Abstract: Objective To explore the effect of combined early intervention by physicians in children with congenital heart disease. Methods A total of 140 children with congenital heart disease who were treated in Ningbo Women & Children's Hospital from March 2018 to February 2019 were divided into observation group and control group according to random number table method. The children in the control group were given routine health education and early rehabilitation intervention in pediatric care department, while the children in the observation group were given hospital-family combined early intervention on the basis of the control group. The nutritional status, quality of life and the perception of depression and anxiety of children's family members before and after intervention were compared between the two groups. Results Before intervention, there was no significant difference in nutritional status and quality of life between the two groups (all P>0.05); after intervention, the incidence of malnutrition was 2.9% (2/70) in the observation group, which was significantly lower than 11.4% (8/70) in the control group (P<0.05). The level of nutritional status increased in both groups after intervention. The serum zinc and iron levels in the observation group were significantly higher than those in the control group, the difference was statistically significant (all P<0.05). The scores of quality of life in observation group were higher than those of the control group (all P＜0.05). Before the intervention, there was no significant difference in the scores of depression scale (HAMD) and anxiety scale (HAMA) between the two groups (all P>0.05). After the intervention, HAMD scores and HAMA scores were decreased in both groups，the observation group were lower than that in control group (all P<0.05). Conclusion Doctor combined early intervention can effectively improve the nutritional status and quality of life of children with congenital heart disease, and effectively reduce the negative emotions of their families, which is worthy of clinical application.