Incidence and mortality of oropharyngeal cancer in the northern part of Anhui Province, 2015-2020
-
摘要:
目的 分析2015—2020年安徽省皖北地区口咽癌发病与死亡情况。 方法 收集2015—2020年安徽省皖北地区口咽癌新发和死亡病例,计算口咽癌的发病率、死亡率、0~74岁累积率、35~64岁截缩率等指标,以2010年中国标准人口计算中国年龄标准化发病率(ASRIC)和死亡率(ASRMC),以1985年Segi ' s世界标准人口为标准计算世界年龄标准化发病率(ASRIW)和死亡率(ASRMW)。 结果 于2015—2020年安徽省皖北地区共收集新发口咽癌病例1 020例,死亡病例404例,口咽癌发病率为3.67/10万,ASRIC为3.91/10万,ASRIW为3.12/10万,0~74岁累积率为0.37%,截缩发病率(35~64岁)为5.80/10万。2015—2020年安徽省皖北地区口咽癌死亡率为1.46/10万,ASRMC为1.56/10万,ASRMW为1.24/10万,0~74岁累积率为0.15%,截缩死亡率(35~64岁)为2.36/10万。 结论 2015—2020年皖北地区口咽癌的发病率和死亡率呈增长趋势,尤其是男性和农村地区。加强口咽癌早期预防、诊断和治疗措施,应作为皖北地区口咽癌防控的重点。 Abstract:Objective To analyze the incidence and mortality of oropharyngeal cancer in the northern part of Anhui Province from 2015 to 2020. Methods New cases and death cases of oropharyngeal cancer in the northern part of Anhui Province in 2015-2020 were collected. The incidence, mortality, cumulative rates (0-74 years), truncation rate (35 and 64 years) and other indicators of oropharyngeal cancer were calculated. The Chinese population census in 2010 were used for calculating the age-standardized cancer incidence/mortality rates (ASRIC/ASRMC) of China, and Segi ' s world population were used for calculating the age-standardized cancer incidence/mortality rates (ASRIW/ASRMW) of the world. Results The total new oropharyngeal cancer cases were 1 020, and oropharyngeal cancer deaths were 404 in the northern part of Anhui Province in 2015-2020. The crude incidence of oropharyngeal cancer in the northern part of Anhui Province was 3.67/105, the ASRIC and ASRIW were 3.91/105 and 3.12/105 with the cumulative incidence rate (0-74 years) of 0.37%, and the truncation incidence (35-64 years) of 5.80/105. The oropharyngeal cancer mortality in the northern part of Anhui Province in 2015-2020 was 1.46/105, the ASRMC and ASRMW were 1.56/105 and 1.24/105, respectively, and the cumulative mortality rate (0-74 years) was 0.15%, the truncation mortality rate (35-64 years) was 2.36/105. Conclusion The incidence and mortality rate of oropharyngeal cancer in the northern part of Anhui Province increased in the 2015-2020 years, especially in male and rural areas. Strengthening the early prevention, diagnosis and treatment of oropharyngeal cancer should be the focus of prevention and control of oropharyngeal cancer in the northern part of Anhui Province. -
Key words:
- Oropharyngeal cancer /
- Incidence /
- Mortality
-
表 1 2015—2020年皖北地区口咽癌发病率
Table 1. Incidence of oropharyngeal cancer in northern Anhui from 2015 to 2020
区域 性别 新发病例 人口 发病率(1/105) 中标发病率(1/105) 世标发病率(1/105) 0~74岁累积发病率(%) 35~64岁截缩发病率(1/105) 城市 男性 290 6 879 002 4.22 4.09 3.60 0.46 5.81 女性 70 6 754 169 1.04 1.01 0.82 0.09 1.47 合计 360 13 633 171 2.64 2.60 2.21 0.27 3.71 农村 男性 501 7 128 035 7.03 8.31 6.59 0.76 13.67 女性 159 6 999 958 2.27 2.75 2.21 0.23 4.32 合计 660 14 127 993 4.67 5.52 4.36 0.50 8.85 城市+农村 男性 791 14 007 037 5.65 5.98 4.86 0.59 8.98 女性 229 13 754 127 1.66 1.77 1.39 0.15 2.60 合计 1 020 27 761 164 3.67 3.91 3.12 0.37 5.80 表 2 2015—2020年皖北地区口咽癌年龄组发病率
Table 2. Age group incidence of oropharyngeal cancer in northern Anhui from 2015 to 2020
年龄组(年) 城市 农村 城市+农村 合计 男性 女性 合计 男性 女性 合计 男性 女性 0~ 0.00 0.00 0.00 0.07 0.12 0.00 0.05 0.08 0.00 5~ 0.16 0.29 0.00 0.17 0.30 0.00 0.17 0.30 0.00 10~ 0.14 0.00 0.30 0.28 0.16 0.42 0.22 0.10 0.37 15~ 0.09 0.00 0.20 0.24 0.31 0.17 0.17 0.17 0.18 20~ 0.00 0.00 0.00 0.09 0.00 0.16 0.04 0.00 0.08 25~ 0.21 0.21 0.20 1.46 0.86 1.98 0.76 0.49 0.99 30~ 0.96 1.08 0.86 1.86 1.32 2.42 1.32 1.17 1.47 35~ 0.37 0.45 0.29 2.19 1.89 2.48 1.13 1.05 1.21 40~ 0.61 0.68 0.54 1.77 2.76 0.90 1.14 1.60 0.71 45~ 3.30 5.19 1.35 7.39 11.63 3.71 5.05 7.81 2.41 50~ 8.65 15.93 0.85 26.67 41.34 12.72 14.35 23.65 4.76 55~ 6.74 9.04 4.43 10.60 17.45 4.09 8.66 13.16 4.26 60~ 8.62 13.56 3.50 12.79 19.98 5.36 11.03 17.28 4.58 65~ 10.77 18.12 3.75 15.56 23.37 6.61 13.50 21.23 5.31 70~ 14.22 27.22 1.93 18.83 30.64 5.74 16.86 29.24 4.04 75~ 12.45 20.20 5.32 15.90 27.97 5.11 14.54 24.88 5.19 80~ 11.55 20.59 3.18 12.05 21.97 5.42 11.87 21.41 4.68 85~ 1.50 3.85 0.00 7.92 22.16 1.07 5.83 15.47 0.74 合计 2.64 4.22 1.04 4.67 7.03 2.27 3.67 5.65 1.66 表 3 2015—2020安徽皖北地区口咽癌死亡率
Table 3. Mortality rate of oropharyngeal cancer in northern Anhui Province from 2015 to 2020
区域 性别 死亡病例 人口 死亡率(1/105) 中标死亡率(1/105) 世标死亡率(1/105) 0~74岁截缩死亡率(%) 35~64岁截缩死亡率(1/105) 城市 男性 107 6 879 002 1.56 1.51 1.31 0.16 2.27 女性 34 6 754 169 0.50 0.50 0.38 0.05 0.43 合计 141 13 633 171 1.03 1.02 0.85 0.11 1.38 农村 男性 211 7 128 035 2.96 3.66 2.94 0.33 6.24 女性 52 6 999 958 0.74 0.94 0.74 0.08 1.66 合计 263 14 127 993 1.86 2.30 1.82 0.21 3.88 城市+农村 男性 318 14 007 037 2.27 2.43 1.98 0.23 3.79 女性 86 13 754 127 0.63 0.66 0.51 0.06 0.92 合计 404 27 761 164 1.46 1.56 1.24 0.15 2.36 表 4 2015—2020年安徽皖北地区口咽癌年龄组死亡率
Table 4. Age-group mortality of oropharyngeal cancer in northern Anhui Province, 2015-2020
年龄组(年) 城市 农村 城市+农村 合计 男性 女性 合计 男性 女性 合计 男性 女性 0~ 0.00 0.00 0.00 0.00 0.00 0.00 0.00 0.00 0.00 5~ 0.00 0.00 0.00 0.00 0.00 0.00 0.00 0.00 0.00 10~ 0.00 0.00 0.00 0.18 0.33 0.00 0.11 0.20 0.00 15~ 0.00 0.00 0.00 0.16 0.31 0.00 0.09 0.17 0.00 20~ 0.15 0.00 0.31 0.00 0.00 0.00 0.08 0.00 0.16 25~ 0.21 0.00 0.40 0.00 0.00 0.00 0.12 0.00 0.22 30~ 0.00 0.00 0.00 0.53 0.53 0.54 0.21 0.21 0.21 35~ 0.30 0.00 0.59 0.94 1.05 0.83 0.56 0.44 0.69 40~ 0.61 0.54 0.67 0.56 0.86 0.30 0.59 0.68 0.50 45~ 1.16 2.27 0.00 3.53 5.46 1.85 2.17 3.57 0.83 50~ 3.43 6.10 0.57 13.93 22.49 5.78 6.75 11.09 2.29 55~ 2.33 4.13 0.52 2.62 4.83 0.51 2.48 4.47 0.52 60~ 1.91 3.77 0.00 5.56 9.03 1.98 4.03 6.82 1.15 65~ 4.31 5.88 2.81 5.97 9.82 1.55 5.26 8.21 2.12 70~ 6.62 10.21 3.22 7.43 11.31 3.13 7.08 10.86 3.17 75~ 5.07 6.73 3.54 6.90 13.35 1.14 6.18 10.72 2.08 80~ 4.95 6.86 3.18 4.64 6.94 3.10 4.75 6.91 3.12 85~ 2.99 7.70 0.00 2.88 8.86 0.00 2.92 8.44 0.00 合计 1.03 1.56 0.50 1.86 2.96 0.74 1.46 2.27 0.63 -
[1] SIEGEL R L, MILLER K D, JAMAL A. Cancer statistics, 2019[J]. CA Cancer J Clin, 2019, 69(1): 7-34. doi: 10.3322/caac.21551 [2] 李建成, 宋培军, 杨东昆, 等. 游离腓动脉双叶穿支皮瓣在晚期口咽癌术后缺损解剖重建中的临床效果[J]. 南方医科大学学报, 2020, 40(6): 814-821. https://www.cnki.com.cn/Article/CJFDTOTAL-DYJD202006008.htmLI J C, SONG P J, YANG D K, et al. Effect of double-leaf perforator free flap posterolateral calf peroneal artery on reconstruction of oropharyngeal anatomy after ablation of advanced oropharyngeal carcinoma[J]. Journal of Southern Medical University, 2020, 40(6): 814-821. https://www.cnki.com.cn/Article/CJFDTOTAL-DYJD202006008.htm [3] 郭蕴, 孙悦, 李建成, 等. 经口入路口腔-口咽癌切除临床分析[J]. 临床耳鼻咽喉头颈外科杂志, 2021, 35(8): 712-717. https://www.cnki.com.cn/Article/CJFDTOTAL-LCEH202108009.htmGUO Y, SUN Y, LI J C, et al. Clinical analysis of oral and oropharyngeal cancer resection through oral approach[J]. Journal of Clinical Otorhinolaryngology Head And Neck Surgery, 2021, 35(8): 712-717. https://www.cnki.com.cn/Article/CJFDTOTAL-LCEH202108009.htm [4] ZHANG L W, LI J, CONG X, et al. Incidence and mortality trends in oral and oropharyngeal cancers in China, 2005-2013[J]. Cancer Epidemiol, 2018, 57: 120-126. doi: 10.1016/j.canep.2018.10.014 [5] PEREA L M E, ANTUNES J L F, PERES M A. Mortality from oral and oropharyngeal cancer: Age-period-cohort effect, Brazil, 1983-2017[J]. Rev Saude Publica, 2021, 55: 72. doi: 10.11606/s1518-8787.2021055003093 [6] BRAY F, FERLAY J, SOERJOMATARAM I, et al. Global cancer statistics 2018: GLOBOCAN estimates of incidence and mortality worldwide for 36 cancers in 185 countries[J]. CA Cancer J Clin, 2018, 68(6): 394-424. doi: 10.3322/caac.21492 [7] CARLANDER A F, GRONHOJ L C, JENSEN D H, et al. Continuing rise in oropharyngeal cancer in a high HPV prevalence area: A Danish population-based study from 2011 to 2014[J]. Eur J Cancer, 2017, 70: 75-82. doi: 10.1016/j.ejca.2016.10.015 [8] 朱伟政, 陈传俊. 游离股前外侧皮瓣在颌面部组织缺损移植重建中的应用[J]. 中华全科医学, 2022, 20(2): 202-205, 297. doi: 10.16766/j.cnki.issn.1674-4152.002312ZHU W Z, CHEN C J. Free anterolateral thigh flap in maxillofacial tissue defect application in transplantation and reconstruction[J]. Chinese Journal of General Practice, 2022, 20(2): 202-205, 297. doi: 10.16766/j.cnki.issn.1674-4152.002312 [9] 邵侠, 叶鹏程, 方一鸣, 等. 游离前臂皮瓣移植修复治疗口腔颌面部肿瘤切除后缺损47例分析[J]. 中华全科医学, 2017, 15(2): 206-209. doi: 10.16766/j.cnki.issn.1674-4152.2017.02.007SHAO Y, YE P C, FANG Y M, et al. Free forearm flap for oral and maxillofacial defects after tumor resection: an analysis of 47 cases[J]. Chinese Journal of General Practice, 2017, 15(2): 206-209. doi: 10.16766/j.cnki.issn.1674-4152.2017.02.007 [10] SHIELD K D, FERLAY J, JEMAL A, et al. The global incidence of lip, oral cavity, and pharyngeal cancers by subsite in 2012[J]. CA Cancer J Clin, 2017, 67(1): 51-64. [11] LIU J, YANG L Y, ZHANG S W, et al. Incidence, mortality, and temporal patterns of oropharyngeal cancer in China: A population-based study[J]. Cancer Commun, 2019, 38(6): 272-281. [12] FARSI N J, ROUSSEAU M C, SCHLECHT N, et al. Aetiological heterogeneity of head and neck squamous cell carcinomas: The role of human papillomavirus infections, smoking and alcohol[J]. Carcinogenesis, 2017, 38(12): 1188-1195. [13] GORMLEY M, DUDDING T, SANDERSON E, et al. A multivariable Mendelian randomization analysis investigating smoking and alcohol consumption in oral and oropharyngeal cancer[J]. Nat Commun, 2020, 11(1): 6071. [14] TANAKA T I, ALAWI F. Human papillomavirus and oropharyngeal cancer[J]. Dent Clin North Am, 2018, 62(1): 111-120. [15] YOU E L, HENRY M, ZEITOUNI A G. Human papillomavirus-associated oropharyngeal cancer: Review of current evidence and management[J]. Curr Oncol, 2019, 26(2): 119-123. [16] GUO L, YANG F, YIN Y, et al. Prevalence of human papillomavirus Type-16 in head and neck cancer among the Chinese population: A meta-analysis[J]. Front Oncol, 2018, 8: 619. -