Visual analysis of traditional Chinese medicine in the treatment of diabetic cardiomyopathy based on CiteSpace
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摘要:
目的 通过CiteSpace软件分析近30年中医药治疗糖尿病心肌病(diabetic cardiomyopathy，DCM)相关文献，梳理该领域研究现状、研究热点及发展趋势，以期为后续的研究提供参考。 方法 检索中国知网从建库至2022年12月中医药治疗DCM的有关文献，利用CiteSpace 6.1.R6软件对文献发文量、作者、机构、关键词、突现词进行可视化分析。 结果 共检索出608篇文献，按照纳入排除标准筛选后最终纳入548篇文献。本领域相关研究的发文量总体呈上升趋势，共出现35名核心作者，并形成了多个成员数目不等的作者合作团队。发文量排名前10位的机构累计发表文献共152篇(27.7%)，按发文量排名前3位分别为黑龙江中医药大学、中国中医科学院、山东中医药大学。分析后得到315个关键词、10个关键词聚类团及16个突现词。关键词共现图显示动物实验、氧化应激、细胞凋亡研究频次较高；关键词聚类涉及丹参饮、生脉饮、炙甘草汤等成方及葛根素、黄芪、灵芝多糖等有效中药成分对DCM的疗效观察及深层机制；突现词分析显示氧化应激、自噬、凋亡、炎症为近年热点研究方向。 结论 通过知识图谱直观地呈现出中医药治疗糖尿病心肌病的研究现状，我国研究热点为单味中药及提取物、中药复方对DCM的效应机制研究，研究者可重点挖掘氧化应激、炎症、自噬、凋亡在中医药治疗DCM中的作用。 Abstract:Objective To analyze the literature related to the treatment of diabetic cardiomyopathy (DCM) with traditional Chinese medicine (TCM) over the past 30 years using CiteSpace software, and to sort out the research status, research hotspots and development trends in this field, so as to provide a reference for the follow-up research. Methods Literature on DCM treated with TCM was retrieved from the CNKI database from its inception to December 2022. CiteSpace 6.1.R6 software was used to visually analyze the number of literatures, authors, institutions, keywords and emergent words. Results A total of 608 articles were retrieved and 548 articles were finally included after screening against the inclusion and exclusion criteria. The number of papers published in this area is generally increasing, with a total of 35 core authors, and a number of collaborative teams with different members have been formed. The top 10 institutions published a total of 152 articles (27.7%) and the top three were Heilongjiang University of Chinese Medicine, China Academy of Chinese Medical Sciences and Shandong University of Chinese Medicine. After analyzing, 315 keywords, 10 keyword clusters and 16 emerging words were obtained. The keyword co-occurrence map showed that animal experiments, oxidative stress and apoptosis were frequently studied. Keywords Clustering includes the observation of therapeutic effect and deep mechanism of DCM from Salvia miltiorrhiza decoction, pulse-making decoction and decoctions, Pueraria, Astragalus and Ganoderma polysaccharides. The analysis of emergent words showed that oxidative stress, autophagy, apoptosis and inflammation were the hottest research areas in recent years. Conclusion The current research hotspots in this field are the mechanism of action of single Chinese medicines, extracts and compound Chinese medicines on DCM, and the research hotspots mainly include the role of oxidative stress, inflammation, autophagy and apoptosis in the treatment of DCM with Chinese medicine. -
Key words:
- Diabetic cardiomyopathy /
- Traditional Chinese medicine /
- CiteSpace /
- Visual analysis
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图 4 中医药治疗DCM的关键词聚类图
Figure 4. Diagram illustrating keyword clustering in TCM treatment of DCM
表 1 中医药治疗DCM相关文献的关键词聚类列表
Table 1. List of keyword clusters in literature regarding TCM treatment for DCM
聚类 规模 年份 标签(LLR) #0 44 2016 氧化应激(20.07, 0.000 1);炎症(20.07, 0.000 1);糖尿病(13.97, 0.001);炎症反应(12.09, 0.001);信号通路(11.5, 0.001) #1 41 2013 细胞凋亡(25.83, 0.000 1);心肌细胞(25.49, 0.000 1);凋亡(25.12, 0.000 1);葛根素(13.94, 0.001);丹参饮(12.43, 0.001) #2 37 2013 糖心康(21.47, 0.000 1);糖尿病(18.38, 0.000 1);消渴(16.09, 0.000 1);胸痹(10.68, 0.005);临床效果(7.11, 0.01) #3 31 2010 大鼠(47.52, 0.000 1);心肌(19.04, 0.000 1);自噬(19.04, 0.000 1);动物实验(15.2, 0.000 1);血糖(14.52, 0.001) #4 26 2011 黄芪(25.48, 0.000 1);心肌病(22.89, 0.000 1);灵芝多糖(10.11, 0.005);分子对接(10.11, 0.005);糖尿病心肌病(5.11, 0.05) #5 25 2011 中医药(26.91, 0.000 1);中药(21.46, 0.000 1);综述(16.6, 0.000 1);治疗(16.05, 0.000 1);发病机制(16.05, 0.000 1) #6 18 2010 实验研究(18.36, 0.000 1);动物(12.19, 0.001);作用机制(11.81, 0.001);实验性(6.84, 0.01);靶点(6.07, 0.05) #7 11 2012 心率(15.06, 0.001);心力衰竭(15.06, 0.001);注射剂(7.48, 0.01);室性早搏(7.48, 0.01);硝酸(7.48, 0.01) #8 9 2008 生脉饮(16.49, 0.000 1);黄芪桂枝五物汤(8.17, 0.005);心脏功能(8.17, 0.005);阴阳两虚(8.17, 0.005);炙甘草(8.17, 0.005) #9 9 2010 炙甘草汤(19.29, 0.000 1);卡托普利(15.71, 0.000 1);糖尿病性心肌病(9.17, 0.005);安全性(7.8, 0.01);心律失常(7.8, 0.01) 注：LLR为对数似然比(log likelihood ratio)。括号内分别为LLR值、P值。LLR值越大表明越具有聚类代表性。 
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表 2 治疗DCM的单味中药及复方
Table 2. Chinese medicine and compound formulations for the treatment of DCM
单味中药及提取物 中药复方 黄芪、黄芪多糖 炙甘草汤 白藜芦醇 生脉饮 葛根素 丹参饮 灵芝多糖 糖心康 小檗碱 黄芪桂枝五物汤
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