Abstract: Objective To investigate the sleep quality and its influence factors in patients with myasthenia gravis (MG) during hospitalization and to further provide theoretical basis for effective interventions. Methods A total of 121 MG patients hospitalized in Tangdu Hospital from February 2017 to June 2018 were investigated by Pittsburgh sleep quality index scale (PSQI), self-rating anxiety scale (SAS), self-rating depression scale (SDS), general information questionnaire and sleep influence factors questionnaire. All data was quantified according to GB/T2828 national standard, and SPSS 25.0 was used for variance analysis, t test and logistic regression analysis. Results The score of PSQI were more than 7 points in 93 of the 121 patients, suggesting that 76.8% of patients with myasthenia gravis had sleep problems. The total score of PSQI and scores of 6 items were significantly different from the domestic norm (all P<0.05). The course of disease, clinical classification, SAS score, SDS score and environmental quality were positively correlated with sleep quality (all P<0.05). The factors influencing sleep quality included disease severity, psychosocial, iatrogenic and environmental factors. Conclusion The MG patients generally have poor sleep quality. Besides the improvement of clinical symptoms, we should also pay more attentions to the sleep quality of patients. For the patients with a long course of disease, negative psychological state and severe systemic symptoms, some proactive interventions should be carried out according to relevant influence factors to promote their recovery and return to normal social life as soon as possible.