Abstract: Objective To research the expression level and significance of heparanase (HPA) and vascular endothelial growth factor (VEGF) in the skin lesions of psoriasis vulgaris at progressing stage. Methods The expression of HPA and VEGF in skin specimens of 25 patients with psoriasis vulgaris at progressing stage and 20 cases of normal control were detected by immunohistochemical S-P. Results The expression of HPA was brown-yellow granular and mainly located in cytoplasm. In psoriasis group, HPA was mainly expressed in spinous layer, basal layer and papillary vascular endothelial cells, but negative in healthy control group. The expression of VEGF was brown-yellow granular, mainly in the cytoplasm. In psoriasis group, the expression of VEGF was mainly in the spinous and papillary vascular endothelial cells, and a little in the basal layer. In healthy control group, the expression of VEGF was negative or a little in the basal layer. The positive rates of HPA and VEGF were 0% and 5% in the control group, and 88% and 96% in the psoriasis group. The positive rates of HPA and VEGF expression in psoriasis group were significantly higher than those in the control group (all P<0.05). The expression of HPA and VEGF in psoriatic lesions was positively correlated (r=0.585, P<0.05). Conclusion The expression of HPA and VEGF in skin lesions of psoriasis vulgaris at progressing stage is significantly higher than that in normal skin. The two factors play an important role in the pathogenesis of psoriasis, and can be used as an auxiliary index for pathological diagnosis of psoriasis vulgaris.