多种健脾消食中成药治疗儿童亚急性湿疹的对比研究

杨明; 顾菲; 朱芸; 刘晓雁; 高莹

doi:10.16766/j.cnki.issn.1674-4152.002190

多种健脾消食中成药治疗儿童亚急性湿疹的对比研究

doi: 10.16766/j.cnki.issn.1674-4152.002190

首都儿科研究所附属儿童医院皮肤科，北京 100020

基金项目:

国家自然科学基金项目 81703106

详细信息

通讯作者:
高莹，E-mail：yangming2007@126.com

中图分类号: R758.23 R286
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- 被引次数: 0
出版历程
- 收稿日期: 2021-03-11
- 网络出版日期: 2022-02-15

Comparative study of several Chinese patent medicines for strengthening spleen and digestion in the treatment of subacute eczema in children

Department of Dermatology, Children's Hospital Capital Institute of Pediatrics, Beijing 100020, China

摘要

摘要: 目的观察比较多种健脾消食中成药治疗儿童亚急性湿疹的临床疗效和安全性。方法回顾分析2018年6月—2019年6月首都儿科研究所附属儿童医院收治的186例儿童亚急性湿疹患儿的病例资料。按不同治疗方案将患儿分为对照组(48例，采用常规西药治疗)和观察组(138例，在常规西药治疗基础上联用健脾消食的中成药)，观察组按给予中成药的不同分为A组(42例)、B组(57例)和C组(39例)，分别给予的中成药为小儿扶脾颗粒、小儿康颗粒和神曲消食口服液。比较4组患儿的临床疗效、复发情况、瘙痒程度、生活质量及不良反应。结果 1个疗程治疗后，观察组A组、B组和C组的治疗总有效率(83.33%、85.96%、79.49%)均高于对照组的58.33%，且B组与对照组间的差异有统计学意义(P < 0.008)；1个疗程治疗后，观察组A组、B组和C组的瘙痒程度评分[(0.64±0.53)分、(0.49±0.37)分、(0.56±0.48)分]和生活质量评分[(5.24±1.93)分、(5.04±1.01)分、(5.59±2.13)分]均明显优于对照组[(1.41±0.72)分和(8.70±2.91)分，均P < 0.05]，但A、B、C 3组间两两比较差异无统计学意义(均P>0.05)。A、B、C 3组患儿3个月的湿疹复发率均明显低于对照组(均P < 0.008)，且B组3个月湿疹复发率(19.30%)明显低于A组(46.34%，P < 0.008)。各组患者在治疗期间仅发生轻微不良反应，且不良反应发生率比较差异无统计学意义(P>0.05)。结论在健脾消食中成药和常规西药联合治疗儿童亚急性湿疹中，小儿康颗粒在提高疗效和降低复发率上更有优势，值得进一步关注。
- 儿童湿疹 /
- 亚急性 /
- 健脾消食中成药
Abstract: Objective To observe and compare the clinical efficacy and safety of several Chinese patent medicines for strengthening spleen and digestion in the treatment of subacute eczema in children. Methods The clinical data of 186 cases of children with subacute eczema treated in the Children' s Hospital Capital Institute of Pediatrics from June 2018 to June 2019 were retrospectively analyzed. The children were divided into control group (48 cases, conventional Western medicine) and observation group (138 cases, combined with Chinese patent medicines for strengthening spleen and digestion on the basis of the treatment of the control group) according to the treatment plan. The observation group was divided into group A (42 cases), group B (57 cases) and group C (39 cases) according to the difference of Chinese patent medicine, and the medicines included Xiaoerfupi Granule, Xiaoerkang Granule and Shenquxiaoshi Oral Liquid. Then, the efficacy, recurrence, pruritus, quality of life and adverse reactions were compared. Results After one course of treatment, the total effective rates of observation groups A, B and C (83.33%, 85.96% and 79.49%, respectively) were higher than that of the control group (58.33%), and the difference between group B and the control group was significant (P < 0.008). After one course of treatment, the pruritus and quality of life scores of observation groups A, B and C [the pruritus score was (0.64±0.53) points, (0.49±0.37) points and (0.56±0.48) points, respectively; CDLQI scores were (5.24±1.93) points, (5.04±1.01) points and (5.59±2.13) points, respectively] were significantly improved compared with the control group [pruritus score and CDLQI score were (1.41±0.72) points and (8.70±2.91) points, respectively, all P < 0.05]. However, no significant difference was observed amongst the three observation groups (all P>0.05). The recurrence rates of eczema at 3 months in the three observation groups were obviously lower than that in the control group (P < 0.008), and this rate at 3 months was significantly lower in group B (19.30%) than in group A (46.34%, P < 0.008). Only minor adverse reactions occurred in each group during treatment, and no significant difference was observed in the incidence of adverse reactions (P>0.05). Conclusion In the treatment of subacute eczema in children with the Chinese patent medicines for strengthening spleen and digestion combined with western medicine for routine treatment, Xiaoerkang Keli have more advantages in improving curative effect and reducing the recurrence rate, and deserve further attention.
- Childhood eczema /
- Subacute /
- Strengthen spleen and digestion Chinese patent medicines

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图 1 儿童亚急性湿疹患儿治疗前后的代表性例图

注：A为治疗前，B为治疗后(治愈)。

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表 1 4组儿童亚急性湿疹患儿一般临床资料比较

组别	例数	性别(例)		年龄 (x±s, 岁)	病程 (x±s, 月)
组别	例数	男	女	年龄 (x±s, 岁)	病程 (x±s, 月)
对照组	48	23	25	7.31±2.21	2.11±1.72
A组	42	20	22	8.12±2.98	2.33±1.57
B组	57	31	26	7.57±2.73	2.63±1.91
C组	39	19	20	7.84±2.45	2.93±2.04
统计量		0.643^a		1.817^b	1.226^b
P值		0.887		0.175	0.378
注：^a为χ²值，^b为F值。

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表 2 4组儿童亚急性湿疹患儿疗效比较

组别	例数	痊愈 [例(%)]	显效 [例(%)]	好转 [例(%)]	无效 [例(%)]	总有效率 (%)
对照组	48	14(29.17)	14(29.17)	16(33.33)	4(8.33)	58.33(28/48)
A组	42	20(47.62)	15(35.71)	6(14.29)	1(2.38)	83.33(35/42)
B组	57	33(57.89)	16(28.07)	8(14.04)	0(0.00)	85.96^b(49/57)
C组	39	19(48.72)	12(30.77)	7(17.95)	1(2.56)	79.49(31/39)
统计量		13.761^a				13.070^c
P值		0.003				0.004
注：^a为Z值，^c为χ²值。4组间两两比较校正检验水准α=0.008。与对照组比较，^bP＜0.008。

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表 3 4组儿童亚急性湿疹患儿瘙痒程度评分和CDLQI评分比较 (x ±s, 分)

组别	例数	瘙痒程度评分		CDLQI评分
组别	例数	治疗前	治疗1个疗程后	治疗前	治疗1个疗程后
对照组	48	2.47±0.65	1.41±0.72^a	12.42±2.46	8.70±2.91^a
A组	42	2.56±1.09	0.64±0.53^ab	11.85±2.78	5.24±1.93^ab
B组	57	2.72±0.84	0.49±0.37^ab	11.67±2.91	5.04±1.01^ab
C组	39	2.36±0.73	0.56±0.48^ab	11.39±2.71	5.59±2.13^ab
F值		2.019	16.695	1.731	13.776
P值		0.143	＜0.001	0.187	＜0.001
注：与治疗前比较，^aP＜0.05；与对照组比较，^bP＜0.05。

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表 4 4组儿童亚急性湿疹患儿复发情况比较 [例(%)]

组别	例数	1个月内复发	3个月内复发
对照组	44	16(36.36)	32(72.73)
A组	41	4(9.76)^a	19(46.34)^ab
B组	57	6(10.53)^a	11(19.30)^a
C组	38	5(13.16)	16(42.11)^a
χ²值		15.144	66.658
P值		0.002	＜0.001
注：4组间两两比较校正检验水准α=0.008。与对照组比较，^aP＜0.008；与B组比较，^bP＜0.008。

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