Abstract: Objective To study the effect of self-management nursing on patients with hepatitis B cirrhosis. Methods Ninety-four patients with hepatitis B cirrhosis were selected from May 2016 to May 2017 in the General Hospital of Shenma Medical Group. They were randomly divided into routine group and research group, 47 cases in each group. The routine group was given routine nursing, while the research group was given self-management nursing. The related indicators of liver function of the two groups were detected. Child-Pugh scores, self-efficacy, self-management, quality of life evaluation before and after nursing were counted, and nursing satisfaction was counted. Results The related indexes of liver function and Child-Pugh score of the two groups after nursing were lower than those before nursing. The scores of self-efficacy, quality of life, self-monitoring, core management ability and disease knowledge of the two groups after nursing were higher than those before nursing, and the difference was statistically significant(all P<0.05). After nursing, the indexes of liver function and Child-Pugh score in the study group were lower than those in the conventional group. The scores of self-efficacy, quality of life, self-monitoring, core management ability and disease knowledge in the study group were higher than those in the conventional group. The difference was statistically significant(all P<0.05). The nursing satisfaction of the study group was 93.62%, which was higher than that of the routine group(78.72%). The difference was statistically significant(P<0.05). Conclusion The self-management nursing practice of patients with hepatitis B cirrhosis has remarkable effect. It can effectively improve the liver function of patients, improve the self-efficacy, self-management ability and quality of life of patients, and the nursing satisfaction is high.