿内阻型多囊卵巢综合征的临床疗效

徐道芬; 胡欣欣; 高楚楚; 陈蕾蕾; 马大正; 孙云

doi:10.16766/j.cnki.issn.1674-4152.003348

针灸埋线法联合礞石滚痰汤治疗痰湿内阻型多囊卵巢综合征的临床疗效

doi: 10.16766/j.cnki.issn.1674-4152.003348

温州市中医院妇科，浙江温州 325000

基金项目:

浙江省中医药科技计划项目 2019ZB121

温州市基础性医疗卫生科技项目 Y2020196

温州市重大科技创新攻关项目 ZY2022014

浙江中医药大学附属医院科研项目 2022FSYYZZ28

详细信息

通讯作者:
徐道芬，E-mail：wzxudaofen@126.com

中图分类号: R711.75 R245
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- 文章访问数: 80
- HTML全文浏览量: 23
- PDF下载量: 4
- 被引次数: 0
出版历程
- 收稿日期: 2023-09-14
- 网络出版日期: 2024-03-09

Clinical efficacy of acupuncture catgut embedding combined with Hushi Guntan decoction in treating polycystic ovary syndrome with phlegm-dampness internal resistance

Department of Gynecology, Wenzhou Hospital of Traditional Chinese Medicine, Wenzhou, Zhejiang 325000, China

摘要

摘要: 目的分析针灸埋线法及礞石滚痰汤联合来曲唑在痰湿内阻型多囊卵巢综合患者中的应用价值。方法采用随机数字表法将2021年10月—2022年10月于温州市中医院接受治疗的115例痰湿内阻型多囊卵巢综合征患者分为2组，对照组57例，采用来曲唑治疗，治疗组58例，在对照组的基础上采用针灸埋线法联合礞石滚痰汤治疗。对比2组患者的性激素、糖脂代谢指标、卵巢多囊样改变等。结果治疗组的促黄体生成素[(8.76±2.08)U/L]等性激素水平低于对照组[(10.28±2.29)U/L，t=3.724，P < 0.05]；治疗组的糖化血红蛋白[(4.91±0.91)%]等糖脂代谢指标低于对照组[(5.29±0.87)%，t= 2.289，P < 0.05]；治疗组的卵巢体积[(6.52±0.95)cm³]小于对照组[(7.66±1.02)cm³，t=6.200，P < 0.05]；治疗组的排卵(86.21%，50/58)和妊娠(60.34%，35/58)比例均高于对照组[68.42%(39/57)、38.60%(22/57)，χ²=5.197、5.439，P < 0.05]。结论针灸埋线法联合礞石滚痰汤可以降低痰湿内阻型多囊卵巢综合征患者的BMI和腰臀比，改善性激素、糖脂代谢水平及卵巢多囊样改变，恢复正常排卵以提高妊娠率。
- 多囊卵巢综合征 /
- 针灸埋线 /
- 痰湿内阻 /
- 礞石滚痰汤 /
- 内分泌
Abstract: Objective The purpose of this study is to analyze the application value of acupuncture and catgut embedding and Hushi Guntan Decoction combined with letrozole in patients with polycystic ovary syndrome with phlegm-dampness internal resistance. Methods According to the random number table method, 115 patients with polycystic ovary syndrome with phlegm-dampness internal resistance who were treated in Wenzhou Traditional Chinese Medicine Hospital from October 2021 to October 2022 were divided into two groups. A total of 57 cases in the control group were treated with letrozole, and 58 cases in the treatment group were treated with acupuncture and catgut embedding combined with Hushi Guntan Decoction on the basis of the control group. The levels of sex hormones, glucose and lipid metabolism indexes and polycystic ovarian changes were compared between the two groups. Results The levels of LH [(8.76±2.08) U/L] and other sex hormones in the treatment group were lower than those in the control group [(10.28±2.29) U/L, t=3.724, P < 0.05]. Glycolipid metabolism levels such as HbA1c [(4.91±0.91)%] in the treatment group were lower than those in the control group [(5.29±0.87)%, t= 2.289, P < 0.05]. The ovarian volume in the treatment group [(6.52±0.95) cm³] was smaller than that in the control group [(7.66±1.02) cm³, t=6.200, P < 0.05]. The rates of ovulation (86.21%, 50/58) and pregnancy (60.34%, 35/58) in the treatment group were higher than those in the control group [68.42% (39/57), 38.60% (22/57), χ²=5.197, 5.439, P < 0.05]. Conclusion Acupuncture and catgut embedding combined with Hushi Guntan Decoction can reduce BMI and waist-to-hip ratio, improve the levels of sex hormones, glucose and lipid metabolism and polycystic ovarian changes, restore normal ovulation and increase pregnancy rate.
- Polycystic ovary syndrome /
- Acupuncture catgut embedding /
- Internal resistance of phlegm-dampness /
- Hushi Guntan Decoction /
- Internal secretion

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表 1 2组痰湿内阻型多囊卵巢综合征患者BMI、WHR比较(x±s)

Table 1. Comparison of BMI and WHR between two groups of polycystic ovary syndrome patients with phlegm-dampness internal resistance(x±s)

组别	例数	BMI		WHR
组别	例数	治疗前	3个月后	治疗前	3个月后
对照组	57	27.55±2.11	25.16±1.78^a	0.88±0.07	0.85±0.04^a
治疗组	58	28.07±1.85	23.87±2.02^a	0.87±0.06	0.82±0.06^a
t值		1.404	3.635	0.822	3.160
P值		0.163	< 0.001	0.413	0.002
注：与同组治疗前比较，^aP < 0.05。

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表 2 2组痰湿内阻型多囊卵巢综合征患者性激素比较(x±s)

Table 2. Comparison of sex hormone levels between two groups of polycystic ovary syndrome patients with phlegm-dampness internal resistance(x±s)

组别	例数	LH(U/L)		LH/FSH		T(μg/L)
组别	例数	治疗前	3个月后	治疗前	3个月后	治疗前	3个月后
对照组	57	13.49±2.19	10.28±2.29^a	1.70±0.61	0.99±0.31^a	58.31±6.79	53.26±5.37^a
治疗组	58	14.05±2.44	8.76±2.08^a	1.72±0.58	0.81±0.24^a	59.15±7.31	50.17±5.84^a
t值		1.296	3.724	0.180	3.478	0.639	2.954
P值		0.198	< 0.001	0.857	0.001	0.524	0.004
注：与同组治疗前比较，^aP < 0.05。

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表 3 2组痰湿内阻型多囊卵巢综合征患者糖脂代谢指标比较(x±s)

Table 3. Comparison of glucose and lipid metabolism between two groups of polycystic ovary syndrome patients with phlegm-dampness resistance(x±s)

组别	例数	HbA1c(%)		FINS(nmol/L)		HOMA-IR		TC(mmol/L)		TG(mmol/L)
组别	例数	治疗前	3个月后	治疗前	3个月后	治疗前	3个月后	治疗前	3个月后	治疗前	3个月后
对照组	57	5.82±1.09	5.29±0.87^a	23.26±4.18	14.26±2.48^a	5.44±0.88	3.46±0.71^a	5.42±1.37	4.69±1.05^a	2.44±0.48	1.94±0.26^a
治疗组	58	5.79±1.12	4.91±0.91^a	22.65±5.03	9.14±1.53^a	5.37±0.94	2.01±0.56^a	5.56±1.42	4.18±0.97^a	2.39±0.45	1.29±0.19^a
t值		0.146	2.289	0.708	13.297	0.412	12.146	0.538	2.704	0.576	15.285
P值		0.885	0.024	0.481	< 0.001	0.681	< 0.001	0.592	0.008	0.566	< 0.001
注：与同组治疗前比较，^aP < 0.05。

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表 4 2组痰湿内阻型多囊卵巢综合征患者卵巢多囊样改变及子宫内膜厚度比较(x±s)

Table 4. Comparison of polycystic ovary changes and endometrial thickness between two groups of polycystic ovary syndrome patients with phlegm-dampness internal resistance(x±s)

组别	例数	卵巢体积(cm³)		卵泡数目(个)		子宫内膜厚度(mm)
组别	例数	治疗前	3个月后	治疗前	3个月后	治疗前	3个月后
对照组	57	9.84±1.31	7.66±1.02^a	13.06±3.11	9.38±1.83^a	6.19±0.66	8.17±1.03^a
治疗组	58	9.77±1.45	6.52±0.95^a	12.87±2.94	7.41±1.37^a	6.51±0.73	9.73±1.16^a
t值		0.272	6.200	0.337	6.526	1.720	7.629
P值		0.786	< 0.001	0.369	< 0.001	0.088	< 0.001
注：与同组治疗前比较，^aP < 0.05。

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表 5 2组痰湿内阻型多囊卵巢综合征患者排卵及妊娠情况比较[例(%)]

Table 5. Comparison of ovulation and pregnancy between two groups of polycystic ovary syndrome patientswith phlegm-dampness resistance[cases (%)]

组别	例数	排卵	妊娠
对照组	57	39(68.42)	22(38.60)
治疗组	58	50(86.21)	35(60.34)
χ²值		5.197	5.439
P值		0.023	0.020

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