Abstract: Objective To observe the analgesic effect and safety of parecoxib sodium injection combined with dezocine injection in the treatment of severe acute pancreatitis. Methods A total of 57 patients with severe acute pancreatitis from January 2017 to December 2018 of Emergency Surgery Department of the First Affiliated Hospital of Bengbu Medical College were selected. There were 31 males and 26 females among them, with an average age of (45.7±3.6) years and an average weight of (50.4±3.5) kg. They were randomly divided into groups A, B and C. Nineteen patients in the group A received parecoxib sodium + dezocine injection, 18 patients in the group B received dezocine injection, 20 patients in the group C received parecoxib sodium. The effects of physiological indicators such as gender, age and weight on the results were analyzed. The pain experience of patients with severe acute pancreatitis was evaluated by visual analogue scale (VAS). The incidence of adverse events in gastrointestinal tract and cardiac and cerebral vessels was observed. The venous blood of patients in group A was collected on day 1, 3 and 7 after admission to determine the effect of medication on blood routine test result and kidney and liver function. Results There was no significant difference in sex, age and body weight among the three groups (all P>0.05); VAS scores at each time node in group A were lower than those in group B and C (all P<0.05) except for 24 hours after medication; the incidence of gastrointestinal adverse reactions in group A was significantly lower than those in group B (all P<0.05), No statistically significant difference between group A and group C (all all P>0.05) and no respiratory and circulatory system depression was found in all the three groups. There was no statistically significant difference in blood routine test result and liver and kidney function at day 1, 3 and 7 in group A (P>0.05). Conclusion The analgesic effect of Parecoxib sodium injection combined with dezocine injection on patients with severe acute pancreatitis was significantly better than that of Parecoxib sodium injection alone and dezocine injection alone. Parecoxib sodium injection combined with diazoxin injection can be used safely and effectively in the analgesia of patients with severe acute pancreatitis.