Disease burden and risk factors of pancreatic cancer in China in 1990 and 2019
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摘要:
目的 分析1990年和2019年中国胰腺癌发病、死亡和疾病负担情况。 方法 利用2019年全球疾病负担数据库，分析总人群、不同年龄组间1990年和2019年我国胰腺癌发病、死亡、伤残调整寿命年(DALY)、过早死亡损失寿命年(YLL)和伤残损失寿命年(YLD)，并对胰腺癌进行危险因素归因分析。 结果 2019年中国胰腺癌发病人数为11.49万，发病率为8.08/10万，较1990年分别增长了330.34%和257.52%。2019年死亡人数为11.74万，死亡率为8.25/10万，较1990年分别上升了333.21%和260.26%。2019年中国胰腺癌DALY、YLD和YLL分别为280.52万人年、2.39万人年和278.13万人年，较1990年分别上升了274.33%、319.30%和273.98%。2019年胰腺癌发病率、死亡率和DALY率均随年龄增长而升高，发病率、死亡率和DALY率最高的年龄组均为＞70岁年龄组，分别为44.75/10万、50.09/10万和742.81/10万。中国胰腺癌归因于吸烟导致的死亡人数、DALY和YLL分别为26 552人年、612 359人年和607 033人年。 结论 我国胰腺癌的疾病负担在1990—2019年间有较大增长，应采取积极的预防措施以减轻胰腺癌的疾病负担。 Abstract:Objective To analyse the incidence, mortality and disease burden of pancreatic cancer in China in 1990 and 2019. Methods The global disease burden database in 2019 was used to analyse the incidence, mortality, disability adjusted life years (DALY), premature death loss years (YLL) and disability life years (YLD) of pancreatic cancer in the total population and age groups in 1990 and 2019. Risk factors attributable to pancreatic cancer were also analysed. Results The incidence of pancreatic cancer in China was 114 900 in 2019, and the incidence rate was 8.08/105, representing an increase of 330.34% and 257.52% compared with 1990. In 2019, the number of deaths was 117 400, and the mortality rate was 8.25/105, indicating an increase of 333.21% and 260.26% compared with 1990. In 2019, the DALY, YLD and YLL of pancreatic cancer in China were 2 805 200, 23 900 and 2 781 300, by contrast, form 1990, such values increased by 274.33%, 319.30% and 273.98%, respectively. In 2019, the incidence rate, mortality rate and DALY rate of pancreatic cancer increased with age. The highest incidence rate (44.75/105), mortality rate (50.09/105) and DALY rate (742.81/105) were all observed in the >70 age group. The mortality rate, DALY and YLL attributed to smoking in Chinese patients with pancreatic cancer was 26 552, 612 359 and 607 033, respectively. Conclusion The burden of pancreatic cancer in China has increased considerably from 1990 to 2019. Therefore, positive preventive measures should be taken to reduce the burden of pancreatic cancer. -
Key words:
- Pancreatic cancer /
- Disease burden /
- Smoking /
- Disability adjusted life years
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图 1 1990—2019年中国与部分国家胰腺癌死亡率分析
Figure 1. Pancreatic cancer mortality in China and some countries from 1990 to 2019
图 2 1990—2019年中国与部分国家胰腺癌DALY率分析
Figure 2. DALY rate of pancreatic cancer in China and some countries from 1990 to 2019
表 1 1990年和2019年胰腺癌发病和死亡情况
Table 1. Incidence and death of pancreatic cancer, 1990 and 2019
性别 发病数 发病率 标化发病率 1990年(万人) 2019年(万人) 变化率(%) 1990年(1/10万) 2019年(1/10万) 变化率(%) 1990年(1/10万) 2019年(1/10万) 变化率(%) 男性 1.58 6.96 340.51 2.59 9.61 271.04 3.89 7.43 91.00 女性 1.09 4.53 315.60 1.91 6.50 240.31 2.55 4.36 70.98 合计 2.67 11.49 330.34 2.26 8.08 257.52 3.17 5.78 82.33 性别 死亡数 死亡率 标化死亡率 1990年(万人) 2019年(万人) 变化率(%) 1990年(1/10万) 2019年(1/10万) 变化率(%) 1990年(1/10万) 2019年(1/10万) 变化率(%) 男性 1.59 7.02 341.51 2.60 9.69 272.69 4.12 7.69 86.65 女性 1.12 4.72 321.43 1.96 6.76 244.90 2.70 4.58 69.63 合计 2.71 11.74 333.21 2.29 8.25 260.26 3.34 5.99 79.34 
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表 2 1990年和2019年胰腺癌疾病负担情况
Table 2. Disease burden of pancreatic cancer, 1990 and 2019
性别 DALY DALY率 YLD 1990年(万人年) 2019年(万人年) 变化率(%) 1990年(1/10万) 2019年(1/10万) 变化率(%) 1990年(万人年) 2019年(万人年) 变化率(%) 男性 45.55 176.05 286.50 74.66 242.89 225.33 0.34 1.44 323.53 女性 29.38 104.47 255.58 51.24 149.77 192.29 0.23 0.95 313.04 合计 74.94 280.52 274.33 63.31 197.22 211.51 0.57 2.39 319.30 性别 YLD率 YLL YLL率 1990年(1/10万) 2019年(1/10万) 变化率(%) 1990年(万人年) 2019年(万人年) 变化率(%) 1990年(1/10万) 2019年(1/10万) 变化率(%) 男性 0.56 1.99 255.36 45.21 174.61 286.22 74.10 240.90 225.10 女性 0.41 1.36 231.71 29.15 103.52 255.13 50.83 148.41 191.97 合计 0.48 1.68 250.00 74.37 278.13 273.98 62.83 195.54 211.22
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表 3 1990年和2019年不同年龄组胰腺癌发病、死亡以及负担情况
Table 3. Incidence, death, and burden of pancreatic cancer by age group, 1990 and 2019
年龄(岁) 年份 发病率(1/10万) 死亡率(1/10万) DALY率(1/10万) 男性 女性 合计 男性 女性 合计 男性 女性 合计 15~49 1990年 0.80 0.45 0.63 0.72 0.40 0.56 35.19 19.48 27.60 2019年 2.19 0.83 1.53 1.96 0.73 1.36 91.71 33.82 63.51 变化率(%) 173.75 84.44 142.86 172.22 82.50 142.86 160.61 73.61 130.11 50~69 1990年 11.29 7.72 9.57 10.95 7.51 9.29 325.36 219.70 274.42 2019年 18.89 11.28 15.09 18.15 10.85 14.50 528.30 309.57 418.97 变化率(%) 67.32 46.11 57.68 65.75 44.47 56.08 62.37 40.91 52.67 ＞70 1990年 24.57 17.31 20.44 28.13 20.12 23.57 450.65 311.64 371.62 2019年 54.22 36.81 44.75 59.88 41.88 50.09 907.52 604.70 742.81 变化率(%) 120.68 112.65 118.93 112.87 108.15 112.52 101.38 94.04 99.88
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表 4 1990年和2019年胰腺癌归因于3种危险因素的疾病负担
Table 4. Disease burden of pancreatic cancer attributed to the of three risk factors in 1990 and 2019
项目 死亡数 DALY YLL 1990年(人) 2019年(人) 变化率(%) 1990年(人) 2019年(人) 变化率(%) 1990年(人) 2019年(人) 变化率(%) 吸烟 5 529 26 552 380.23 142 185 612 359 330.68 141 037 607 033 330.41 代谢危险因素 1 952 11 992 514.34 48 675 275 175 465.33 48 274 272 759 465.02 高空腹血糖 1 523 8 045 428.23 36 617 175 495 379.27 36 309 173 904 378.96
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