脑小血管病轻度抑郁与脑内红核铁含量相关性研究

李华; 杨华; 范雪怡; 梁骊; 钱海蓉

doi:10.16766/j.cnki.issn.1674-4152.003110

脑小血管病轻度抑郁与脑内红核铁含量相关性研究

doi: 10.16766/j.cnki.issn.1674-4152.003110

李华¹,
杨华²,
范雪怡³,
梁骊²,
钱海蓉^{1, 2, 3, ,}

1.
解放军总医院第三医学中心神经内科，北京 100089
2.
解放军总医院第六医学中心神经内科，北京 100048
3.
华南理工大学医学院，广东广州 510641

基金项目:

首都卫生发展科研专项首发2020-2-5115

详细信息

通讯作者:
钱海蓉，E-mail：bjqhr@hotmail.com

中图分类号: R743 R749.13
计量
- 文章访问数: 259
- HTML全文浏览量: 111
- PDF下载量: 5
- 被引次数: 0
出版历程
- 收稿日期: 2023-02-15
- 网络出版日期: 2023-09-13

Correlation of mild depression in patients with cerebral small vessel disease and iron content in red nucleus

LI Hua¹,
YANG Hua²,
FAN Xueyi³,
LIANG Li²,
QIAN Hairong^{1, 2, 3
, ,}

1.
Department of Neurology, the Third Medical Center of PLA General Hospital, Beijing 100089, China

摘要

摘要: 目的探究脑小血管病(CSVD)轻度抑郁与红核铁含量之间的关系，评估脑小血管病红核改变对抑郁的预测价值。方法收集2021年5月1日—2022年4月30日就诊于解放军总医院神经内科轻度抑郁CSVD患者41例(试验组)和非抑郁CSVD患者40例(对照组)，采用老年抑郁量表(GDS)评定被试者抑郁水平。所有受试者均进行颅脑磁共振磁敏感加权成像扫描，由2名医师测量2组CSVD患者红核感兴趣区(ROI)SWI信号强度值，分析2组CSVD患者红核含铁量，进而探讨轻度抑郁与红核铁含量的相关性。结果轻度抑郁CSVD组患者左侧红核ROI信号强度值(189.36±27.55)较对照组左侧红核ROI信号强度值(213.32±34.33)明显降低(P=0.001)；轻度抑郁CSVD组患者平均红核ROI信号强度值(193.06±26.33)较对照组患者平均红核ROI信号强度值(211.64±33.53)明显降低(P=0.007)；轻度抑郁CSVD组右侧红核ROI信号强度值较对照组无明显变化；Pearson相关性分析发现平均红核ROI信号强度值、左侧红核ROI信号强度值均与抑郁呈负相关关系。结论脑小血管病轻度抑郁与脑内红核含铁量具有相关性，脑内红核铁含量对脑小血管病轻度抑郁有一定的预测价值。
- 抑郁 /
- 脑小血管病 /
- 磁敏感加权成像 /
- 红核
Abstract: Objective To investigate the relationship between mild depression and iron content in the red nucleus in cerebral small vessel disease (CSVD) patients and evaluated the predictive value of red nucleus in mild depression CSVD patients (control group). Methods Forty-one patients with mildly depressed CSVD (experimental group) and 40 patients with non-depressed CSVD attending the Department of Neurology of the General Hospital of the People ' s Liberation Army (PLA) from May 1, 2021 to April 30, 2022 were collected. The depression levels were assessed by the geriatric depression scale (GDS). All subjects underwent magnetic resonance susceptibility weighted imaging scans, the iron content in red nucleus of CSVD patients were semi-quantitatively analyzed using susceptibility weighted imaging (SWI) signal intensity in the region of interest (ROI). The signal intensity in the ROI of the red nucleus was measured by 2 physicians. The iron contents in the red nucleus of the two groups were analyzed and the correlation between mild depression and iron content in the red nucleus of CSVD patients was explored. Results The signal intensity in the left red nucleus ROI (189.36±27.55 vs. 213.32±34.33) and the average signal intensity in the red nucleus ROI (193.06±26.33 vs. 211.64±33.53) of the mild depression CSVD group were significantly lower than those of the control group (P < 0.05), while the signal intensity of the right red nucleus ROI in the mild depression CSVD group were not different from those of the control group. Correlation analysis showed that the mean signal intensity in the red nucleus ROI was negatively correlated with depression, the left signal strength in the red nucleus ROI was negatively correlated with depression. Conclusion Mild depression in CSVD is significantly associated with iron content in the red nucleus, and the content of iron in the red nucleus has a certain value in predicting mild depression of CSVD.
- Depression /
- Small cerebral vascular disease /
- Susceptibility weighted imaging /
- Red nucleus

HTML全文

表 1 2组CSVD患者一般资料及红核ROI信号强度值比较

Table 1. Comparison of the general data and the ROI signal strength of the red nucleus in 2 groups of CSVD patients

组别	例数	年龄(x±s，岁)	性别[例(%)]		GDS评分(x±s，分)	红核ROI信号强度值(x±s)	左侧红核ROI信号强度值(x±s)	右侧红核ROI信号强度值(x±s)
组别	例数	年龄(x±s，岁)	男性	女性	GDS评分(x±s，分)	红核ROI信号强度值(x±s)	左侧红核ROI信号强度值(x±s)	右侧红核ROI信号强度值(x±s)
试验组	41	66.73±7.43	25(60.9)	16(39.1)	13.47±2.31	193.06±26.33	189.36±27.55	196.75±27.23
对照组	40	65.60±6.48	25(62.5)	15(37.5)	4.95±2.01	211.64±33.53	213.32±34.33	209.95±34.02
统计量		0.730^a	0.020^b		17.845^a	2.777^a	3.469^a	1.930^a
P值		0.468	0.888		＜0.001	0.007	0.001	0.057
注：^a为t值，^b为χ²值。

下载: 导出CSV

表 2 红核ROI信号强度值与抑郁评分的相关性分析

Table 2. Correlation analysis between the signal intensity in the ROI of the red nucleus and depression score

红核灰度值	r值	P值	95% CI
平均	-0.266	0.016	-0.452~-0.053
左侧	-0.331	0.003	-0.507~-0.124
右侧	-0.185	0.099	-0.381~0.032

下载: 导出CSV

参考文献(18)

[1]	YAO S, ZHONG Y, XU Y, et al. Quantitative susceptibility mapping reveals an association between brain iron load and depression severity[J]. Front Hum Neurosci, 2017, 11: 442. doi: 10.3389/fnhum.2017.00442
[2]	GIANPAOLO A B, MARINAQ, SALVATOREB, et al. Red nucleus structure and function: from anatomy to clinical neurosciences[J]. Brain Structure and Function, 2021, 226: 69-91. doi: 10.1007/s00429-020-02171-x
[3]	中国研究型医院学会脑小血管病专业委员会《中国脑小血管病诊治专家共识》编写组. 中国脑小血管病诊治专家共识2021[J]. 中国卒中杂志, 2021, 16(7): 716-726. doi: 10.3969/j.issn.1673-5765.2021.07.013 Chinese Association of Research Hospitals cerebral small vascular disease professional committee. Chinese Consensus on Diagnosis and Therapy of Cerebral Small Vessel Disease 2021[J]. Chinese Journal of Stroke, 2021, 16(7): 716-726. doi: 10.3969/j.issn.1673-5765.2021.07.013
[4]	SHI Y, ZENG Y, WU L, et al. A study of the brain abnormalities of post-stroke depression in frontal lobe lesion[J]. Sci Rep, 2017, 7(1): 13203. DOI: 10.1038/s41598-017-13681-w.
[5]	SUNG Y W, KIYAMA S, CHOI U S. Involvement of the intrinsic functional network of the red nucleus in complex behavioral processing[J]. Cereb Cortex Commun, 2022, 3(3): 37.
[6]	SAIKIRAN P, PRIYANKA. Effectiveness of QSM over R2 in assessment of Parkinson ' s disease: a systematic review[J]. Neurol India, 2020, 68(2): 278-281. doi: 10.4103/0028-3886.284377
[7]	JUSTYNA C, EDYTA D, ANNA Z, et al. Cerebral small vessel disease: a review[J]. Adv Clin Exp Med, 2021, 30(3): 349-356. doi: 10.17219/acem/131216
[8]	FICIARA E, STURA I, GUIOT C, et al. Iron deposition in brain: does aging matter[J]. Int J Mol Sci, 2022, 23(17): 10018. DOI: 10.3390/ijms231710018.
[9]	YASH P S, AMRUTA P, SWATI V, et al. A review on iron chelators as potential therapeutic agents for the treatment of Alzheimer ' s and Parkinson ' s diseases[J]. Mol Divers, 2019, 23(2): 509-526. doi: 10.1007/s11030-018-9878-4
[10]	TARNACKA B, JOPOWICZ A, MASLINSKA M, et al. Copper, Iron, and manganese toxicity in neuropsychiatric conditions[J]. Int J Mol Sci, 2021, 22(15): 7820. DOI: 10.3390/ijms22157820.
[11]	GEORGE S A. Mechanisms and treatment of late-life depression[J]. Transl Psychiatry, 2019, 9(1): 188. doi: 10.1038/s41398-019-0514-6
[12]	JEON B U, YU I K, KIM T K, et al. Susceptibility-weighted imaging as a distinctive imaging technique for providing complementary information for precise diagnosis of neurologic disorder[J]. J Korean Soc Radiol, 2021, 82(1): 99-115. doi: 10.3348/jksr.2020.0054
[13]	ALINA N, THOMALLA G. Post-stroke depression: impact of lesion location and methodological limitations-a topical review[J]. Front Neurol, 2017, 8: 498. doi: 10.3389/fneur.2017.00498
[14]	ILUT S, STAN A, BLESNEG A, et al. Factors that influence the severity of post-stroke depression[J]. J Med Life, 2017, 10(3): 167-171.
[15]	CACCIOLA A, MILARDI D, BASILE G A, et al. The cortico-rubral and cerebello-rubral pathways are topographically organized within the human red nucleus[J]. Sci Rep, 2019, 9(1): 12117. DOI: 10.1038/s41598-019-48164-7.
[16]	ZHANG H Y, SHEN H, GAO M, et al. Cannabinoid CB2 receptors are expressed in glutamate neuronsin the red nucleus and functionally modulate motor behavior in mice[J]. Neuropharmacology, 2021, 189: 108538. DOI: 10.1016/j.neuropharm.2021.108538.
[17]	DUMAN R S, SANACORA G, KRYSTAL J H. Altered connectivity in depression: GABA and glutamate neurotransmitter deficits and reversal by novel treatments[J]. Neuron, 2019, 102(1): 75-90. doi: 10.1016/j.neuron.2019.03.013
[18]	杜远, 王龙, 张许来, 等. 运动对抑郁症症状、认知功能和γ-氨基丁酸影响的对照研究[J]. 中华全科医学, 2019, 17(9): 1547-1550. doi: 10.16766/j.cnki.issn.1674-4152.000994 DU Y, WANG L, ZHANG X L, et al. Control study of exercise' influence on depression's symptom, cognitive function and GABA[J]. Chinese Journal of General Practice, 2019, 17(9): 1547-1550. doi: 10.16766/j.cnki.issn.1674-4152.000994