Abstract: Objective To explore the value of comprehensive nursing intervention for patients with lung injury undergoing respiratory therapy. Methods A total of 120 patients with lung injury who received respiratory treatment in our hospital from June 2016 to June 2017 were selected and divided into general nursing group and comprehensive intervention group according to the random number method, 60 cases in each group. The general nursing group were given medication guidance, dietary nursing and other helpful nursing. The comprehensive intervention group were given comprehensive nursing intervention. Psychological status, quality of life, self-care ability and degree of lung injury were evaluated before and after nursing, and hospitalization time, nursing quality and satisfaction of patients' families were compared. Results The scores of Hamilton Depression Scale (HAMD) and Hamilton Anxiety Scale (HAMA) in the comprehensive intervention group were lower than that in the general nursing group (all P<0.05). After nursing, the quality of life in the comprehensive intervention group was better than that in the general nursing group (all P<0.05). The self-care ability of the comprehensive intervention group was better than that of the general nursing group (all P<0.05). The lung injury score of the comprehensive intervention group was lower than that of the general nursing group (P<0.05). The hospitalization time of the comprehensive intervention group was shorter than that of the general nursing group, and the nursing quality was better than that of the general nursing group (all P<0.05). The total satisfaction of family members in comprehensive intervention group was higher than that in general nursing group (P<0.05). Conclusion Intervention with comprehensive nursing can help patients improve their self-care ability and living standard, improve their psychological status, effectively alleviate the severity of lung injury, help patients recover quickly, and make patients and their families more satisfied.