Abstract: Objective To investigate the application value of perioperative evidence-based nursing on enhanced recovery after surgery in patients undergoing laparoscopic surgeries for colorectal cancer. Methods Eighty patients undergoing selective radical resection of colorectal cancer under laparoscope were enrolled in this study from January 2017-May 2018 in Bozhou City People's Hospital. All of patients were randomly divided into evidence-based nursing group and control group, 40 patients in each group. Usual care was applied into patients in control group, and usual care combined with evidence-based nursing was applied into patients in evidence-based nursing group. The mental state and surgical incision healing after operation were evaluated in both two groups. The time to get out of bed after operation and postoperative complications as well as the mean hospitalization time were compared in two groups. Results There were no significances of SAS and SDS scores between control group and evidence-based nursing group. The mental state in both two groups were improved after nursing interventions; moreover, the mental state in evidence-based nursing group were superior to these in control group. Compared to control group, postoperative complications including abdominal hemorrhage, abdominal infection, subincision hemorrhage and incision infection were decreased in observation group, but they didn't achieve statistical threshold. Surgical incision healed better in evidence-based nursing group. Additionally, the time to get out of bed after operation and the mean hospitalization time in evidence-based nursing group were significantly shorter than these in control group(t=-10.304,-9.157, all P<0.001). Conclusion Perioperative evidence-based nursing can decrease incidences of abdominal hemorrhage, abdominal infection, subincision hemorrhage and incision infection, and improve surgical incision healing as well as enhanced recovery after surgery.