老年抑郁症患者血清指标与认知功能的相关性研究

陈寿林; 朱生芝; 于畅; 谢曙光; 郑成应

doi:10.16766/j.cnki.issn.1674-4152.002375

老年抑郁症患者血清指标与认知功能的相关性研究

doi: 10.16766/j.cnki.issn.1674-4152.002375

1.
宁波市康宁医院检验科，浙江宁波 315201
2.
宁波市镇海区庄市街道社区卫生服务中心
3.
宁波市康宁医院精神障碍科二病区
4.
宁波市康宁医院心理测验室
5.
宁波市康宁医院老年病区

基金项目:

浙江省医药卫生科技计划项目 2019RC079

详细信息

通讯作者:
陈寿林，E-mail：749148835@qq.com

中图分类号: R749.16 R446
计量
- 文章访问数: 325
- HTML全文浏览量: 137
- PDF下载量: 5
- 被引次数: 0
出版历程
- 收稿日期: 2021-03-12
- 网络出版日期: 2022-08-13

Correlation between serum indexes and cognitive function in elderly patients with depression

1.
Department of Laboratory Medicine, Ningbo Kangning Hospital, Ningbo, Zhejiang 315201, China

摘要

摘要: 目的探讨老年抑郁症患者血清指标与认知功能的相关性，为临床老年抑郁症诊断提供参考。方法选取2018年6月—2019年6月宁波市康宁医院收治的老年抑郁症患者50例设为抑郁组，另选取50例健康体检者设为对照组。比较2组的认知功能、抑郁程度及血清指标，采用Pearson法分析抑郁组血清指标与认知功能的相关性。结果抑郁组汉密尔顿抑郁量表(HAMD)评分为(25.44±4.68)分，明显高于对照组[(4.52±2.24)分，P < 0.05]，简易智能状态检查表(MMSE)评分为(22.36±2.83)分，明显低于对照组[(27.02±2.35)分，P < 0.05]，抑郁组HAMD评分与MMSE评分呈负相关关系(r=-0.420，P < 0.05)。抑郁组5-羟色胺(5-HT)、多巴胺(DA)、去甲肾上腺素(NE)水平明显低于对照组(均P < 0.05)，与HAMD评分呈负相关关系(r=-0.532、-0.477、-0.494，均P < 0.05)，与MMSE评分呈正相关关系(r=0.525、0.476、0.506，均P < 0.05)。抑郁组同型半胱氨酸(Hcy)、胱抑素-C(Cys-C)、白细胞介素(IL)-1β、IL-18水平明显高于对照组(均P < 0.05)，与HAMD评分呈正相关关系(r=0.444、0.457、0.575、0.540，均P < 0.05)，与MMSE评分呈负相关关系(r=-0.404、-0.372、-0.594、-0.419，均P < 0.05)。结论老年抑郁症患者血清指标水平与其抑郁程度、认知功能密切相关，随患者抑郁程度增加、认知水平下降，5-HT、DA、NE水平逐渐降低，Hcy、Cys-C、IL-1β、IL-18水平逐渐升高。
- 老年 /
- 抑郁症 /
- 神经递质 /
- 炎症指标 /
- 认知功能
Abstract: Objective To explore the correlation between serum index and cognitive function in elderly patients with depression and provide reference for clinical diagnosis of senile depression. Methods From June 2018 to June 2019, 50 elderly patients with depression in Ningbo Kangning Hospital were selected as the depression group, and 50 healthy people were selected as the control group. The cognitive function, depression degree and serum indexes were compared between the two groups. Pearson method was used to analyse the correlation between serum indicators and cognitive function in depression group. Results The Hamilton depression scale (HAMD) score of the depression group was (25.44±4.68) points, which was significantly higher than that of the control group [(4.52±2.24) points, P < 0.05], and the mini-mental state examination (MMSE) score was (22.36±2.83) points, which was significantly lower than that of the control group [(27.02±2.35) points, P < 0.05]. There was a negative correlation between HAMD score and MMSE score in the depression group (r=-0.420, P < 0.05). The levels of 5-hydroxytryptamine (5-HT), dopamine (DA) and norepinephrine (NE) in the depression group were significantly lower than those in the control group (all P < 0.05), were negatively correlated with HAMD score (r=-0.532, -0.477, -0.494, all P < 0.05) and positively correlated with MMSE score (r=0.525, 0.476, 0.506, all P < 0.05). The levels of homocysteine (Hcy), Cystatin-C (Cys-C), interleukin (IL)-1β and IL-18 were significantly higher than those in the control group (all P < 0.05), were positively correlated with HAMD score (r=0.444, 0.457, 0.575, 0.540, all P < 0.05) and negatively correlated with MMSE score (r=-0.404, -0.372, -0.594, -0.419, all P < 0.05). Conclusion The level of serum indexes in elderly patients with depression is closely related to the degree of depression and cognitive function. With the increase of depression degree and the decrease of cognitive level, the levels of 5-HT, DA and NE gradually decrease, whereas the levels of Hcy, Cys-C, IL-1β and IL-18 gradually increase.
- Elderly /
- Depression /
- Neurotransmitters /
- Indicators of inflammation /
- Cognitive function

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表 1 2组研究对象一般资料比较

Table 1. Comparison of general data of two groups of subjects

组别	例数	性别(例)		年龄 (x±s，岁)	受教育程度(例)
组别	例数	男性	女性	年龄 (x±s，岁)	小学以下	中学	中学以上
对照组	50	26	24	68.78±7.02	13	27	10
抑郁组	50	22	28	68.12±6.51	14	29	7
统计量		0.641^a		0.487^b	-0.582^c
P值		0.423		0.627	0.561
注：^a为χ²值，^b为t值，^c为Z值。

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表 2 2组研究对象HAMD、MMSE评分比较(x±s，分)

Table 2. Comparison of HAMD and MMSE scores of two groups of subjects (x±s, score)

组别	例数	HAMD评分	MMSE评分
对照组	50	4.52±2.24	27.02±2.35
抑郁组	50	25.44±4.68	22.36±2.83
t值		-28.511	8.958
P值		< 0.001	< 0.001

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表 3 2组研究对象神经递质含量比较(x±s，ng/L)

Table 3. Comparison of neurotransmitter content between the two groups (x±s, ng/L)

组别	例数	5-HT	DA	NE
对照组	50	274.51±22.34	37.28±3.56	136.74±14.22
抑郁组	50	232.57±23.46	29.25±3.28	102.78±12.16
t值		9.154	11.730	12.834
P值		< 0.001	< 0.001	< 0.001

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表 4 2组研究对象Hcy、Cys-C水平比较(x±s)

Table 4. Comparison of Hcy and Cys-C levels between the two groups (x±s)

组别	例数	Hcy(μmol/L)	Cys-C(mg/L)
对照组	50	8.35±2.71	0.73±0.12
抑郁组	50	21.20±5.54	0.97±0.24
t值		-14.733	-6.325
P值		< 0.001	< 0.001

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表 5 2组研究对象炎症指标水平比较(x±s)

Table 5. Comparison of inflammatory indexes between the two groups (x±s)

组别	例数	IL-1β(ng/L)	IL-18(pg/mL)
对照组	50	29.74±5.93	148.67±30.17
抑郁组	50	48.37±5.80	195.73±49.89
t值		-15.881	-5.708
P值		< 0.001	< 0.001

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表 6 抑郁组相关性分析

Table 6. Correlation analysis of depression group

项目	HAMD评分		MMSE评分
项目	r值	P值	r值	P值
5-HT	-0.532	< 0.001	0.525	< 0.001
DA	-0.477	< 0.001	0.476	< 0.001
NE	-0.494	< 0.001	0.506	< 0.001
Hcy	0.444	< 0.001	-0.404	0.004
Cys-C	0.457	< 0.001	-0.372	0.008
IL-1β	0.575	< 0.001	-0.594	< 0.001
IL-18	0.540	< 0.001	-0.419	0.002

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