Abstract: The number of patients with end-stage renal disease(ESRD) continues to increase all over the world, and both developed and developing countries will face the huge economic burden brought by ESRD. Therefore, it is urgent for us to formulate effective prevention strategies to reduce the disease burden according to different economic development and resources. More and more attention has been paid to the role of multi-disciplinary teamwork in pre-dialysis patient education,which has become a key point in ESRD patient management. Patient education is the main bridge between doctors and patients which can improve patients' medical knowledge and the ability of disease self-management. Patients entering ESRD stage inevitably need to choose the method of RRT(Renal Replacement Therapy), while the difference of patients' personal situation, education provider or social support system will influence them to make reasonable choices according to their own needs. Previous studies have shown that rational and standardized pre-dialysis patient education can improve patients' self-management ability and increase their medical-related knowledge, and these efforts will delay disease progression, avoid emergency dialysis and reduce early mortality. If patients choose more peritoneal dialysis as RRT program, it will directly or indirectly save social medical costs. This review aims to discuss the effects and significance of pre-dialysis patient education on the social economy and patient's personal health. We also discuss the factors that influence patient education, and we expect to make full use of the mobile network and community management platform for the patient follow-up and guidance. At the end, we will summarize the experiences of other chronic diseases management, gradually improve the model of patient education which enabling patients to obtain sufficient medical knowledge and participate in medical decisions actively, and will establish a patient-centered medical management model in the future.