Longitudinal study of gestational psychological health and sleep quality
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摘要:
目的 探讨孕期女性心理健康状态、睡眠质量变化,分析孕期睡眠质量影响因素。 方法 选择2020年1月—2021年12月于上海交通大学医学院附属国际和平妇幼保健院产检的3 904例自然受孕女性为研究对象,使用焦虑自评量表(SAS)、抑郁自评量表(CES-D)、压力感知量表(PSS-10)、匹兹堡睡眠质量指数(PSQI)评估孕早期(10~14孕周)、孕中期(20~24孕周)、孕晚期(28~32孕周)女性的心理健康状态和睡眠质量,分析睡眠质量影响因素。 结果 孕早期女性的焦虑、抑郁、有压力占比分别为11.83%、42.32%、71.47%,较孕中、晚期高;孕早、中、晚期睡眠质量问题占比分别为14.81%、50.59%、16.14%;线性混合模型分析显示,焦虑(B=0.548,P<0.001)、抑郁(B=0.768,P<0.001)、压力(B=0.649,P=0.002)、年龄(B=0.646,P=0.023)、大专及以上学历(B=0.699,P=0.023)、无业(B=0.429,P=0.004)、家庭收入(B=0.452,P=0.039)、孕次(B=0.608,P=0.044)、产次(B=0.606,P=0.017)是孕期女性睡眠质量问题的影响因素(均P<0.05),随机截距模型显示随着孕期时间增加,孕期不同女性睡眠质量变化趋势相同(B=9.621,P<0.001)。 结论 孕期女性易出现焦虑、抑郁、压力等心理问题,且孕期心理健康与睡眠质量息息相关,妇幼专科技术人员应及时关注孕早期心理状况及孕期睡眠质量。 Abstract:Objective To explore changes of gestational psychological health and sleep quality in women, and to analyze influencing factors of sleep quality. Methods A total of 3 904 natural conception women undergoing antenatal examinations in the International Peace Maternity & Child Health Hospital, Shanghai Jiao Tong University School of Medicine were enrolled as the research objects from January 2020 to December 2021. The psychological health and sleep quality of women in early (10-14 gestational weeks), middle (20-24 gestational weeks) and late pregnancy (28-32 gestational weeks) were evaluated by self-rating anxiety scale (SAS), the center for epidemiological studies depression scale (CES-D), the perceived stress scale (PSS-10) and Pittsburgh sleep quality index (PSQI), and influencing factors of sleep quality were analyzed. Results In early pregnancy, proportions of anxiety, depression and stress were 11.83%, 42.32% and 71.47%, which were higher than those in middle and late pregnancy. The proportions of sleep disorders in early, middle and late pregnancy were 14.81%, 50.59% and 16.14%, respectively. Linear mixed model analysis showed that anxiety (B=0.548, P<0.001), depression (B=0.768, P<0.001), stress (B=0.649, P=0.002), age (B=0.646, P=0.023), education level of college degree or above (B=0.699, P=0.023), unemployment (B=0.429, P=0.004), family income (B=0.452, P=0.039), gravidity (B=0.608, P=0.044) and parity (B=0.606, P=0.017) were influencing factors of sleep disorders (all P<0.05). The random intercept model showed that with the increase of pregnant time, the change trend of sleep quality was the same in women with different gestational periods (B=9.621, P<0.001). Conclusion The incidence of psychological problems (anxiety, depression, stress) is high in women during pregnancy. Gestational psychological health is closely related to sleep quality. Professional staffs for women and children should pay attentions to psychological status in early pregnancy and sleep quality during pregnancy. -
Key words:
- Woman during pregnancy /
- Gestational period /
- Anxiety /
- Stress /
- Depression /
- Sleep quality /
- Correlation
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表 1 自然受孕女性人口学特征分布情况
Table 1. Distribution of demographic characteristics of naturally conceived women
人口学特征 例数(%) 人口学特征 例数(%) 年龄(岁) 家庭收入(元/年) ≥30 2 031(52.02) ≥10万 2 221(56.89) <30 1 873(47.98) <10万 1 683(43.11) BMI 孕次(次) ≥24 1 030(26.38) ≥3 2 600(66.60) <24 2 874(73.62) <3 1 304(33.40) 居住地 产次(次) 城市 1 406(36.01) ≥3 1 332(34.12) 城郊 1 727(44.24) <3 2 572(65.88) 农村 771(19.75) 饮食不佳 922(23.62) 学历 饮酒 665(17.03) 初中及以下 913(23.39) 被动烟草暴露 734(18.80) 高中或中专 1 728(44.26) 经前紧张综合征 993(25.44) 大专及以上 1 263(32.35) 职业 职员 2 270(58.15) 个体户 1 018(26.08) 无业 616(15.78) 表 2 不同孕期女性的心理健康状态和睡眠质量情况[例(%)]
Table 2. Mental health status and sleep quality of women during different pregnancies[cases (%)]
孕期 例数 焦虑 抑郁 有压力 睡眠质量问题 孕早期 3 904 462(11.83) 1 652(42.32) 2 790(71.47) 578(14.81) 孕中期 3 904 184(4.71)a 796(20.39)a 1 950(49.95)a 1 975(50.59)a 孕晚期 3 904 248(6.35)ab 848(21.72)a 1 772(45.39)ab 630(16.14)b Wald χ2值 114.361 468.047 569.430 1 349.441 P值 <0.001 <0.001 <0.001 <0.001 注:与孕早期比较,aP<0.05;与孕中期比较,bP<0.05。 表 3 不同孕期女性不良睡眠质量发生相关因素分析
Table 3. Analysis of related factors of poor sleep quality in women during different pregnancies
项目 孕早期
(n=578)χ2值 P值 孕中期
(n=1 975)χ2值 P值 孕晚期
(n=630)χ2值 P值 年龄(岁) 29.588 <0.001 15.546 <0.001 19.919 <0.001 ≥30 361 1 089 379 <30 217 886 251 孕前BMI 0.589 0.443 0.136 0.713 0.076 0.783 ≥24 160 516 169 <24 418 1 459 461 居住地 20.308 <0.001 90.790 <0.001 66.629 <0.001 城市 181 671 198 城郊 244 796 233 农村 153 508 199 学历 28.717 <0.001 32.766 <0.001 11.037 0.004 初中及以下 156 491 165 高中或中专 197 786 241 大专及以上 225 698 224 职业 43.258 <0.001 19.216 <0.001 33.015 <0.001 职员 292 1 134 325 个体户 142 482 158 无业 144 359 147 家庭收入(元/年) 24.890 <0.001 27.133 <0.001 15.220 <0.001 ≥10万 274 1 043 314 <10万 304 932 316 孕次(次) 11.872 0.001 12.785 <0.001 8.949 0.003 ≥3 421 1 368 452 <3 157 607 178 产次(次) 17.327 <0.001 20.588 <0.001 5.715 0.017 ≥3 241 741 241 <3 337 1 234 389 饮食不佳 0.812 0.367 0.760 0.383 1.005 0.316 是 145 478 139 否 433 1 497 491 饮酒 2.261 0.133 0.643 0.423 0.147 0.701 是 111 327 104 否 467 1 648 526 被动烟草暴露 1.419 0.234 0.395 0.529 0.081 0.776 是 119 379 121 否 459 1 596 509 经前紧张综合征 0.522 0.470 0.733 0.392 1.624 0.203 是 154 514 173 否 424 1 461 457 焦虑 166.895 <0.001 66.329 <0.001 257.596 <0.001 是 154 147 130 否 424 1 828 500 抑郁 118.639 <0.001 191.815 <0.001 326.095 <0.001 是 364 577 308 否 214 1 398 322 压力 51.026 <0.001 486.496 <0.001 190.736 <0.001 是 485 1 331 444 否 93 644 186 表 4 变量名称及赋值情况
Table 4. Variable name and assignment
变量类型 变量名称 赋值方法 因变量 睡眠质量 PSQI≤6分=0,PSQI>7分=1 自变量 X1 年龄 <30岁=0,≥30岁=1 X2 孕前BMI <24=0,≥24=1 X3 居住地 城市=(0, 0),城郊=(0,1),农村=, (1,0) X4 学历 初中及以下=0,高中或中专=1,大专及以上=2 X5 职业 职业=(0, 0, 0),职员=(1,0,0),个体户=(0,1,0),无业=(0,0,1) X6 家庭年收入 ≥10万/年=0,<10万/年=1 X7 孕次 <3次=0,≥3=1 X8 产次 <3次=0,≥3=1 X9 饮食不佳 否=0,是=1 X10 饮酒 否=0,是=1 X11 被动烟草暴露 否=0,是=1 X12 经前紧张综合征 否=0,是=1 X13 焦虑 SAS<49分=0,SAS≥50分=1 X14 抑郁 CES-D<15分=0,CES-D≥16分=1 X15 压力 PSS-10≤9分=0,PSS-10>10分=1 表 5 孕期女性睡眠质量变化固定效应分析结果
Table 5. Fixed effect analysis of sleep quality change in pregnant women
变量 B SE t值 P值 95% CI 焦虑 0.548 0.114 5.242 <0.001 0.334~0.762 抑郁 0.768 0.103 6.128 <0.001 0.423~1.113 压力 0.649 0.204 3.214 0.002 0.389~0.909 年龄 0.646 0.283 2.987 0.023 0.355~0.937 BMI 0.356 0.222 1.667 0.109 0.157~0.556 居住地 城郊 0.686 0.514 1.113 0.183 0.397~0.975 农村 0.482 0.339 1.146 0.156 0.236~0.728 学历 高中或中专 0.427 0.267 1.583 0.110 0.197~0.658 大专及以上 0.699 0.307 3.018 0.023 0.364~1.034 职业 个体户 0.478 0.280 3.034 0.088 0.193~0.763 无业 0.429 0.149 3.360 0.004 0.244~0.614 家庭收入(元/年) <10万 0.452 0.219 3.258 0.039 0.278~0.626 孕次(次) ≥3 0.608 0.301 3.309 0.044 0.415~0.801 产次(次) ≥3 0.606 0.254 3.429 0.017 0.433~0.778 饮食不佳 0.424 0.285 1.607 0.137 0.239~0.610 饮酒 0.564 0.387 1.425 0.145 0.374~0.754 被动烟草暴露 0.634 0.465 1.204 0.173 0.398~0.871 经前紧张综合征 0.680 0.549 1.033 0.216 0.433~0.927 -
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