Analysis on the current situation and influencing factors of fear of cancer recurrence in patients with colorectal cancer undergoing chemotherapy
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摘要:
目的 了解结直肠癌化疗患者癌症复发恐惧现状及影响因素,为制定干预措施提供理论依据。 方法 采用便利抽样法选取2020年7—12月在温州医科大学附属第一医院化疗的219例结直肠癌患者为研究对象。采用一般资料调查问卷、癌症复发恐惧量表、创伤后成长量表、家庭坚韧力量表进行问卷调查。采用SPSS 23.0统计学软件进行t检验、方差分析、Pearson相关分析和多元线性回归分析。 结果 结直肠癌化疗患者癌症复发恐惧得分为(101.11±18.92)分,创伤后成长得分为(60.70±9.13)分,家庭坚韧力得分为(56.49±7.82)分。不同年龄、学历、家庭人均收入、术后时间、疾病分期、并发症的结直肠癌化疗患者癌症复发恐惧得分差异均有统计学意义(均P < 0.05)。Pearson相关分析结果显示,结直肠癌化疗患者创伤后成长、家庭坚韧力得分均与癌症复发恐惧得分呈负相关(r值分别为-0.325, -0.328),差异有统计学意义(均P < 0.01)。多元线性回归分析结果显示,疾病分期、家庭坚韧力、创伤后成长、学历与患者癌症复发恐惧相关(β值分别为0.380、-0.232、-0.190、-0.216,均P < 0.05)。 结论 结直肠癌化疗患者癌症复发恐惧水平较高,应针对患者的疾病分期、家庭坚韧力、创伤后成长及学历情况采取相应的干预措施,缓解患者的癌症复发恐惧,提高患者的生活质量。 Abstract:Objective To investigate the current situation and influencing factors of fear of cancer recurrence amongst patients with colorectal cancer undergoing chemotherapy and provide theoretical basis for the development of clinical intervention measures. Methods A total of 219 patients with colorectal cancer receiving chemotherapy in our hospital from July to December 2020 were selected as the research objects by convenience sampling. The general data questionnaire, the Fear of Cancer Recurrence Inventory, the Posttraumatic Growth Inventory and the Family Hardiness Index were used for the questionnaire survey. SPSS 23.0 software was used for t test, analysis of variance, Pearson correlation analysis and multiple linear regression analysis. Results The scores of fear of cancer recurrence, posttraumatic growth and family hardiness were (101.11±18.92) points, (60.70±9.13) points and (56.49±7.82) points, respectively, in patients undergoing colorectal cancer chemotherapy. Statistically significant differences in fear of cancer recurrence scores were found amongst patients undergoing chemotherapy for colorectal cancer with different ages, educational background, family per capita income, postoperative time, disease stage and complications (all P < 0.05). Pearson correlation analysis showed that the scores of posttraumatic growth and family hardiness of patients undergoing chemotherapy for colorectal cancer were negatively correlated with the scores of fear of cancer recurrence (r=-0.325 and -0.328, respectively), with statistical significance (all P < 0.01). Multiple linear regression analysis showed that disease stage, family hardiness, posttraumatic growth and level of education were correlated with patients' fear of cancer recurrence (β values were 0.380, -0.232, -0.190, -0.216, respectively), with statistical significance (all P < 0.05). Conclusion The level of fear of cancer recurrence in patients undergoing chemotherapy for colorectal cancer is high, and intervention measures should be in accordance with patients' disease stage, family hardiness, posttraumatic growth and educational background to alleviate the fear of cancer recurrence and improve the quality of life of patients. -
Key words:
- Colorectal cancer /
- Fear of cancer recurrence /
- Posttraumatic growth /
- Family hardiness
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表 1 结直肠癌化疗患者癌症复发恐惧各维度得分及总分(x ±s, 分)
项目 条目数 均分 条目均分 触发因素 8 20.74±4.73 2.59±0.59 功能障碍 6 15.29±2.82 2.55±0.47 严重程度 9 22.53±5.22 2.50±0.58 应对策略 9 20.85±4.96 2.32±0.55 心理痛苦 4 9.18±2.12 2.30±0.53 洞察力 3 6.28±1.73 2.09±0.58 寻求安慰 3 6.24±1.61 2.08±0.54 表 2 不同特征结直肠癌化疗患者癌症复发恐惧得分比较(x ±s,分)
项目 例数 癌症复发恐惧得分 统计量 P值 年龄(岁) 4.124a 0.017 < 50 46 106.70±16.07 50~60 101 101.22±16.61 > 60 72 97.39±18.58 性别 0.465b 0.643 男性 122 101.60±16.09 女性 97 100.49±19.03 学历 4.520b < 0.001 初中及以下 127 105.45±16.18 高中及以上 92 95.12±17.38 婚姻状况 1.039b 0.300 在婚 178 100.52±17.42 未婚、离异或丧偶 41 103.66±17.39 家庭人均收入(元/月) 4.943a 0.008 < 5 000 124 104.00±15.83 5 000~8 000 63 98.98±18.61 > 8 000 32 94.09±18.73 医疗付费方式 0.913b 0.362 医保 193 100.72±17.70 自费 26 104.04±15.19 术后时间(月) 3.883a 0.022 < 3 115 103.55±16.02 3~6 66 100.59±17.88 > 6 38 94.63±19.34 疾病分期 6.954a < 0.001 Ⅰ期 17 95.35±17.68 Ⅱ期 146 99.06±16.12 Ⅲ期 41 104.71±18.78 Ⅳ期 15 117.73±15.83 诊断 0.080b 0.936 结肠癌 33 101.33±19.50 直肠癌 186 101.07±17.08 并发症 2.460b 0.015 有 58 105.88±16.95 无 161 99.39±17.32 注:a为F值,b为t值。 表 3 结直肠癌化疗患者创伤后成长、家庭坚韧力得分与癌症复发恐惧得分的Pearson相关性分析(x ±s,分)
项目 得分 r值 P值 创伤后成长总分 60.70±9.13 -0.325 < 0.001 人生感悟 20.61±3.66 -0.290 < 0.001 个人力量 9.81±1.95 -0.270 < 0.001 新的可能性 10.02±2.80 -0.307 < 0.001 与他人关系 10.57±1.65 -0.251 < 0.001 自我转变 9.69±2.75 -0.271 < 0.001 家庭坚韧力总分 56.49±7.82 -0.328 < 0.001 承担 26.79±3.68 -0.315 < 0.001 挑战 12.77±2.13 -0.320 < 0.001 控制 16.93±2.40 -0.269 < 0.001 表 4 结直肠癌化疗患者癌症复发恐惧影响因素变量赋值
变量 赋值方法 年龄 < 50岁=1,50~60岁=2, > 60岁=3 学历 初中及以下=1,高中及以上=2 家庭人均收入 < 5 000元/月=1;5 000~8 000元/月=2; > 8 000元/月=3 术后时间 < 3个月=1;3~6个月=2; > 6个月=3 疾病分期 Ⅰ期=1;Ⅱ期=2;Ⅲ期=3;Ⅳ期=4 并发症 有=1;无=2 创伤后成长评分 实际值赋值 家庭坚韧力评分 实际值赋值 表 5 结直肠癌化疗患者癌症复发恐惧影响因素的多元线性回归分析
项目 B SE β t值 P值 疾病分期 9.563 1.601 0.380 5.975 < 0.001 家庭坚韧力 -0.588 0.144 -0.232 -4.079 < 0.001 创伤后成长 -0.458 0.139 -0.190 -3.290 0.001 学历 -7.593 3.304 -0.216 -2.298 0.023 -
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