Abstract: Objective To investigate the effects of Qili Qiangxin capsule combined with high-dose atorvastatin on inflammatory response and vascular microcirculation in patients with hypertension and atherosclerosis. Methods A total of 192 patients with hypertension and atherosclerosis admitted to our hospital from January 2015 to December 2018 were randomly divided into two groups, 96 in each group. The control group was treated with atorvastatin, and the combined group was treated with Qili Qiangxin capsule on this basis. After treatment, inflammatory response (hs-CRP, TNF-α, IL-6), blood lipids (TG, TC, HDL-C, LDL-C), blood pressure (SBP, DPB), hemorheology (Nbh, Nbl, Np, Fh), endothelial function (NO, H₂S, ICAM-1) and changes in plaque conditions (IMT value, PV) were compared between the two groups. Results After treatment, the inflammatory response, blood lipids (TG, TC, LDL-C), blood pressure and hemorheology of two groups were significantly decreased (all P<0.05), and the combination group was significantly lower than the control group (all P<0.05). The levels of HDL-C, NO and H₂S in the two groups were significantly increased (all P<0.05), and the combination group was significantly higher than the control group (all P<0.05). The levels of ICAM-1 in the two groups were significantly decreased, and the combination group was significantly lower than the control group (all P<0.05). After treatment, there was no significant change in IMT and PV levels in the control group (all P>0.05), while IMT and PV levels in the combined group were significantly decreased (all P<0.05). The total effective rate in the combined group (88.5%) was significantly higher than that in the control group (70.8%), χ²=9.299, P=0.002. Conclusion Compared with atorvastatin alone, Qili Qiangxin capsule combined with high-dose atorvastatin can more effectively reduce the inflammatory response and regulate the vascular microcirculation in patients with hypertension and atherosclerosis. The therapeutic effect is more significant.