急性脑梗死患者血清β-肌动蛋白与脑电图定量指标相关性分析

江峰; 金春园; 王波娜; 何松彬

doi:10.16766/j.cnki.issn.1674-4152.003027

急性脑梗死患者血清β-肌动蛋白与脑电图定量指标相关性分析

doi: 10.16766/j.cnki.issn.1674-4152.003027

1.
浙江省舟山医院脑电图室，浙江舟山 316000
2.
浙江省舟山医院神经内科

基金项目:

浙江省医药卫生科技计划项目 2022KY1367

详细信息

通讯作者:
何松彬，E-mail：1998hsb@163.com

中图分类号: R743.3 R741.044
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- 文章访问数: 93
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- PDF下载量: 2
- 被引次数: 0
出版历程
- 收稿日期: 2022-11-12
- 网络出版日期: 2023-08-26

Correlation analysis of serum β-actin and quantitative EEG indicators in patients with acute cerebral infarction

1.
Department of EEG Room, Zhoushan Hospital of Zhejiang Province, Zhoushan, Zhejiang 316000, China

摘要

摘要: 目的探讨急性脑梗死患者血清β-肌动蛋白和脑电图定量指标变化，分析二者的相关性。方法选择2021年6月—2022年6月浙江省舟山医院收治的60例急性脑梗死患者作为研究对象，轻度组24例，中度组24例，重度组12例；另选浙江省舟山医院同期健康体检者50人作为对照组。采用酶联免疫吸附法测定β-肌动蛋白水平；采用脑电图仪监测脑电图，计算DTABR值。结果脑梗死组β-肌动蛋白[(1.83±0.34)μg/L]和DTABR值(7.71±0.43)高于对照组[(0.64±0.12)μg/L和6.24±0.32]，t=23.542、19.991，均P＜0.05。重度组血清β-肌动蛋白[(2.29±0.41)μg/L]和DTABR值(8.54±0.47)高于中度组[(1.79±0.36)μg/L和7.68±0.42]与轻度组[(1.27±0.28)μg/L和6.63±0.34]，均P＜0.05；且中度组β-肌动蛋白水平和DTABR值高于轻度组(均P＜0.05)。经Pearson分析，β-肌动蛋白与DTABR值呈线性正相关关系(r=0.584，P=0.002)。经多因素logistic回归分析，β-肌动蛋白和DTABR值为脑梗死患者病情程度的影响因素。结论急性脑梗死患者β-肌动蛋白和DTABR值明显升高，与病情严重程度密切相关，且血清β-肌动蛋白水平与DTABR值呈正相关关系。
- 急性脑梗死 /
- β-肌动蛋白 /
- 脑电图定量 /
- 相关性
Abstract: Objective To explore the changes of serum β-actin and quantitative indicators EEG of acute cerebral infarction, and analyses its correlation. Methods A total of 60 patients with acute cerebral infarction from June 2021 to June 2022 in Zhoushan Hospital of Zhejiang Province were selected. There were 24 cases in mild group, 24 cases in moderate group and 12 cases in severe group; Another 50 cases of physical examination in the same period in Zhoushan Hospital of Zhejiang Province were selected as the control group. β-actin level measured by enzyme-linked immunosorbent assay. EEG was used to monitor patients ' EEG, and relative power value and power ratio index of each frequency band(DTABR) was calculated. Results The β-actin level [(1.83±0.34)μg/L] and DTABR value (7.71±0.43) in the cerebral infarction group were higher than those in the control group [(0.64±0.12)μg/L and 6.24±0.32], t=23.542, 19.991, both P < 0.05. The β-actin level [(2.29±0.41) μg/L] and DTABR value (8.54±0.47) in the severe group were higher than those in the moderate group [(1.79±0.36)μg/L and 7.68±0.42] and mild group [(1.27±0.28) μg/L and 6.63±0.34], all P < 0.05, while the β-actin level and DTABR value in the moderate group were higher than those in the mild group (all P < 0.05). The Pearson analysis showed that the level of β-actin was positively correlated with the DTABR value (r=0.584, P=0.002). Multivariate logistic regression analysis showed that β-actin and DTABR were the influencing factors for patients with cerebral infarction. Conclusion Serum β-actin level and DTABR value in patients with acute cerebral infarction significantly increase, which are closely related to the severity of the disease, and the level of β-actin is positively correlated with the value of DTABR.
- Acute cerebral infarction /
- β-actin /
- Electroencephalogram quantification /
- Correlation

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表 1 2组研究对象血清β-肌动蛋白水平和DTABR值比较(x ±s)

Table 1. Comparison of serum β-actin levels and DTABR values between the two groups (x ±s)

组别	例数	β-肌动蛋白(μg/L)	DTABR值
脑梗死组	60	1.83±0.34	7.71±0.43
对照组	50	0.64±0.12	6.24±0.32
t值		23.542	19.991
P值		＜0.001	＜0.001

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表 2 不同病情程度脑梗死患者血清β-肌动蛋白水平和DTABR值比较(x ±s)

Table 2. Comparison of serum β-actin levels and DTABR values in patients with different severity of cerebral infarction (x ±s)

病情程度	例数	β-肌动蛋白(μg/L)	DTABR值
重度组	12	2.29±0.41^ab	8.54±0.47^ab
中度组	24	1.79±0.36^a	7.68±0.42^a
轻度组	24	1.27±0.28	6.63±0.34
F值		37.766	98.611
P值		＜0.001	＜0.001
注：与轻度组比较，^aP＜0.05；与中度组比较，^bP＜0.05。

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表 3 急性脑梗死患者β-肌动蛋白水平和DTABR值多因素logistic回归分析

Table 3. Multivariate logistic regression analysis of β-actin level and DTABR value in patients with acute cerebral infarction

变量	B	SE	Waldχ²	P值	OR值	95% CI
β-肌动蛋白	1.672	0.637	6.890	0.009	5.323	1.527~18.551
DTABR值	1.418	0.647	4.803	0.028	4.129	1.162~14.675
注：因变量为急性脑梗死(未发生=0，发生=1)；自变量为β-肌动蛋白(≤1.83 μg/L=0，>1.83 μg/L=1)和DTABR值(≤7.71=0，>7.71=1)。

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