Abstract: Objective To provide the basis for formulating scientific research policies and improving the quality of scientific research management through analyzing the development of scientific research in The Second Hospital of Anhui Medical University from 2015 to 2019. Methods The number, source, and funding of longitudinal scientific research projects in each year were descriptively analyzed. This study focused on the subject distribution of national, provincial and ministerial projects, as well as the age, title, degree (education) of the leader of these projects, and to find out problems and propose improvement measures and suggestions from the data analyze. Results The hospital longitudinal projects come from the national, provincial, and municipal levels, accounting for 9.7%, 23.6%, and 66.7%, respectively, and the high-level and high-quality subjects were few. The funding had increased from 2.961 million RMB in 2015 to 5.087 million RMB in 2019. Although it showed a rapid growth trend, there were also large fluctuations among these years. Among national and provincial projects, the provincial key specialty and school level research center departments account for 67.4%. Young and middle-aged doctoral talents and the introduction of talents were the main groups to enhance the scientific and technological strength of the hospital. Conclusion Through data analysis, we find some deficiencies in scientific research work which are mainly in the unbalanced development between disciplines, such as the gap between key disciplines and general disciplines, few high-quality projects and high-quality achievements, lack of scientific research team striving for major projects, lack of long-term and stable clinical research direction and insufficient research funding. It is suggested that we should focus on the construction of disciplines and strengthen the construction of the talent team, improve the ability and level of scientific research with the support of the construction of the scientific and technological platform, innovate the scientific research management mechanism to promote the improvement of the quality of scientific research projects and achievements, implement effective incentive measures to promote the comprehensive capacity of scientific research management, and carry out high-quality scientific research project incubation plan and increase investment in scientific research funds.